Core B: Non-human primate core
Core B: Non-human primate core
批准号:
10381475
负责人:
Michael R. Farzan
金额:
$60.27万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-04-15 至 2023-02-28
关键词:
Adverse eventAnimalsAntibodiesBiological AssayCapsidCommunicationComplementDNADependovirusDiagnosticDisease remissionEnsureExperimental DesignsGoalsHealthcareHistologyHumanHuman ResourcesImmunologicsImmunologyIndividualInfectionInterventionLaboratoriesLearningMacacaMacaca mulattaMassachusettsMeasuresMediatingMonitorMusPathologistPathologyPersonal SatisfactionPharmaceutical PreparationsPrimatesProceduresResearchRhesusSafetyShapesUniversitiesValidationVeterinariansViralViral Load resultViral load measurementViral reservoirWisconsinWorkadeno-associated viral vectoradverse event monitoringantibody-dependent cell cytotoxicitycohorthistological studiesimprovedinsightneutralizing antibodynonhuman primateprogramspromoterseropositivesimian human immunodeficiency virussuccesstransgene expressionvectorvirology
中文摘要
点击翻译按钮获取中文摘要
英文摘要
PROJECT SUMMARY (Core B – Non-human Primate Core)
The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus
macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal,
and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human
primate studies. An integrated pipeline is critical to the success of this Program because maximum insight
from these studies will require comparisons across projects and individual animal studies. This pipeline
includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from
each of the four projects and the other cores. Core B is managed by two board-certified veterinarians.
Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will
directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies
outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the
Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective
function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
eCD4-mediated control of SIV infection in the brain
-
批准号:10698442
-
项目类别:
-
资助金额:$91.41万
-
财政年份:2023
-
负责人:Michael R. Farzan
-
依托单位:
Safe, CRISPR/Cas-free B cell editing for therapeutic applications
-
批准号:10725412
-
项目类别:
-
资助金额:$22.13万
-
财政年份:2023
-
负责人:Michael R. Farzan
-
依托单位:
Improving mRNA vaccines with extracellular vesicle-associated immunogens
-
批准号:10573644
-
项目类别:
-
资助金额:$8.28万
-
财政年份:2022
-
负责人:Michael R. Farzan
-
依托单位:
Targeting druggable coronavirus proteins
-
批准号:10514326
-
项目类别:
-
资助金额:$578.68万
-
财政年份:2022
-
负责人:Michael R. Farzan
-
依托单位:
Improving mRNA vaccines with extracellular vesicle-associated immunogens
-
批准号:10850617
-
项目类别:
-
资助金额:$18.96万
-
财政年份:2022
-
负责人:Michael R. Farzan
-
依托单位:
Engineering CAR-B cells for an HIV-1 functional cure
-
批准号:10514882
-
项目类别:
-
资助金额:$69.5万
-
财政年份:2022
-
负责人:Michael R. Farzan
-
依托单位:
Engineering CAR-B cells for an HIV-1 functional cure
-
批准号:10844837
-
项目类别:
-
资助金额:$74.11万
-
财政年份:2022
-
负责人:Michael R. Farzan
-
依托单位:
Therapeutic Use of an Enhanced Form of CD4-Ig
-
批准号:9970576
-
项目类别:
-
资助金额:$92.43万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Therapeutic use of an enhanced form of CD4-Ig
-
批准号:10851165
-
项目类别:
-
资助金额:$20.01万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Eliciting tyrosine-sulfated neutralizing antibodies recognizing the Env apex
-
批准号:10013483
-
项目类别:
-
资助金额:$23.13万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Core B: Non-human primate core
-
批准号:10625274
-
项目类别:
-
资助金额:$55.2万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Project 4: A permanent off-switch for AAV
-
批准号:10625294
-
项目类别:
-
资助金额:$35.43万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Core A: Administrative Core
-
批准号:10381474
-
项目类别:
-
资助金额:$56.54万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Therapeutic Use of an Enhanced Form of CD4-Ig
-
批准号:10591713
-
项目类别:
-
资助金额:$27.53万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Therapeutic Use of an Enhanced Form of CD4-Ig
-
批准号:10534766
-
项目类别:
-
资助金额:$72.17万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
An AAV-mediated functional cure and its impact on the reservoir
-
批准号:10625272
-
项目类别:
-
资助金额:$260.96万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Core A: Administrative Core
-
批准号:10625273
-
项目类别:
-
资助金额:$4.7万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
An AAV-mediated functional cure and its impact on the reservoir
-
批准号:10381472
-
项目类别:
-
资助金额:$313.69万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
Project 4: A permanent off-switch for AAV
-
批准号:10381480
-
项目类别:
-
资助金额:$67.16万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
An AAV-mediated functional cure and its impact on the reservoir
-
批准号:9891590
-
项目类别:
-
资助金额:$293.89万
-
财政年份:2020
-
负责人:Michael R. Farzan
-
依托单位:
海外基金