Core A: Administrative Core

项目概要（核心A -行政核心） 该提案的总体目标是：（1）建立稳健、一致和安全的无ART状态 SIV和SIV感染的恒河猴通过持续表达 抗体和抗体样抑制剂，（2）了解猕猴免疫系统的作用， 抗逆转录病毒治疗促进这些功能性治愈，以及（3）确定这些功能性治愈是否可以 也有助于加速潜伏感染细胞库的衰变。行政核心将 提供一切必要的后勤、科学、管理、统计、监管和财政支持， 促进和协调该方案的研究，从而确保这些目标的顺利完成。 行政核心还将设立一个理事委员会， 在非人灵长类动物研究和应用腺相关病毒载体 治疗和预防病毒感染。该管理委员会每季度举行一次会议， 任命科学顾问和NIH计划官员，并两次独立。行政核心 将为这些会议提供便利。该核心还将通过涵盖 涉及多项目合作的所有手稿的出版费用， 建议，并确保本计划中描述的所有研究的统计支持。最后，核心将 负责遵守动物护理和使用、财务和报告要求 与这个项目有关。

PROJECT SUMMARY (Core A – Administrative Core) The general goals of this proposal are: (1) to establish robust, consistent, and safe states of ART-free remission (‘functional cures’) in SHIV- and SIV-infected rhesus macaques through sustained expression of antibodies and antibody-like inhibitors, (2) to understand the role of the macaque immune system and antiretroviral therapy in facilitating these functional cures, and (3) to determine if these functional cures can also help accelerate the decay of the reservoir of latently infected cells. The Administrative Core will provide all the logistic, scientific, managerial, statistical, regulatory and financial support necessary to facilitate and coordinate the studies of this program, thus ensuring the successful completion of these goals. The Administrative Core will also establish and facilitate the activities of a Governing Committee with broad experience in non-human primate studies and in the application of adeno-associated virus (AAV) vectors to the treatment and prevention of viral infection. This Governing Committee will meet quarterly, twice with an appointed Scientific Advisory and NIH Program officials, and twice independently. The Administrative Core will facilitated these meetings. The Core will also promote cross-project collaborations by covering the publication costs of all manuscripts involving multi-project collaborations central to the goals of this proposal, and ensure statistical support for all studies described in this program. Finally the Core will assume responsibility for compliance with animal care and use, financial, and reporting requirements associated with this program.