Mentoring in Patient-Oriented Addiction Research

以患者为导向的成瘾研究的指导

• 批准号: 9918816
• 负责人: JOHN F. KELLY
• 金额: $ 18.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9918816
• 关键词: Address; Adolescent; Adolescent and Young Adult; Alcoholics Anonymous; Alcohols; Applications Grants; Area; Award; Behavioral; Behavioral Mechanisms; Brain; Clinical; Clinical Research; Clinical Sciences; Cognitive; Communities; Data Collection; Data Set; Development; Development Plans; Discrimination; Disease; Disease remission; Ego; Environmental Risk Factor; Ethics; Evaluation; Fellowship; Fostering; Funding; General Hospitals; Goals; Grant; Group Meetings; Health Services Accessibility; Impulsivity; Individual; International; Intervention; Investigation; K-Series Research Career Programs; Learning; Massachusetts; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Neurosciences; Paper; Pathway Analysis; Pathway interactions; Patients; Peer Review; Pharmacotherapy; Phase III Clinical Trials; Policies; Premature Mortality; Productivity; Program Development; Psychiatry; Public Health; Publications; Recovery; Relapse; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Role; Running; Science; Scientific Inquiry; Secure; Series; Services; Social Network; Statistical Data Interpretation; Terminology; Testing; Time; Training; United States National Institutes of Health; Work; Writing; addiction; alcohol and other drug; alcohol research; alcohol use disorder; behavior change; biopsychosocial; burden of illness; career; career development; comorbidity; design; disability; improved; medical schools; mid-career faculty; next generation; novel; patient oriented; patient oriented research; patient population; peer; programs; psychologic; psychosocial; research study; responsible research conduct; role model; skills; social; social factors; social neuroscience; social stigma; symposium; treatment research

The primary goals of this K24 competitive renewal application are to enable Dr. John Kelly to: 1) conduct career development activities to enhance and extend his patient-oriented addiction research (POAR); and, 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will give Dr. Kelly protected time to devote to career development to increase the impact of his clinical alcohol and other drug (AOD) research and to intensive mentoring of junior clinical researchers, that would otherwise be spent on clinical and administrative duties. Dr. Kelly, Associate Professor of Psychiatry at Harvard Medical School, Director of the Massachusetts General Hospital (MGH) Recovery Research Institute, Program Director of the MGH Addiction Recovery Management Service, and Associate Director of the MGH Center for Addiction Medicine, has conducted POAR since 2001, with studies that identify and investigate successful pathways to recovery from AOD disorders, the impact of addiction terminology on stigma and treatment access, and the mechanisms of behavior change of AOD treatment and recovery support services. Dr. Kelly has accomplished the major goals of his initial K24 award. He has mentored more than 35 junior investigators, many of whom have secured F and K awards, and authored 79 publications, including 27 with a mentee as first author. He has conducted a series of studies that are informing how we treat adolescents and young adults with AOD disorders, and the clinical and public health utility of peer recovery support services to enhance long-term remission. He has expanded his policy work on addiction terminology to inform national debates to reframe how AOD disorders are addressed and decrease stigma and discrimination. Dr. Kelly's research plan for this renewal application includes continued work as a PI on NIH-funded treatment research and to serve as co-investigator on studies with mentees as PI. Furthermore, he plans to work on submitted proposals to: 1) identify the biopsychosocial markers of long-term relapse to AUD following initial remission; 2) conduct a Phase III clinical trial expand testing of a novel integrated psychosocial intervention for adolescent AOD disorders; and, 3) investigate socially-influenced brain changes in recovery from AUD. Dr. Kelly's mentoring plan includes training his mentees in: 1) clinical aspects of AOD disorders; 2) designing and implementing AOD disorder research studies; 3) preparing scientific papers and presentations; 4) writing grant applications; and, 5) the responsible conduct of research. He will accomplish this through a combination of individual and group meetings, collaborative mentoring, role modeling, and integration with the MGH Division of Clinical Research and Office of Career Development. Dr. Kelly's career development plan involves increasing his expertise in social neuroscience, focusing specifically on the role of social and environmental factors in the neuroscience of behavior change and AOD disorder recovery. These activities will enhance both Dr. Kelly's research and mentoring capacity. The public health significance of this application is related to the need to identify biopsychosocial models of alcohol use disorder remission and recovery, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.

此K24竞争性续约申请的主要目标是使John Kelly博士能够：1）进行职业生涯 发展活动，以加强和扩大他的以病人为导向的成瘾研究（POAR）;和，2）提供密集的 和高质量的指导，以早期职业调查员在POAR。K24更新将使凯利博士有时间保护 致力于职业发展，以增加他的临床酒精和其他药物（AOD）研究的影响，并加强 指导初级临床研究人员，否则将用于临床和行政职责。凯利医生， 哈佛医学院精神病学副教授，马萨诸塞州总医院（MGH）院长 恢复研究所，MGH成瘾恢复管理服务项目主任，助理 MGH成瘾医学中心主任，自2001年以来一直进行POAR，研究发现， 调查成功的途径，以恢复从AOD障碍，成瘾术语的影响耻辱， 治疗可及性，以及AOD治疗和康复支持服务的行为改变机制。凯利医生已经 完成了他最初的K24奖项的主要目标。他指导了超过35名初级调查员，其中许多人 获得F和K奖，并撰写了79篇出版物，其中27篇以学员为第一作者。他进行了 一系列研究为我们如何治疗患有AOD疾病的青少年和年轻人以及临床和 公共卫生利用同伴康复支助服务，以促进长期缓解。他扩大了政策工作 关于成瘾术语，为全国辩论提供信息，以重新确定如何解决AOD障碍并减少污名化 和歧视。凯利博士的研究计划，这项更新申请包括继续工作，作为一个PI对NIH资助的 治疗研究，并担任研究的共同研究者，学员作为PI。此外，他还计划在 提交了以下建议：1）确定初始缓解后AUD长期复发的生物心理社会标志物; 2)开展一项III期临床试验，扩大对青少年AOD的一种新的综合心理社会干预的测试 疾病;和，3）调查从AUD恢复中受社会影响的大脑变化。 凯利博士的指导计划包括培训他的学员：1）AOD疾病的临床方面; 2）设计和 实施AOD障碍研究; 3）准备科学论文和演示文稿; 4）撰写补助金 应用;以及，5）负责任的研究行为。他将通过个人和 小组会议，协作指导，角色建模，并与MGH临床研究部整合， 职业发展办公室。凯利博士的职业发展计划包括增加他在社会方面的专业知识 神经科学，特别关注社会和环境因素在行为改变神经科学中的作用 和AOD障碍恢复。这些活动将提高凯利博士的研究和指导能力。 这一应用的公共卫生意义与需要确定酒精的生物心理社会模型有关 使用障碍缓解和恢复，以及需要培训下一代调查人员，以发展他们的技能， 需要对该患者人群进行有效的POAR。