Nonhuman Primate IVIS Spectrum Imaging System

非人类灵长类动物 IVIS 光谱成像系统

• 批准号: 8640351
• 负责人: Alice F Tarantal
• 金额: $ 40.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640351
• 关键词: Back; California; Center for Translational Science Activities; Communicable Diseases; Computer software; Detection; Development; Disease; Ensure; Environment; Fluorescence; Funding; Gene Transfer; Goals; Health; Health system; Human; Image; Imaging Techniques; Longevity; Longitudinal Studies; Manufacturer Name; Measurement; Modeling; Monkeys; Primates; Regenerative Medicine; Research; Research Personnel; Risk; Secure; Services; Signal Transduction; Source; Stem cell transplant; Structure; System; Tissue Engineering; United States National Institutes of Health; charge coupled device camera; data acquisition; gene therapy; in vivo imaging; meetings; nonhuman primate; novel; occupational health/safety; optical imaging; programs; transmission process

DESCRIPTION (provided by applicant): The California National Primate Research Center translational in vivo imaging program, which is a component of the Computational Imaging Core, provides state-of-the-art in vivo imaging services and expertise to NIH- funded investigators nationally. This established program includes unique opportunities for investigators to incorporate noninvasive imaging in their research programs, and to study monkey models of human health and disease. The goal of this proposal is to upgrade and replace an optical imaging system that will no longer be supported or serviced by the manufacturer/supplier placing many NIH studies in progress and planned at risk. The replacement IVIS Spectrum Imaging System will be maintained within this established core service structure, which has been highly effective in meeting the in vivo imaging needs of NIH-supported investigators nationwide. This imaging system will be located within a dedicated imaging suite in a secure environment, and with the required conditions for occupational health and safety for research with nonhuman primates. The IVIS Spectrum Imaging System can be used in both reflectance and transmission modes and includes a highly sensitive back-thinned, back-illuminated CCD camera, a broad band excitation source with filters for fluorescence measurements, selectable filters for multispectral detection, and software to control data acquisition, for spectral unmixin, 3D signal localization and quantification, and image display and analysis. In addition to ongoing longitudinal studies in monkeys focused on gene transfer/gene therapy, stem cell transplantation, regenerative medicine, tissue engineering, infectious diseases, and lifespan health, the system will serve as the platform for further development and application of these novel imaging techniques in monkeys, and span research domains. This replacement system will ensure ongoing and new research opportunities at the California National Primate Research Center can continue to meet the needs of NIH- funded investigators locally, regionally, and nationally that are focused on ways to better understand human health and disease.

描述（由申请人提供）：加州国家灵长类动物研究中心转化体内成像项目是计算成像核心的一个组成部分，为全国NIH资助的研究者提供最先进的体内成像服务和专业知识。这个既定的计划包括独特的机会，研究人员将非侵入性成像在他们的研究计划，并研究人类健康和疾病的猴子模型。本提案的目标是升级和更换制造商/供应商不再支持或维修的光学成像系统，使许多NIH研究处于进行中和计划中的风险中。替换的IVIS光谱成像系统将保留在这个已建立的核心服务结构内，该结构在满足全国NIH支持的研究者的体内成像需求方面非常有效。该成像系统将位于安全环境中的专用成像套件内，并具有非人灵长类动物研究所需的职业健康和安全条件。IVIS光谱成像系统可用于反射和透射模式，包括一个高灵敏度的背照式CCD相机、一个带荧光测量滤光片的宽带激发源、用于多光谱检测的可选滤光片以及控制数据采集的软件，用于光谱解混、3D信号定位和定量以及图像显示和分析。除了正在进行的猴子纵向研究，重点是基因转移/基因治疗，干细胞移植，再生医学，组织工程，传染病和终身健康，该系统将作为进一步开发和应用这些新的成像技术在猴子的平台，并跨越研究领域。这一替代系统将确保加州国家灵长类动物研究中心正在进行的和新的研究机会能够继续满足NIH资助的研究人员在当地、地区和全国范围内的需求，这些研究人员专注于更好地了解人类健康和疾病的方法。