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Resource Core

资源核心

基本信息

批准号：
10599932
负责人：
Alice F Tarantal
金额：
$ 108.98万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599932
关键词：
Acceleration Adult Animals Biological Assay Biological Specimen Banks Blood Blood specimen Breeding California Callithrix Caring Cells DNA Data Dideoxy Chain Termination DNA Sequencing Emergency Situation Ensure Evaluation Funding Genes Genome Genomics Genotype Goals Infrastructure Macaca mulatta Methods Primates Procedures Production Productivity Protocols documentation Quarantine Reporter Reporter Genes Research Research Personnel Research Project Grants Resources Rhesus Safety Sampling Security Measures Services Site Specificity Specimen System Technology Testing Transgenes Translations adaptive immunity age group biobank emergency preparedness experience genome editing genome sequencing hazard high volume manufacturing human disease multidisciplinary nonhuman primate programs quality assurance reproductive somatic cell gene editing tool

项目摘要

Resource Core PROJECT SUMMARY / ABSTRACT The overarching goal of the Resource Core is to provide nonhuman primates in the quantity necessary to meet the needs of Somatic Cell Genome Editing (SCGE) awardees. The Resource Core is embedded within the established, comprehensive infrastructure provided by the California National Primate Research Center. Rhesus macaques and marmosets will be available for SCGE investigator studies to be conducted in the Genome Editing Testing Core and in order to generate data on efficiency, specificity, and safety of the technologies developed. The Resource Core will accelerate translation of genome editing technologies from studies in nonhuman primates into treatments for human diseases through the following Specific Aims: (1) Provide nonhuman primates and related capabilities for investigator projects, and (2) Receive, breed, and maintain reporter nonhuman primates. The Resource Core will provide at least 100 animals per year, which will include wild-type and reporter rhesus and marmosets. The Resource Core will ensure investigators have the quality and quantity of nonhuman primates necessary to meet their needs both through the provision of currently available animals (wild-type), and through procurement and expansion of reporter strains that will be provided to the Nonhuman Primate Testing Center from the SCGE Large Animal Production investigators. Paired with a robust Coordination Component and the Genome Editing Testing Core, and within the context of the infrastructure of the UC Davis California National Primate Research Center, the Resource Core will deliver the animals needed to comprehensively assess the promise of new genome editing technologies developed by SCGE awardees.

资源岩芯项目摘要/摘要资源核心的首要目标是提供必要数量的非人类灵长类动物，满足体细胞基因组编辑（SCGE）获奖者的需求。资源核心嵌入在由加州国家灵长类动物研究中心提供的完善的基础设施。恒河猴和绒猴将可用于将在基因组编辑测试核心，为了生成关于基因组编辑的效率、特异性和安全性的数据，技术开发。资源核心将加速基因组编辑技术的翻译，通过以下特定目的，在非人灵长类动物中开展人类疾病治疗研究：（1）为研究者项目提供非人灵长类动物和相关能力，以及（2）接收，繁殖，维持非人类灵长类的报告基因。资源核心每年将提供至少100只动物，包括野生型和报道基因恒河猴和绒猴。资源核心将确保调查人员拥有质量和数量的非人灵长类动物，以满足他们的需要，通过提供目前可用的动物（野生型），并通过采购和扩大报告菌株，由SCGE大型动物生产研究者提供给非人灵长类动物检测中心。与强大的协调组件和基因组编辑测试核心配对，并在加州大学戴维斯分校加州国家灵长类动物研究中心的基础设施，资源核心将提供动物们需要全面评估新的基因组编辑技术的前景， SCGE获奖者。