Core C: Animal Models Core
Core C: Animal Models Core
批准号:
10379434
负责人:
Hartmut Karl-Heinz Weiler
金额:
$14.81万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-03-15 至 2024-02-29
关键词:
AffectAnimal ModelAnimalsBiologicalBiologyBloodCommunitiesConsultationsCore FacilityCryopreservationEvaluationExperimental DesignsFlowchartsGenerationsGeneticGenomic SegmentGenotypeJointsMethodsModelingMouse StrainsMusPhenotypeProductionRat StrainsRattusReagentResearchResearch InstituteResearch PersonnelTechnical ExpertiseTransgenic MiceTransgenic OrganismsValidationVariantWisconsinclinically relevantgenetic informationin vivoin vivo Modelmedical schoolsmodel designnoveloff-target mutationpreservationprogramsvon Willebrand Disease
中文摘要
项目摘要:核心C
动物模型核心将支持体内转基因小鼠和大鼠模型的生成
对新发现的vwf变异体的分析。核心将在与PPG调查人员协商的情况下发挥作用
开发适当的实验设计和方法来生成这些动物模型、生产和
验证所需的实验试剂,利用联合的现有设施和技术专长
血液研究所(BRI)和威斯康星医学院(MCW)的转基因核心设施
生产所需的动物,并管理将转基因小鼠或大鼠分配给PPG
调查人员和更广泛的研究社区。
英文摘要
PROJECT SUMMARY: CORE C
The Animal Model Core will support the generation of genetically modified mouse and rat models for the in vivo
analysis of newly discovered variants of VWF. The Core will function in consultation with the PPG Investigators
to develop the appropriate experimental design and methods to generate these animal models, produce and
validate the required experimental reagents, utilize the existing facilities and technical expertise of the joint
Transgenic Core Facility of the Blood Research Institute (BRI) and the Medical College of Wisconsin (MCW) to
produce the desired animal, and manage the distribution of the genetically altered mice or rats to PPG
Investigators and the wider research community.
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专著(0)
科研奖励(0)
会议论文
Core B: Glyco-genomics and Bioinformatics
-
批准号:10321578
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项目类别:
-
资助金额:$23.27万
-
财政年份:2021
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Core B: Glyco-genomics and Bioinformatics
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批准号:10545007
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项目类别:
-
资助金额:$25.86万
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财政年份:2021
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Core B: Glyco-genomics and Bioinformatics
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批准号:10088966
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项目类别:
-
资助金额:$27.25万
-
财政年份:2021
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Core C: Animal Models Core
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批准号:10113375
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项目类别:
-
资助金额:$16.54万
-
财政年份:2019
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Core C: Animal Models Core
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批准号:10584532
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项目类别:
-
资助金额:$16.44万
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财政年份:2019
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负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Regulation of Innate Immunity by Coagulation Receptors
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批准号:9279265
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项目类别:
-
资助金额:$41.75万
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财政年份:2016
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Regulation of Innate Immunity by Coagulation Receptors
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批准号:9158877
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项目类别:
-
资助金额:$41.75万
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财政年份:2016
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Protein C pathway function in hematopoiesis
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批准号:9037703
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项目类别:
-
资助金额:$41.75万
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财政年份:2014
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Protein C pathway function in hematopoiesis
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批准号:8669684
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项目类别:
-
资助金额:$41.75万
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财政年份:2014
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Protein C pathway function in hematopoiesis
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批准号:9229562
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项目类别:
-
资助金额:$41.75万
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财政年份:2014
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Mechanism of Activated Protein C Action in Sepsis Therapy
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批准号:7883310
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项目类别:
-
资助金额:$40.61万
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财政年份:2008
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Activated Protein C for Treatment of Radiation Combined Injury
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批准号:7651281
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项目类别:
-
资助金额:$16.71万
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财政年份:2008
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Activated Protein C for Treatment of Radiation Combined Injury
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批准号:7559919
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项目类别:
-
资助金额:$27.9万
-
财政年份:2008
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Mechanism of Activated Protein C Action in Sepsis Therapy
-
批准号:7689753
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项目类别:
-
资助金额:$40.29万
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财政年份:2008
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负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Activated Protein C for Treatment of Radiation Combined Injury
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批准号:8142112
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项目类别:
-
资助金额:$41.44万
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财政年份:2008
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Activated Protein C for Treatment of Radiation Combined Injury
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批准号:8311572
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项目类别:
-
资助金额:$40.61万
-
财政年份:2008
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Mechanism of Activated Protein C Action in Sepsis Therapy
-
批准号:8105326
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项目类别:
-
资助金额:$40.61万
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财政年份:2008
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负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
Activated Protein C for Treatment of Radiation Combined Injury
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批准号:8138839
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项目类别:
-
资助金额:$41.82万
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财政年份:2008
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Transgenic/Knockout Core
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批准号:7140698
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项目类别:
-
资助金额:$2.31万
-
财政年份:2005
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负责人:Hartmut Karl-Heinz Weiler
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依托单位:
Analysis of Ian 5 Function
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批准号:6990076
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项目类别:
-
资助金额:$8.87万
-
财政年份:2005
-
负责人:Hartmut Karl-Heinz Weiler
-
依托单位:
海外基金