Core B: Non-human primate core

核心B：非人类灵长类核心

• 批准号: 10625274
• 负责人: Michael R. Farzan
• 金额: $ 55.2万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625274
• 关键词: Adverse event; Animals; Antibodies; Biological Assay; Board Certification; Capsid; Communication; Complement; DNA; Dependovirus; Diagnostic; Disease remission; Ensure; Exclusion; Experimental Designs; Goals; Healthcare; Histology; Human; Human Resources; Immunologics; Immunology; Individual; Infection; Intervention; Laboratories; Learning; Macaca; Macaca mulatta; Massachusetts; Measures; Mediating; Monitor; Mus; Pathologist; Pathology; Personal Satisfaction; Pharmaceutical Preparations; Primates; Procedures; Research; Rhesus; Safety; Shapes; Universities; Validation; Veterinarians; Viral; Viral Load result; Viral load measurement; Viral reservoir; Wisconsin; Work; adeno-associated viral vector; adverse event monitoring; antibody-dependent cell cytotoxicity; cohort; histological studies; improved; insight; neutralizing antibody; nonhuman primate; programs; promoter; seropositive; simian human immunodeficiency virus; success; transgene expression; vector; virology

PROJECT SUMMARY (Core B – Non-human Primate Core) The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal, and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human primate studies. An integrated pipeline is critical to the success of this Program because maximum insight from these studies will require comparisons across projects and individual animal studies. This pipeline includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from each of the four projects and the other cores. Core B is managed by two board-certified veterinarians. Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.

项目总结（核心B -非人灵长类核心） 该项目的总体目标是建立、优化和理解恒河猴的功能性治疗 猕猴因此，非人类灵长类核心（核心B）是本提案的组织中心， 它寻求建立一个一致和统一的程序和分析管道， 灵长类研究一个综合的管道是至关重要的成功，这一计划，因为最大的洞察力 这些研究需要在项目和个体动物研究之间进行比较。这条管道 包括来自威斯康星州国家灵长类动物研究中心（WNPRC）的努力， 四个项目和其他核心的每一个。核心B由两名董事会认证的兽医管理。 萨维里奥“巴迪”卡普亚诺，DVM，在WNPRC，和查尔斯贝利，DVM，在埃姆恩。卡普阿诺医生会 直接管理WNPRC的所有猕猴研究，贝利博士将协调研究管道 在WNPRC之外，监督与WNPRC相关的病毒学、免疫学、病理学和组织学研究。 在Emmune进行。迈克·法尔赞将监督核心的所有活动， 职能，并与Capuano博士合作，以确保所有非人类灵长类动物研究的合规性。