Mentoring in Patient-Oriented Addiction Research

以患者为导向的成瘾研究的指导

• 批准号: 10380137
• 负责人: JOHN F. KELLY
• 金额: $ 18.96万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380137
• 关键词: Address; Adolescent; Adolescent and Young Adult; Alcoholics Anonymous; Alcohols; Applications Grants; Area; Award; Behavioral; Behavioral Mechanisms; Brain; Clinical; Clinical Research; Clinical Sciences; Cognitive; Communities; Data Collection; Data Set; Development; Development Plans; Discrimination; Disease; Disease remission; Ego; Environmental Risk Factor; Ethics; Evaluation; Fellowship; Fostering; Funding; General Hospitals; Goals; Grant; Group Meetings; Health Services Accessibility; Impulsivity; Individual; International; Intervention; Investigation; K-Series Research Career Programs; Learning; Massachusetts; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Neurosciences; Paper; Pathway Analysis; Pathway interactions; Patients; Peer Review; Pharmacotherapy; Phase III Clinical Trials; Policies; Premature Mortality; Productivity; Program Development; Psychiatry; Public Health; Publications; Recovery; Recovery Support; Relapse; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Role; Running; Science; Scientific Inquiry; Secure; Series; Services; Social Network; Statistical Data Interpretation; Terminology; Testing; Time; Training; United States National Institutes of Health; Work; Writing; addiction; alcohol and other drug; alcohol research; alcohol use disorder; behavior change; biopsychosocial; burden of illness; career; career development; comorbidity; design; disability; improved; medical schools; mid-career faculty; next generation; novel; patient oriented; patient oriented research; patient population; peer; programs; psychologic; psychosocial; research study; responsible research conduct; role model; skills; social factors; social influence; social neuroscience; social stigma; symposium; treatment research

The primary goals of this K24 competitive renewal application are to enable Dr. John Kelly to: 1) conduct career development activities to enhance and extend his patient-oriented addiction research (POAR); and, 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will give Dr. Kelly protected time to devote to career development to increase the impact of his clinical alcohol and other drug (AOD) research and to intensive mentoring of junior clinical researchers, that would otherwise be spent on clinical and administrative duties. Dr. Kelly, Associate Professor of Psychiatry at Harvard Medical School, Director of the Massachusetts General Hospital (MGH) Recovery Research Institute, Program Director of the MGH Addiction Recovery Management Service, and Associate Director of the MGH Center for Addiction Medicine, has conducted POAR since 2001, with studies that identify and investigate successful pathways to recovery from AOD disorders, the impact of addiction terminology on stigma and treatment access, and the mechanisms of behavior change of AOD treatment and recovery support services. Dr. Kelly has accomplished the major goals of his initial K24 award. He has mentored more than 35 junior investigators, many of whom have secured F and K awards, and authored 79 publications, including 27 with a mentee as first author. He has conducted a series of studies that are informing how we treat adolescents and young adults with AOD disorders, and the clinical and public health utility of peer recovery support services to enhance long-term remission. He has expanded his policy work on addiction terminology to inform national debates to reframe how AOD disorders are addressed and decrease stigma and discrimination. Dr. Kelly's research plan for this renewal application includes continued work as a PI on NIH-funded treatment research and to serve as co-investigator on studies with mentees as PI. Furthermore, he plans to work on submitted proposals to: 1) identify the biopsychosocial markers of long-term relapse to AUD following initial remission; 2) conduct a Phase III clinical trial expand testing of a novel integrated psychosocial intervention for adolescent AOD disorders; and, 3) investigate socially-influenced brain changes in recovery from AUD. Dr. Kelly's mentoring plan includes training his mentees in: 1) clinical aspects of AOD disorders; 2) designing and implementing AOD disorder research studies; 3) preparing scientific papers and presentations; 4) writing grant applications; and, 5) the responsible conduct of research. He will accomplish this through a combination of individual and group meetings, collaborative mentoring, role modeling, and integration with the MGH Division of Clinical Research and Office of Career Development. Dr. Kelly's career development plan involves increasing his expertise in social neuroscience, focusing specifically on the role of social and environmental factors in the neuroscience of behavior change and AOD disorder recovery. These activities will enhance both Dr. Kelly's research and mentoring capacity. The public health significance of this application is related to the need to identify biopsychosocial models of alcohol use disorder remission and recovery, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.

这项K24竞争性更新应用的主要目标是使John Kelly博士到达：1）。 开发活动以增强和扩展其注重患者的成瘾研究（POAR）； 2）提供密集型 以及POAR早期研究人员的高质量指导。 K24更新将使凯利博士受到保护的时间 致力于职业发展，以增加其临床酒精和其他药物（AOD）研究的影响，并进行密集 指导初级临床研究人员，否则这些研究人员将用于临床和行政职责。凯利博士， 哈佛医学院精神病学副教授，马萨诸塞州综合医院主任（MGH） 恢复研究所，MGH成瘾恢复管理服务计划主任和助理 MGH成瘾医学中心主任自2001年以来一直在POAR进行，并确定和 调查从AOD疾病中恢复的成功途径，成瘾术语对污名和 治疗访问以及AOD治疗和恢复支持服务的行为改变机制。凯利博士有 实现了他最初的K24奖的主要目标。他指导了35多名初级调查员，其中许多 已经获得了F和K奖，并撰写了79个出版物，其中包括27名受训者作为第一作者。他进行了 一系列研究，这些研究告知我们如何对待青少年和患有AOD疾病的年轻人，以及临床和 同行恢复支持服务的公共卫生公用事业以增强长期缓解。他扩大了政策工作 关于成瘾术语，以告知全国辩论，以重新构架AOD障碍如何解决并降低污名 和歧视。凯利博士的此续签申请的研究计划包括继续作为NIH资助的PI的工作 治疗研究并作为与PI的受训者研究的共同评估者。此外，他计划从事 提交的提案：1）确定初始缓解后的长期复发的生物心理社会标记； 2）进行III期临床试验扩展了针对青少年AOD的新型综合社会心理干预的测试 疾病； 3）研究AUD恢复的社会影响的大脑变化。 凯利博士的指导计划包括培训他的受训者：1）AOD疾病的临床方面； 2）设计和 实施AOD疾病研究； 3）准备科学论文和演讲； 4）写作赠款 申请； 5）负责任的研究行为。他将通过个人和 小组会议，协作指导，角色建模以及与MGH临床研究部和 职业发展办公室。凯利博士的职业发展计划涉及提高他在社会方面的专业知识 神经科学专门关注社会和环境因素在行为改变神经科学中的作用 和AOD疾病恢复。这些活动将增强凯利博士的研究和指导能力。 该应用的公共卫生意义与识别酒精的生物心理社会模型有关 使用障碍的缓解和恢复，以及培训下一代调查人员以发展他们的技能的需求 需要在该患者人群中有效地进行POAR。