Management of Blepharoptosis with Neodymium Magnet Systems: The Boston Blink-netic Project

项目摘要/摘要 该项目将完成一种很有前途的新型磁性眼镜的开发 用于非手术治疗上睑下垂(睁眼麻痹)的装置，随后进行临床试验 在病人身上。 上睑下垂的原因有很多，但最严重的是脑干后的下垂。 中风，严重的头部创伤，以及重症肌无力(一种神经肌肉疾病，经常导致 眼睑下垂和复视)。一种有效的非手术和易于调整的治疗方法是 在中风和头部创伤后的早期恢复期以及重症肌无力中必不可少 那里的情况一整天都在变化。可用的非手术治疗，如胶带 眼睛张开和眼镜上用来机械抬起盖子的钢丝(上睑下垂拐杖)不是 非常有效，因为它们睁开眼睛但不允许完全闭上眼睛，导致 眼表不适和干燥。 我们正在开发的新型磁力装置(磁力提升器假体)由 3个嵌入硅胶(PDMS)的小磁铁，用薄的医用胶带固定在盖子上 眼镜上眼线上眼睛上方较大的磁铁。静磁力 抬高眼睑和面部肌肉的闭眼力可以克服磁力，恢复 使眼皮具有动画效果。 在临床试验之前，我们的目标是通过开发一种方法来改进MLP 患者使用框架上的刻度盘调整磁力，解决需要适当和 利用可用的3-D头部扫描和打印实现帧的一致定位(自定义 每个患者的框架)，通过以下方式改善盖子磁铁的粘附性 与生物粘合剂专家合作，提高患者自我应用 通过开发盖子磁铁的涂抹工具。 对于这些患者来说，早就应该有一种有效的非手术方法，而 这项提议的开发和临床试验目标将导致一种可以直接 翻译成临床使用。

Project Summary / Abstract This project will complete the development of a promising novel magnetic eyewear device for non-surgical treatment of ptosis (paralysis of eye opening) followed by a clinical trial in patients. There are many causes of ptosis, but it is most severe and disabling after brainstem stroke, severe head trauma, and in Myasthenia Gravis (a neuro-muscular disorder often causing droopy lids and double vision). An effective non-surgical and easily adjustable treatment is essential in the early recovery period after stroke and head trauma, and in Myasthenia Gravis where the condition varies throughout the day. Available non-surgical treatments such as taping the eye open and a wire on the glasses to mechanically elevate the lid (ptosis crutch) are not very effective because they open the eye but do not allow full eye closure, resulting in discomfort and drying of the ocular surface. The novel magnetic device we are developing (the magnetic levator prosthesis) consists of 3 small magnets embedded in silicone (PDMS) attached to the lid with thin medical tape and a larger magnet above the eye on the upper eyewire of the glasses. The static magnetic force elevates the lid and the facial muscles of eye closure can overcome the magnetic force, re- animating the eyelid. Prior to clinical trials we aim to improve the MLP by developing a method allowing the patient to adjust the magnetic force using a dial on the frame, address the need for proper and consistent positioning of the frame utilizing available 3-D head scanning and printing (custom frame for each patient), improve the adhesion properties of the lid magnets through collaboration with a bioadhesives expert, and improve the ability of the patient to self-apply the lid magnets through the development of an applicator tool. An effective non-surgical approach for these patients is long overdue and the development and clinical trial aims of this proposal would lead to a device which can be directly translated for clinical use.