Data Management and Biostatistics

数据管理和生物统计学

• 批准号: 9110811
• 负责人: NAFOMON SOGOBA
• 金额: $ 2.99万
• 依托单位: UNIV OF SCIENCES, TECH & TECH OF BAMAKO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110811
• 关键词: Affect; Africa; Area; Biometry; Biostatistics Core; Clinical Data; Clinical Research; Collaborations; Country; Cutaneous Leishmaniasis; Data; Data Analyses; Data Base Management; Data Collection; Data Quality; Data Security; Data Storage and Retrieval; Development; Disease; Disease Vectors; Ensure; Environmental Risk Factor; Funding; Ghana; Goals; Guidelines; Health; Immune response; Individual; Institution; Institutional Review Boards; Knowledge; Laboratories; Leadership; Leishmaniasis; Life; Mali; Monitor; Parasites; Procedures; Process; Protocols documentation; Public Health; Reporting; Research; Research Personnel; Role; Saliva; Salivary Proteins; Site; System; Training; Tropical Medicine; Update; authority; base; co-infection; data management; design; human subject; meetings; neglect; neglected tropical diseases; novel; novel vaccines; pathogen; prevent; quality assurance; transmission process; vaccine development; vector

There is limited knowledge of leishmaniasis in West Africa including the environmental factors affecting this disease, the role of vector saliva in leishmaniasis and the role of other pathogens in the development of this neglected disease. Recent studies in Mali and Ghana enabled us to formulate more comprehensive questions and propose new hypothesis to increase our understanding of the transmission and development of cutaneous leishmaniasis in the field with the objective to identify novel ways to prevent and treat this neglected disease. The major specific aim of this proposal is to: understand the association of immune responses of individuals living in endemic areas to vector salivary proteins in the development of leishmaniasis and importantly, how these immune responses may be modulated by co-infections with filarial worms. Findings of these study will contribute to guide vaccine development based on salivary gland proteins. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration for each institution involved, 2] provide leadership on administrative issues related to health research, and 3] to contribute in the training of individuals (capacity building) to ensure self-sustaining research and networks on neglected tropical diseases with other Tropical Medicine Research Center. More specifically, the administrative core will 1] Track scientific progress and accomplishments for each of the individual projects and cores; 2] Identify and ensure the coordination of related studies at different field sites and laboratories; 3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects; 4] Develop administrative guidelines to define the responsibilities of investigators, and to ensure the responsible management of funds provided for these studies.

对西非利什曼病的了解有限，包括影响该疾病的环境因素、媒介唾液在利什曼病中的作用以及其他病原体在这种被忽视的疾病发展中的作用。最近在马里和加纳的研究使我们能够提出更全面的问题并提出新的假设，以增进我们对皮肤利什曼病在该领域的传播和发展的了解，目的是找到预防和治疗这种被忽视的疾病的新方法。该提案的主要具体目标是：了解生活在流行地区的个体的免疫反应与利什曼病发展过程中载体唾液蛋白的关系，以及重要的是，了解这些免疫反应如何通过丝虫的共同感染进行调节。这些研究的结果将有助于指导基于唾液腺蛋白的疫苗开发。行政核心的长期目标是：1] 为每个相关机构培养研究管理方面的专业知识，2] 在与健康研究相关的行政问题上提供领导，3] 为个人培训（能力建设）做出贡献，以确保自我维持的研究以及与其他热带医学研究中心有关被忽视的热带病的网络。更具体地说，管理核心将 1] 跟踪每个单独项目和核心的科学进展和成就； 2] 确定并确保不同现场和实验室的相关研究的协调； 3] 确保人类受试者研究遵守IRB和其他监管机构的规定； 4] 制定行政指南来明确研究者的职责，并确保对这些研究提供的资金进行负责任的管理。