Core B: Non-human primate core

项目摘要(核心B--非人类灵长类核心) 该项目的总体目标是建立、优化和了解恒河猴的强大功能疗法。 猕猴。因此，非人类灵长类核心(核心B)是该提案的组织中心， 它寻求为所有非人类建立一个一致和统一的程序和分析流水线 灵长类研究。整合的渠道对该计划的成功至关重要，因为最大限度地洞察 这些研究将需要跨项目和单独的动物研究进行比较。这条管道 包括威斯康星州国家灵长类研究中心(WNPRC)的努力，贡献来自 四个项目中的每一个和其他核心。CORE B由两名经董事会认证的兽医管理。 萨维里奥·卡普亚诺，WNPRC的DVM，和Charles Bailey，DVM，在Emmune。卡普亚诺博士会 直接管理WNPRC的所有猕猴研究，贝利博士将协调研究管道 在世界核子研究中心之外，监督有关的病毒学、免疫学、病理学和组织学研究 核心，并在埃蒙指挥。Mike Farzan将监督核心的所有活动，并确保其有效性 功能，并与卡普亚诺博士合作，确保所有非人类灵长类研究符合法规。

PROJECT SUMMARY (Core B – Non-human Primate Core) The overall goal of this program is to establish, optimize, and understand robust functional cures in rhesus macaques. The Non-human Primate Core (Core B) is therefore at the organizing center of this proposal, and it seeks to establish a consistent and uniform pipeline of procedures and assays for all of its non-human primate studies. An integrated pipeline is critical to the success of this Program because maximum insight from these studies will require comparisons across projects and individual animal studies. This pipeline includes efforts from the Wisconsin National Primate Research Center (WNPRC), with contributions from each of the four projects and the other cores. Core B is managed by two board-certified veterinarians. Saverio “Buddy” Capuano, DVM, at the WNPRC, and Charles Bailey, DVM, at Emmune. Dr. Capuano will directly manage all macaque studies at the WNPRC, and Dr. Bailey will coordinate the pipeline of studies outside the WNPRC and oversee virology, immunology, pathology and histology studies relevant to the Core and conducted at Emmune. Mike Farzan will oversee all of the Core’s activity and ensure its effective function, and work with Dr. Capuano to ensure regulatory compliance for all non-human primate studies.