Core B: Non-human primate core

核心B：非人类灵长类核心

• 批准号: 10625274
• 负责人: Michael R. Farzan
• 金额: $ 55.2万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625274
• 关键词: Adverse event; Animals; Antibodies; Biological Assay; Board Certification; Capsid; Communication; Complement; DNA; Dependovirus; Diagnostic; Disease remission; Ensure; Exclusion; Experimental Designs; Goals; Healthcare; Histology; Human; Human Resources; Immunologics; Immunology; Individual; Infection; Intervention; Laboratories; Learning; Macaca; Macaca mulatta; Massachusetts; Measures; Mediating; Monitor; Mus; Pathologist; Pathology; Personal Satisfaction; Pharmaceutical Preparations; Primates; Procedures; Research; Rhesus; Safety; Shapes; Universities; Validation; Veterinarians; Viral; Viral Load result; Viral load measurement; Viral reservoir; Wisconsin; Work; adeno-associated viral vector; adverse event monitoring; antibody-dependent cell cytotoxicity; cohort; histological studies; improved; insight; neutralizing antibody; nonhuman primate; programs; promoter; seropositive; simian human immunodeficiency virus; success; transgene expression; vector; virology

PROJECT SUMMARY (Core B – Non-human Primate Core) The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal, and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human primate studies. An integrated pipeline is critical to the success of this Program because maximum insight from these studies will require comparisons across projects and individual animal studies. This pipeline includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from each of the four projects and the other cores. Core B is managed by two board-certified veterinarians. Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.

项目摘要（核心 B – 非人类灵长类核心） 该项目的总体目标是建立、优化和了解恒河猴的稳健功能性治疗方法 猕猴。因此，非人类灵长类核心（核心 B）是该提案的组织中心， 它寻求为其所有非人类动物建立一致且统一的程序和检测流程 灵长类动物研究。集成管道对于该计划的成功至关重要，因为最大程度的洞察力 这些研究需要对项目和个体动物研究进行比较。这条管道 包括威斯康星州国家灵长类动物研究中心 (WNPRC) 的努力，以及来自 四个项目中的每一个以及其他核心。核心 B 由两名经过委员会认证的兽医管理。 Saverio “Buddy” Capuano，DVM，来自 WNPRC；Charles Bailey，DVM，来自 Emmune。卡普阿诺博士将 直接管理 WNPRC 的所有猕猴研究，贝利博士将协调研究流程 在 WNPRC 之外，监督与该病毒相关的病毒学、免疫学、病理学和组织学研究 核心并在 Emmune 进行。 Mike Farzan 将监督核心的所有活动并确保其有效 职能，并与 Capuano 博士合作，确保所有非人类灵长类动物研究的监管合规性。