Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project
使用钕磁铁系统治疗上睑下垂:波士顿 Blink-netic 项目
基本信息
- 批准号:10600609
- 负责人:
- 金额:$ 12.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAdhesionsBlepharoptosisBlinkingBostonBrain Stem InfarctionsClinicalClinical TrialsCollaborationsCraniocerebral TraumaCrutchesCustomDevelopmentDevicesDiplopiaEyeEyelid structureFacial MusclesHeadLeadMagnetismMechanicsMedicalMethodsMyasthenia GravisNeodymiumNeuromuscular DiseasesParalysedPatientsPositioning AttributePrincipal InvestigatorPrintingPropertyProsthesisPtosisRecoverySafetyScanningSiliconesSystemThinnessTranslatingexperimental studyimprovednovelocular surfacepost strokeprogramsprototypetool
项目摘要
Principal Investigator/Program Director: Houston, Kevin, E.
Project Summary / Abstract
This project will complete the development of a promising novel magnetic eyewear device for non-surgical
treatment of ptosis (paralysis of eye opening) followed by a clinical trial in patients.
There are many causes of ptosis, but it is most severe and disabling after brainstem stroke, severe head
trauma, and in Myasthenia Gravis (a neuro-muscular disorder often causing droopy lids and double vision). An
effective non-surgical and easily adjustable treatment is essential in the early recovery period after stroke and
head trauma, and in Myasthenia Gravis where the condition varies throughout the day. Available non-surgical
treatments such as taping the eye open and a wire on the glasses to mechanically elevate the lid (ptosis
crutch) are not very effective because they open the eye but do not allow full eye closure, resulting in
discomfort and drying of the ocular surface.
The novel magnetic device we are developing (the magnetic levator prosthesis) consists of 3 small magnets
embedded in silicone (PDMS) attached to the lid with thin medical tape and a larger magnet above the eye on
the upper eyewire of the glasses. The static magnetic force elevates the lid and the facial muscles of eye
closure can overcome the magnetic force, re-animating the eyelid.
Prior to clinical trials we aim to improve the MLP by developing a method allowing the patient to adjust the
magnetic force using a dial on the frame, address the need for proper and consistent positioning of the frame
utilizing available 3-D head scanning and printing (custom frame for each patient), improve the adhesion
properties of the lid magnets through collaboration with a bioadhesives expert, and improve the ability of the
patient to self-apply the lid magnets through the development of an applicator tool.
An effective non-surgical approach for these patients is long overdue and the development and clinical trial
aims of this proposal would lead to a device which can be directly translated for clinical use.
主要研究者/项目负责人:Houston,Kevin,E.
项目总结/摘要
该项目将完成一种有前途的新型非手术磁性眼镜设备的开发
治疗上睑下垂(睁眼麻痹),然后在患者中进行临床试验。
上睑下垂的原因很多,但最严重的是脑干中风后致残,严重的是头部
创伤和重症肌无力(一种经常引起眼睑下垂和复视的神经肌肉疾病)。一个
有效的非手术和易于调整的治疗在中风后的早期恢复期是必不可少的,
头部创伤,以及重症肌无力,其中病情全天变化。可用非手术
治疗方法,如用胶带将眼睛撑开,在眼镜上用金属丝机械地抬高眼睑(上睑下垂
拐杖)不是很有效,因为它们打开眼睛但不允许完全闭眼,导致
眼表的不适和干燥。
我们正在开发的新型磁性装置(磁性提肌假体)由3个小磁铁组成
嵌入硅胶(PDMS),用薄医用胶带固定在眼睑上,眼睛上方有一个更大的磁铁,
眼镜的上框静态磁力提升眼睑和眼部面部肌肉
闭合可以克服磁力,使眼睑恢复活力。
在临床试验之前,我们的目标是通过开发一种允许患者调整MLP的方法来改善MLP。
磁力使用表盘上的框架,解决了需要适当和一致的定位框架
利用可用的3D头部扫描和打印(为每位患者定制框架),改善粘合
通过与生物粘合剂专家合作,提高盖子磁铁的性能,并提高
患者通过开发敷贴器工具自行敷贴盖磁铁。
一种有效的非手术方法对这些患者来说是早就应该的,
该提案的目的是产生一种可以直接转化为临床使用的装置。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Feasibility of Magnetic Levator Prosthesis Frame Customization Using Craniofacial Scans and 3-D Printing.
- DOI:10.1167/tvst.11.10.34
- 发表时间:2022-10-03
- 期刊:
- 影响因子:3
- 作者:Houston, Kevin E.;Paschalis, Eleftherios I.
- 通讯作者:Paschalis, Eleftherios I.
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Kevin Edward Houston其他文献
Visual Field Expanding Peripheral Prisms Improve Detection of Roadside Pedestrians in Patients with Hemianopia
- DOI:
10.1016/j.apmr.2014.07.047 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:
- 作者:
Kevin Edward Houston;Eli Peli;Robert Goldstein;Alex Bowers - 通讯作者:
Alex Bowers
Kevin Edward Houston的其他文献
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{{ truncateString('Kevin Edward Houston', 18)}}的其他基金
Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project
使用钕磁铁系统治疗上睑下垂:波士顿 Blink-netic 项目
- 批准号:
10414062 - 财政年份:2018
- 资助金额:
$ 12.07万 - 项目类别:
Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project
使用钕磁铁系统治疗上睑下垂:波士顿 Blink-netic 项目
- 批准号:
10165729 - 财政年份:2018
- 资助金额:
$ 12.07万 - 项目类别:
Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project
使用钕磁铁系统治疗上睑下垂:波士顿 Blink-netic 项目
- 批准号:
10385085 - 财政年份:2018
- 资助金额:
$ 12.07万 - 项目类别:
Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project
使用钕磁铁系统治疗上睑下垂:波士顿 Blink-netic 项目
- 批准号:
10559279 - 财政年份:2018
- 资助金额:
$ 12.07万 - 项目类别:
Mobile medical application for cost-effective strabismus screening
用于经济有效的斜视筛查的移动医疗应用程序
- 批准号:
9347937 - 财政年份:2015
- 资助金额:
$ 12.07万 - 项目类别:
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