17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA

17/21 ABCD-USA 联盟：加州大学洛杉矶分校研究项目现场

• 批准号: 10377500
• 负责人: SUSAN Y BOOKHEIMER
• 金额: $ 130.22万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10377500
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adult; Affect; Age; Alcohol consumption; Alcohols; Anxiety; Athletic Injuries; Behavior; Behavioral; Bioinformatics; Biological; Biological Assay; Biology; Brain; Brain imaging; Caffeine; Calendar; Cannabis; Child; Child Health; Childhood; Clinical assessments; Cognition; Cognitive; Communities; Country; Data; Data Analyses; Decision Making; Development; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethics; Event; Feeling suicidal; Female; Funding; Genetic; Health; Impairment; Individual; Informatics; Interview; Life; Link; Logistics; Longitudinal Studies; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Monitor; Neurocognition; Neurocognitive; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Pathway interactions; Persons; Physical activity; Process; Protocols documentation; Psychopathology; Registries; Research; Research Personnel; Research Project Grants; Resource Informatics; Resources; Risk; Role; Sampling; Schools; Science; Secure; Severities; Siblings; Site; Sleep; Social Functioning; Social isolation; Specific qualifier value; Sports; Standardization; Symptoms; Technology; Teenagers; Telephone; Text; Time; Tobacco; Tobacco use; Training; Traumatic Brain Injury; Triplet Multiple Birth; Twin Multiple Birth; United States; Video Games; Youth; adolescent substance use; adverse outcome; cognitive development; cognitive testing; cohort; college; design; emerging adult; emotional factor; experience; follow-up; gene interaction; informatics infrastructure; marijuana use; mobile application; mobile computing; multimodality; neurodevelopment; neuroimaging; novel; participant retention; physical conditioning; recruit; relating to nervous system; research and development; response; retention rate; sleep pattern; social; social media; substance use; temporal measurement; trend; tv watching; vaping; young adult

Abstract Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. The ABCD Research Consortium consists of 21 research sites across the country, a Coordinating Center, and a Data Analysis and Informatics Resource Center. In its first five years, under RFA- DA-15-015, ABCD enrolled a diverse sample of 11,878 9-10 year olds from across the consortium, and will track their biological and behavioral development through adolescence into young adulthood. All participants received a comprehensive baseline assessment, including state-of-the-art brain imaging, neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, and culture and environment. A similar detailed assessment recurs every 2 years. Interim in-person annual interviews and mid-year telephone or mobile app assessments provide refined temporal resolution of developmental changes and life events that occur over time with minimal burden to participating youth and parents. Intensive efforts are made to keep the vast majority of participants involved with the study through adolescence and beyond, and retention rates thus far are very high. Neuroimaging has expanded our understanding of brain development from childhood into adulthood. Using this and other cutting-edge technologies, ABCD can determine how different kinds of youth experiences (such as sports, school involvement, extracurricular activities, videogames, social media, unhealthy sleep patterns, and vaping) interact with each other and with a child’s changing biology to affect brain development and social, behavioral, academic, health, and other outcomes. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental pathways in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences influence brain development; (5) determine and replicate factors that influence mental health from childhood to young adulthood; (6) characterize relationships between mental health and substance use; and (7) specify how use of substances such as cannabis, alcohol, tobacco, and caffeine affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence the risk for adolescent substance use.

摘要