Mali ICEMR Project 1: The Epidemiology of Malaria Control Strategies

马里 ICEMR 项目 1：疟疾控制策略的流行病学

• 批准号: 10381466
• 负责人: NAFOMON SOGOBA
• 金额: $ 5.6万
• 依托单位: UNIV OF SCIENCES, TECH & TECH OF BAMAKO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-18 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381466
• 关键词: Adult; Africa; Anopheles Genus; Behavior; Cessation of life; Child; Disease; Entomology; Epidemiology; Exhibits; Exposure to; Geographic Distribution; Geography; Goals; Guidelines; Human; Immune response; Incidence; Infant; Infection; Insecticides; Interdisciplinary Study; Intervention; Knowledge; Length; Link; Long-Term Effects; Malaria; Mali; Maternal Exposure; Modeling; Parasites; Pattern; Plasmodium falciparum; Population; Pregnancy; Prevalence; Prevention; Resistance; Risk; Sahara; Site; Sporozoites; Variant; asexual; base; cohort; malaria infection; malaria transmission; offspring; resistance mechanism; tool; transmission process; vector; vector control; vector mosquito

PROJECT 1 SUMMARY Wide deployment of malaria control tools in the past decade, has significantly contribute to substantial reduction of the incidence and deaths related to the disease in Sub-sahara Africa (ref). Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The gap in our knowledge that this project will fill is information on the relationships interaction among current combination of malaria control interventions, entomologic aspects of transmission and the incidence of human infection and disease in different eco-zones across West Africa that span the savanna and sub-Saharan Sahel region. The goal of this project is to understand why different patterns of malaria epidemiology and endemicity are resilient to current control strategies at four sites in Mali. The four field sites exhibit different endemicities, length of seasonality, and different combinations of control interventions and duration of implementation of those interventions. The specific aims are 1] Determine a cohort-based long-term effect of concurrent malaria control interventions on the incidence of uncomplicated and severe malaria in relation with asexual an sexual malaria infections at 4 ecological settings with different combination of malaria control interventions in West Africa; 2] Determine seasonal changes in malaria vector population composition, biting behavior and sporozoite rates in relation with ongoing vector control tools deployed on each ecological setting; 3] Assess the relationships between temporal and spatial variations in vector epidemiological parameters, and P. falciparum infection and disease in human populations. This project links the different aspects of malaria transmission and disease into a unified whole, adding the ability to distinguish the contributions of different malaria control interventions on parasite population and range of immune responses (Project 2, Immunopahtogenesis) and seasonal and geographical distribution of Anopheline mosquitoes vectors (Project 3). Understanding the factors relating entomologic and epidemiological patterns of transmission will provide more definitive guidelines for malaria control efforts in Mali and in West Africa.

项目1总结 在过去十年中，疟疾控制工具的广泛部署做出了重大贡献 大大减少撒哈拉以南地区与该疾病有关的发病率和死亡率 非洲(参考)。然而，该地区继续承载着全球不成比例的高份额 疟疾死亡造成的疟疾负担。此外，发病率仍然很高，但在一些地区保持稳定 在经历了长时间的下降后，其他设置出现反弹，这与 密集部署疟疾防治工具。我们对这个项目认识上的差距 将填补的是关于当前疟疾组合之间的关系互动的信息 控制干预措施、传播的昆虫学方面和人类 西非不同生态区横跨稀树大草原和 撒哈拉以南萨赫勒地区。这个项目的目标是了解为什么不同 疟疾流行病学和地方性的模式对当前的控制战略具有弹性 在马里的四个地点。这四个野外地点表现出不同的地方性，季节性的长度， 以及控制干预措施的不同组合和实施这些措施的持续时间 干预措施。具体目标是1]确定基于队列的长期效果 并发疟疾控制干预措施对未合并和严重疟疾发病率的影响 疟疾与4种生态环境下的无性和有性疟疾感染的关系 西非疟疾控制干预措施的不同组合；2]确定 疟疾媒介种群构成、叮咬行为和 与在每个生态系统部署的持续病媒控制工具有关的子孢子率 环境；3)评估矢量中的时间和空间变化之间的关系 流行病学参数与人类恶性疟原虫感染和疾病 人口。该项目将疟疾传播和疾病的不同方面联系起来。 整合成一个统一的整体，增加了区分不同疟疾的贡献的能力 控制寄生虫种群和免疫反应范围的干预措施(项目2， 免疫光生作用)和按蚊的季节和地理分布 蚊子媒介(项目3)。了解与昆虫学和生物科学有关的因素 传播的流行病学模式将为疟疾提供更明确的指导方针 在马里和西非的控制努力。