Mentoring in Patient-Oriented Addiction Research

以患者为导向的成瘾研究的指导

• 批准号: 10380137
• 负责人: JOHN F. KELLY
• 金额: $ 18.96万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380137
• 关键词: Address; Adolescent; Adolescent and Young Adult; Alcoholics Anonymous; Alcohols; Applications Grants; Area; Award; Behavioral; Behavioral Mechanisms; Brain; Clinical; Clinical Research; Clinical Sciences; Cognitive; Communities; Data Collection; Data Set; Development; Development Plans; Discrimination; Disease; Disease remission; Ego; Environmental Risk Factor; Ethics; Evaluation; Fellowship; Fostering; Funding; General Hospitals; Goals; Grant; Group Meetings; Health Services Accessibility; Impulsivity; Individual; International; Intervention; Investigation; K-Series Research Career Programs; Learning; Massachusetts; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Neurosciences; Paper; Pathway Analysis; Pathway interactions; Patients; Peer Review; Pharmacotherapy; Phase III Clinical Trials; Policies; Premature Mortality; Productivity; Program Development; Psychiatry; Public Health; Publications; Recovery; Recovery Support; Relapse; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Role; Running; Science; Scientific Inquiry; Secure; Series; Services; Social Network; Statistical Data Interpretation; Terminology; Testing; Time; Training; United States National Institutes of Health; Work; Writing; addiction; alcohol and other drug; alcohol research; alcohol use disorder; behavior change; biopsychosocial; burden of illness; career; career development; comorbidity; design; disability; improved; medical schools; mid-career faculty; next generation; novel; patient oriented; patient oriented research; patient population; peer; programs; psychologic; psychosocial; research study; responsible research conduct; role model; skills; social factors; social influence; social neuroscience; social stigma; symposium; treatment research

The primary goals of this K24 competitive renewal application are to enable Dr. John Kelly to: 1) conduct career development activities to enhance and extend his patient-oriented addiction research (POAR); and, 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will give Dr. Kelly protected time to devote to career development to increase the impact of his clinical alcohol and other drug (AOD) research and to intensive mentoring of junior clinical researchers, that would otherwise be spent on clinical and administrative duties. Dr. Kelly, Associate Professor of Psychiatry at Harvard Medical School, Director of the Massachusetts General Hospital (MGH) Recovery Research Institute, Program Director of the MGH Addiction Recovery Management Service, and Associate Director of the MGH Center for Addiction Medicine, has conducted POAR since 2001, with studies that identify and investigate successful pathways to recovery from AOD disorders, the impact of addiction terminology on stigma and treatment access, and the mechanisms of behavior change of AOD treatment and recovery support services. Dr. Kelly has accomplished the major goals of his initial K24 award. He has mentored more than 35 junior investigators, many of whom have secured F and K awards, and authored 79 publications, including 27 with a mentee as first author. He has conducted a series of studies that are informing how we treat adolescents and young adults with AOD disorders, and the clinical and public health utility of peer recovery support services to enhance long-term remission. He has expanded his policy work on addiction terminology to inform national debates to reframe how AOD disorders are addressed and decrease stigma and discrimination. Dr. Kelly's research plan for this renewal application includes continued work as a PI on NIH-funded treatment research and to serve as co-investigator on studies with mentees as PI. Furthermore, he plans to work on submitted proposals to: 1) identify the biopsychosocial markers of long-term relapse to AUD following initial remission; 2) conduct a Phase III clinical trial expand testing of a novel integrated psychosocial intervention for adolescent AOD disorders; and, 3) investigate socially-influenced brain changes in recovery from AUD. Dr. Kelly's mentoring plan includes training his mentees in: 1) clinical aspects of AOD disorders; 2) designing and implementing AOD disorder research studies; 3) preparing scientific papers and presentations; 4) writing grant applications; and, 5) the responsible conduct of research. He will accomplish this through a combination of individual and group meetings, collaborative mentoring, role modeling, and integration with the MGH Division of Clinical Research and Office of Career Development. Dr. Kelly's career development plan involves increasing his expertise in social neuroscience, focusing specifically on the role of social and environmental factors in the neuroscience of behavior change and AOD disorder recovery. These activities will enhance both Dr. Kelly's research and mentoring capacity. The public health significance of this application is related to the need to identify biopsychosocial models of alcohol use disorder remission and recovery, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.

此 K24 竞争性更新申请的主要目标是使 John Kelly 博士能够：1) 开展职业生涯 开展活动以加强和扩展他的以患者为导向的成瘾研究（POAR）； 2) 提供强化 以及为 POAR 的早期职业研究人员提供高质量的指导。 K24 更新将为凯利博士提供受保护的时间 致力于职业发展，以提高其临床酒精和其他药物 (AOD) 研究的影响力，并加强 指导初级临床研究人员，否则这些资金将用于临床和行政职责。凯利博士， 哈佛医学院精神病学副教授、麻省总医院 (MGH) 院长 康复研究所，麻省总医院成瘾康复管理服务项目主任，助理 MGH 成瘾医学中心主任，自 2001 年以来一直进行 POAR，研究发现和 调查从 AOD 疾病中恢复的成功途径、成瘾术语对耻辱的影响以及 治疗的获取，以及 AOD 治疗和康复支持服务的行为改变机制。凯利博士有 完成了他最初获得 K24 奖项的主要目标。他指导过超过 35 名初级研究员，其中许多人 曾获得 F 和 K 奖，并撰写了 79 篇出版物，其中 27 篇以受训者为第一作者。他曾进行过 一系列研究告诉我们如何治疗患有 AOD 疾病的青少年和年轻人，以及临床和 同伴康复支持服务的公共卫生效用，以加强长期缓解。他扩大了政策工作范围 关于成瘾术语，为全国性辩论提供信息，以重新构建 AOD 障碍的解决方式并减少耻辱 和歧视。 Kelly 博士对此续订申请的研究计划包括继续作为 NIH 资助的 PI 开展工作 治疗研究并作为联合研究者与受训者作为 PI 进行研究。此外，他还计划致力于 提交提案以：1）确定初次缓解后 AUD 长期复发的生物心理社会标志物； 2) 开展 III 期临床试验，扩大测试针对青少年 AOD 的新型综合心理社会干预措施 疾病； 3) 研究 AUD 恢复过程中受社会影响的大脑变化。 Kelly 博士的指导计划包括对学员进行以下方面的培训：1) AOD 疾病的临床方面； 2）设计和 实施 AOD 障碍研究； 3）准备科学论文和演示文稿； 4）写作补助金 应用程序； 5) 负责任地进行研究。他将通过个人和 小组会议、协作指导、角色建模以及与 MGH 临床研究部门的整合 职业发展办公室。凯利博士的职业发展计划包括提高他在社交方面的专业知识 神经科学，特别关注社会和环境因素在行为改变的神经科学中的作用 和 AOD 障碍恢复。这些活动将增强凯利博士的研究和指导能力。 该应用的公共卫生意义与确定酒精生物心理社会模型的需要有关 使用疾病缓解和恢复，以及培训下一代调查人员发展他们的技能的需要 需要对该患者群体进行有效的 POAR。