Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project

首席调查员/项目主任：休斯顿、凯文、E。 项目摘要/摘要 该项目将完成一种有前景的非手术用新型磁性眼镜的开发 治疗上睑下垂(睁眼麻痹)，随后在患者中进行临床试验。 引起上睑下垂的原因有很多，但在脑干中风后最为严重和致残，严重的是头部 创伤和重症肌无力(一种神经肌肉疾病，经常导致眼睑下垂和复视)。一个 有效的非手术和易于调整的治疗是卒中后早期恢复期和 头部创伤，以及重症肌无力，病情全天不同。提供非手术治疗 治疗，如用胶带将眼睛张开，并在眼镜上用钢丝机械地抬高眼盖(上睑下垂 拐杖)不是很有效，因为它们打开眼睛但不允许完全闭眼，导致 眼表不适和干燥。 我们正在开发的新型磁性装置(磁力提升器假体)由3个小磁铁组成。 嵌入硅胶(PDMS)，用薄的医用胶带和更大的磁铁固定在眼罩上 眼镜的上眼线。静磁力使眼睑和面部肌肉升高。 闭合可以克服磁力，让眼皮重新焕发活力。 在临床试验之前，我们的目标是通过开发一种允许患者调整MLP的方法来改善MLP 磁力在框架上使用刻度盘，满足框架正确和一致定位的需要 利用可用的3D头部扫描和打印(为每个患者定制帧)，提高粘附性 通过与生物粘合剂专家合作，提高盖子磁铁的性能，并提高 患者通过开发涂抹器工具自行涂抹盖子磁铁。 早该有一种有效的非手术方法来治疗这些患者，并进行了开发和临床试验。 这项提议的目的将导致一种可以直接翻译为临床使用的设备。

Principal Investigator/Program Director: Houston, Kevin, E. Project Summary / Abstract This project will complete the development of a promising novel magnetic eyewear device for non-surgical treatment of ptosis (paralysis of eye opening) followed by a clinical trial in patients. There are many causes of ptosis, but it is most severe and disabling after brainstem stroke, severe head trauma, and in Myasthenia Gravis (a neuro-muscular disorder often causing droopy lids and double vision). An effective non-surgical and easily adjustable treatment is essential in the early recovery period after stroke and head trauma, and in Myasthenia Gravis where the condition varies throughout the day. Available non-surgical treatments such as taping the eye open and a wire on the glasses to mechanically elevate the lid (ptosis crutch) are not very effective because they open the eye but do not allow full eye closure, resulting in discomfort and drying of the ocular surface. The novel magnetic device we are developing (the magnetic levator prosthesis) consists of 3 small magnets embedded in silicone (PDMS) attached to the lid with thin medical tape and a larger magnet above the eye on the upper eyewire of the glasses. The static magnetic force elevates the lid and the facial muscles of eye closure can overcome the magnetic force, re-animating the eyelid. Prior to clinical trials we aim to improve the MLP by developing a method allowing the patient to adjust the magnetic force using a dial on the frame, address the need for proper and consistent positioning of the frame utilizing available 3-D head scanning and printing (custom frame for each patient), improve the adhesion properties of the lid magnets through collaboration with a bioadhesives expert, and improve the ability of the patient to self-apply the lid magnets through the development of an applicator tool. An effective non-surgical approach for these patients is long overdue and the development and clinical trial aims of this proposal would lead to a device which can be directly translated for clinical use.