Data Management and Biostatistics

数据管理和生物统计学

• 批准号: 8304447
• 负责人: NAFOMON SOGOBA
• 金额: $ 2.93万
• 依托单位: UNIV OF SCIENCES, TECH & TECH OF BAMAKO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8304447
• 关键词: Africa; Area; Biometry; Clinical Data; Clinical Research; Collaborations; Confidentiality; Country; Cutaneous Leishmaniasis; Data; Data Analyses; Data Base Management; Data Quality; Data Security; Data Storage and Retrieval; Development; Disease; Disease Vectors; Ensure; Environmental Risk Factor; Funding; Ghana; Goals; Guidelines; Health; Immune response; Individual; Institution; Institutional Review Boards; Instruction; Knowledge; Laboratories; Leadership; Leishmaniasis; Life; Mali; Monitor; Parasites; Procedures; Process; Protocols documentation; Reporting; Research; Research Personnel; Role; Saliva; Salivary Proteins; Site; System; Training; Tropical Disease; Tropical Medicine; authority; base; data management; design; human subject; meetings; neglect; novel; novel vaccines; pathogen; prevent; quality assurance; transmission process; vaccine development; vector

There is limited knowledge of leishmaniasis in West Africa including the environmental factors affecfing this disease, the role of vector saliva in leishmaniasis and the role of other pathogens in the development of this neglected disease. Recent studies in Mali and Ghana enabled us to formulate more comprehensive quesfions and propose new hypothesis to increase our understanding of the transmission and development of cutaneous leishmaniasis in the field with the objective to idenfify novel ways to prevent and treat this neglected disease. The major specific aim of this proposal is to: understand the association of immune responses of individuals living in endemic areas to vector salivary proteins in the development of leishmaniasis and importantly, how these immune responses may be modulated by co-infecfions with filarial worms. Findings of these study will contribute to guide vaccine development based on salivary gland proteins. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration for each institution involved, 2] provide leadership on administrative issues related to health research, and 3] to contribute in the training of individuals (capacity building) to ensure self-sustaining research and networks on neglected tropical diseases with other Tropical Medicine Research Center. More specifically, the administrative core will 1] Track scientific progress and accomplishments for each of the individual projects and cores; 2] Identify and ensure the coordinafion of related studies at different field sites and laboratories; 3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects; 4] Develop administrative guidelines to define the responsibilifies of investigators, and to ensure the responsible management of funds provided for these studies. RELEVANCE (See instructions): This proposal is relevant to publich health at it will contribute to the development of a potenfial new vaccine against cutaneous leishmaniasis, which is endemic in many poor countries.

关于西非利什曼病的知识有限，包括影响利什曼病的环境因素 疾病、媒介唾液在利什曼病中的作用以及其他病原体在利什曼病发展中的作用 被忽视的疾病。最近在马里和加纳进行的研究使我们能够制定更全面的 提出新的假说，以加深我们对其传播和发展的认识 皮肤利什曼病的现场研究，目的是确定预防和治疗这种疾病的新方法 被忽视的疾病。这项建议的主要具体目标是：了解免疫与 流行地区人群对媒介唾液蛋白在疟疾发病中的反应 利什曼病，以及重要的是，这些免疫反应可能如何被丝虫和丝虫病混合感染所调节 虫子。这些研究结果将有助于指导基于唾液腺的疫苗开发 蛋白质。行政核心的长期目标是：1)发展研究方面的专门知识 为每个涉及的机构提供行政管理，2]就与卫生有关的行政问题提供领导 研究，以及3]为培训个人(能力建设)作出贡献，以确保自给自足 与其他热带医学研究中心就被忽视的热带病进行研究并建立网络。更多 具体地说，行政核心将1]跟踪科学进展和成就， 个别项目和核心；2]确定并确保协调不同外地地点的相关研究 和实验室；3]确保符合IRBs和其他管理当局对人类健康研究的要求 主题；4]制定行政准则，界定调查员的责任，并确保 负责任地管理为这些研究提供的资金。 相关性(请参阅说明)： 这项建议与公众健康有关，因为它将有助于潜在新疫苗的开发 预防皮肤利什曼病，这是许多贫穷国家的地方病。