Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project

项目摘要/摘要 该项目将完成一种有前景的非手术用新型磁性眼镜的开发 治疗上睑下垂(睁眼麻痹)，随后在患者中进行临床试验。原因有很多。 上睑下垂，但在脑干中风、严重的头部创伤和肌无力后最为严重和致残 重症肌无力(一种神经肌肉疾病，常导致眼睑下垂和复视)。一种有效的非手术和 易于调整的治疗在中风和头部创伤后的早期恢复期以及 重症肌无力，病情全天变化。可用的非手术治疗，如 用胶带张开眼睛并在眼镜上用钢丝机械地抬起眼盖(拐杖)不是很好。 有效，因为它们打开眼睛，但不允许完全闭眼，导致不适和干燥的眼睛 眼表。我们正在开发的新型磁力装置(磁力提升器假体)由3个部件组成 嵌入硅胶的小磁铁(PDMS)，用薄的医用胶带和较大的磁铁固定在盖子上 眼睛上方，在眼镜的上眼线上。静磁力使盖子和面部抬高 闭眼肌肉可以克服磁力，让眼皮重新焕发活力。在临床试验之前，我们的目标是 通过开发一种方法来改善MLP，该方法允许患者使用拨盘调整磁力 该框架解决了利用可用的3-D头适当和一致地定位框架的需要 扫描和打印(为每个患者定制镜框)，提高盖子磁铁的粘附性 通过与生物粘合剂专家合作，提高患者自行盖上盖子的能力 通过开发一种磁铁涂抹工具。对于这些患者，一种有效的非手术方法是 这项提议的开发和临床试验目标将导致一种可以 直接翻译成临床使用。

Project Summary / Abstract This project will complete the development of a promising novel magnetic eyewear device for non-surgical treatment of ptosis (paralysis of eye opening) followed by a clinical trial in patients. There are many causes of ptosis, but it is most severe and disabling after brainstem stroke, severe head trauma, and in Myasthenia Gravis (a neuro-muscular disorder often causing droopy lids and double vision). An effective non-surgical and easily adjustable treatment is essential in the early recovery period after stroke and head trauma, and in Myasthenia Gravis where the condition varies throughout the day. Available non-surgical treatments such as taping the eye open and a wire on the glasses to mechanically elevate the lid (ptosis crutch) are not very effective because they open the eye but do not allow full eye closure, resulting in discomfort and drying of the ocular surface. The novel magnetic device we are developing (the magnetic levator prosthesis) consists of 3 small magnets embedded in silicone (PDMS) attached to the lid with thin medical tape and a larger magnet above the eye on the upper eyewire of the glasses. The static magnetic force elevates the lid and the facial muscles of eye closure can overcome the magnetic force, re-animating the eyelid. Prior to clinical trials we aim to improve the MLP by developing a method allowing the patient to adjust the magnetic force using a dial on the frame, address the need for proper and consistent positioning of the frame utilizing available 3-D head scanning and printing (custom frame for each patient), improve the adhesion properties of the lid magnets through collaboration with a bioadhesives expert, and improve the ability of the patient to self-apply the lid magnets through the development of an applicator tool. An effective non-surgical approach for these patients is long overdue and the development and clinical trial aims of this proposal would lead to a device which can be directly translated for clinical use.