Resource Core

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• 批准号: 10380052
• 负责人: Alice F Tarantal
• 金额: $ 130.8万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380052
• 关键词: Adult; Animals; Biological Assay; Blood; Blood specimen; California; Callithrix; Caring; Cells; DNA; Data; Dideoxy Chain Termination DNA Sequencing; Emergency Situation; Ensure; Evaluation; Funding; Genes; Genomics; Genotype; Goals; Infrastructure; Macaca mulatta; Methods; Primates; Procedures; Production; Protocols documentation; Quarantine; Readiness; Reporter; Reporter Genes; Research; Research Personnel; Research Project Grants; Resources; Rhesus; Safety; Sampling; Security Measures; Services; Site; Specificity; Specimen; System; Technology; Testing; Time; Transgenes; Translations; adaptive immunity; age group; base; biobank; experience; genome editing; genome sequencing; hazard; human disease; multidisciplinary; nonhuman primate; programs; quality assurance; reproductive; somatic cell gene editing; tool

Resource Core PROJECT SUMMARY / ABSTRACT The overarching goal of the Resource Core is to provide nonhuman primates in the quantity necessary to meet the needs of Somatic Cell Genome Editing (SCGE) awardees. The Resource Core is embedded within the established, comprehensive infrastructure provided by the California National Primate Research Center. Rhesus macaques and marmosets will be available for SCGE investigator studies to be conducted in the Genome Editing Testing Core and in order to generate data on efficiency, specificity, and safety of the technologies developed. The Resource Core will accelerate translation of genome editing technologies from studies in nonhuman primates into treatments for human diseases through the following Specific Aims: (1) Provide nonhuman primates and related capabilities for investigator projects, and (2) Receive, breed, and maintain reporter nonhuman primates. The Resource Core will provide at least 100 animals per year, which will include wild-type and reporter rhesus and marmosets. The Resource Core will ensure investigators have the quality and quantity of nonhuman primates necessary to meet their needs both through the provision of currently available animals (wild-type), and through procurement and expansion of reporter strains that will be provided to the Nonhuman Primate Testing Center from the SCGE Large Animal Production investigators. Paired with a robust Coordination Component and the Genome Editing Testing Core, and within the context of the infrastructure of the UC Davis California National Primate Research Center, the Resource Core will deliver the animals needed to comprehensively assess the promise of new genome editing technologies developed by SCGE awardees.

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