Expanding access to open-source data acquisition software for next-generation silicon probes

扩大对下一代硅探针的开源数据采集软件的访问

• 批准号: 10380130
• 负责人: Joshua H Siegle
• 金额: $ 47.36万
• 依托单位: ALLEN INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380130
• 关键词: Action Potentials; Adoption; Architecture; Area; Brain; Code; Collaborations; Communities; Computer software; Data; Development; Devices; Documentation; Educational workshop; Electrophysiology (science); Ensure; Feedback; Foundations; Funding; Funding Agency; Future; Hair; Head; Human Resources; Institutes; Interview; Laboratories; Learning; Length; Linux; Measures; Mental Health; Mental disorders; Methods; Neurons; Neurosciences; Operating System; Plant Roots; Process; Research; Research Personnel; Resources; Rodent; Scientist; Services; Signal Transduction; Silicon; Site; Source Code; Standardization; Stream; Structure; Surveys; System; Technology; Testing; Time; Trust; Update; Visualization; base; brain cell; cost; data acquisition; data quality; data standards; density; design; experience; experimental study; extracellular; flexibility; improved; millisecond; nanoelectronics; next generation; open data; open source; relating to nervous system; repository; social media; software development; symposium; tool; voltage; volunteer; web site

We plan to provide software support services for Neuropixels probes, a groundbreaking new tool for recording electrical signals from the brain. These probes—which were created by IMEC, a world-renowned nanoelectronics research center, in collaboration with four funding agencies (HHMI, Allen Institute, Gatsby Foundation, and Wellcome Trust)—will become publicly available in July 2018. Each device consists of a single hair-like shank containing nearly 1000 recording sites, each of which can measure voltage changes with sub-millisecond precision. Not only can these probes simultaneously record action potentials from an order of magnitude more neurons than was previously possible, but the entire package is small enough to be mounted on the head of a freely moving rodent. Given the relatively low cost of these reusable probes, they will become a new standard for electrophysiology. In order to use Neuropixels for our own experiments, the Allen Institute made it possible to stream Neuropixels data into an existing open-source software package, Open Ephys. Funding for this proposal would allow us to hire personnel to provide community-wide support for the integration of Open Ephys and Neuropixels. Support functions would include responding to user requests, maintaining the source code, improving the documentation, and simplifying the processing of installing and upgrading the software. This would serve to make Neuropixels accessible to all laboratories, regardless of their prior experience with electrophysiology. In addition, we plan to gather software plugins developed by users, make them more robust, and disseminate them through a centralized repository. Open Ephys already has a global network of volunteer developers, which we plan to leverage to expand the features of this software. Throughout the process, we will engage with the community via interviews, surveys, conferences, and annual workshops. While our main focus will be on providing support services for Neuropixels users, our efforts will also benefit the broader electrophysiology community. The field is currently lacking open standards for data acquisition, analysis, and visualization, leading to a large amount of redundant development efforts across laboratories. Establishing long-term support for a flexible, powerful, and open-source software platform would provide a terrific foundation for future progress. Thanks to Open Ephys’ modular plugin architecture, it will be easy to adapt when the next technological breakthrough occurs.

我们计划为Neuropixels探针提供软件支持服务，这是一种开创性的记录新工具