Ultrasound Imaging for Nonhuman Primate Translational Research

描述(由申请人提供)：加州国家灵长类动物研究中心转换超声成像计划是计算成像核心的一个组成部分，为NIH资助的研究人员提供最先进的超声成像各方面的服务和专业知识。这一已建立的项目由一家将超声成像用于非人类灵长类动物的领先者指导，并为研究人员提供了独特的机会，将非侵入性超声相关技术和程序纳入他们的研究，并使用非手术超声引导方法来开发和研究人类健康和疾病的猴子模型。这项提议的目标是升级和更换老化的超声成像系统，该系统很快就会达到无法再提供服务的阶段。这大大破坏了可靠性和成像性能，并将该计划支持的研究置于危险之中。此外，在过去的十年里，新的超声成像技术已经被开发出来，这对于这种非人类灵长类动物的翻译研究保持最新至关重要。替换的超声成像系统将在由P.I.领导的已建立的服务结构内进行维护，以满足这一应用的高度需求 有效地满足NIH支持的研究人员的超声成像需求。该成像系统将安装在安全环境中的专用超声成像套件中，并具备职业健康和安全所需的条件。要求提供资金用于商业成像系统(飞利浦iU22 xMATRIX)，该系统具有对所有年龄段(胎儿到老年人)的非人类灵长类动物进行成像所需的功能，并在设备可靠性和性能方面对该计划至关重要，具有公认的声誉。随着这一必要的替代，加州国家灵长类研究中心超声成像计划将继续支持NIH资助的研究人员在当地、地区和全国范围内的高水平转换超声成像需求。

DESCRIPTION (provided by applicant): The California National Primate Research Center translational ultrasound imaging program, a component of the Computational Imaging Core, provides state-of-the-art services and expertise in all aspects of ultrasound imaging to NIH-funded investigators. This established program is directed by a leader in the use of ultrasound imaging for nonhuman primates, and provides unique opportunities for investigators to incorporate non- invasive ultrasound-related techniques and procedures in their research, and to use non-surgical ultrasound- guided methods to develop and study monkey models of human health and disease. The goal of this proposal is to upgrade and replace an aging ultrasound imaging system that will soon reach the stage where servicing will no longer be available. This substantially undermines the reliability and imaging performance, and places the research supported by this program in jeopardy. In addition, new ultrasound imaging technologies have been developed over the past decade that are essential for this nonhuman primate translational research to remain current. The replacement ultrasound imaging system will be maintained within an established service structure led by the P.I. for this application, which has been highly effective in meeting the ultrasound imaging needs of NIH-supported investigators. This imaging system will be located within a dedicated ultrasound imaging suite in a secure environment, and with the required conditions for occupational health and safety. Funding is requested for a commercial imaging system (Philips iU22 xMATRIX) that has the features necessary for imaging nonhuman primates in all age groups (fetal to aged), and with an established reputation for equipment reliability and performance crucial for the program. With this essential replacement the California National Primate Research Center ultrasound imaging program will continue to support the high level of translational ultrasound imaging needs of NIH-funded investigators locally, regionally, and nationally.