Advanced characterisation of imaging probe products

成像探头产品的高级表征

基本信息

  • 批准号:
    10061490
  • 负责人:
  • 金额:
    $ 1.88万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Collaborative R&D
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    已结题

项目摘要

LightOx are a drug development company based in Newcastle upon Tyne that has made its light-activated products, known as LightOx Probes, available to other researchers to enable them to understand biological processes that occur in a cell.LightOx has shown that their Probe molecules are capable of emitting fluorescence when they are activated by light, allowing researchers to see where a Probe is situated inside a cell. However, while fluorescence measurements can show researchers where these molecules are localised, they cannot accurately tell us how much is there. To solve this problem, researchers around the world are beginning to demonstrate a new imaging technique, combined fluorescence and Raman imaging, that incorporates Raman (a form of light scattering) measurements along with light from fluorescence to answer both of these "Where?" and "How much?" questions. One disadvantage to this technique is that it requires specially-designed probes that are capable of both fluorescence and Raman measurements; there is no on-market probe that satisfies these conditions, significantly slowing the advancement of this fascinating technique that promises to help researchers answer complex biological questions.LightOx believe that many of their LightOx Probes exhibit unique structures that are capable of this new imaging technique, but they are a small company (10 employees) and lack the expertise and equipment required to demonstrate their probes' capabilities in these experiments. To solve this, LightOx have partnered with two of the world's leading technology facilities, the Central Laser Facility (CLF) and the National Physical Laboratory (NPL), on this A4I project to characterise the Raman properties of their LightOx probes and use these measurements to demonstrate utility in this new imaging technique. The CLF and NPL are equipped with state-of-the-art instrumentation to measure these properties, and these experiments will enable customers to use LightOx Probes to utilise combined fluorescence and Raman imaging and also allow LightOx to learn more about their novel technology.LightOx already sell LightOx Probes through a market-leading worldwide distributor and have noted that there are no probes currently marketed for combined fluorescence and Raman imaging. Hence, LightOx sees an opportunity to fill an emerging and potentially lucrative market gap, and we have partnered with the CLF and NPL to undertake this ambitious project that aims to establish a new application for LightOx products. These Probes have potential to enable researchers across the world to make new discoveries in fields such as cancer, cell biology and therapeutics.
LightOx是一家位于泰恩河畔纽卡斯尔的药物开发公司,该公司已将其光激活产品LightOx Probes提供给其他研究人员,使他们能够了解细胞中发生的生物过程。LightOx已经表明,他们的Probe分子在被光激活时能够发出荧光,使研究人员能够看到Probe位于细胞内的位置。然而,虽然荧光测量可以向研究人员展示这些分子的位置,但它们不能准确地告诉我们有多少。为了解决这个问题,世界各地的研究人员开始展示一种新的成像技术,结合荧光和拉曼成像,将拉曼(光散射的一种形式)测量沿着荧光的光,以回答这两个问题“在哪里?”和“多少钱?“问题。这种技术的一个缺点是它需要专门设计的探针,该探针能够进行荧光和拉曼测量;市场上没有满足这些条件的探针,这大大减缓了这项有望帮助研究人员回答复杂生物学问题的迷人技术的进步。LightOx相信他们的许多LightOx探针都具有能够实现这种新成像技术的独特结构,但他们是一家小公司(10名员工),缺乏在这些实验中证明其探测器能力所需的专业知识和设备。为了解决这个问题,LightOx与两个世界领先的技术设施,中央激光设施(CLF)和国家物理实验室(NPL)合作,在这个A4 I项目上测试他们的LightOx探针的拉曼特性,并使用这些测量来证明这种新成像技术的实用性。CLF和NPL配备了最先进的仪器来测量这些特性,这些实验将使客户能够使用LightOx探针来利用组合荧光和拉曼成像,也使LightOx能够更多地了解他们的新技术。LightOx已经通过市场领先的全球分销商销售LightOx探针,并指出目前还没有销售用于组合荧光和拉曼成像的探针。因此,LightOx看到了填补新兴且潜在利润丰厚的市场空白的机会,我们与CLF和NPL合作开展了这个雄心勃勃的项目,旨在为LightOx产品建立新的应用。这些探针有可能使世界各地的研究人员在癌症,细胞生物学和治疗学等领域取得新的发现。

项目成果

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其他文献

吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
  • DOI:
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    0
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LiDAR Implementations for Autonomous Vehicle Applications
  • DOI:
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    2021
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    0
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生命分子工学・海洋生命工学研究室
生物分子工程/海洋生物技术实验室
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
  • DOI:
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    0
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
  • 批准号:
    2908918
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
    2908693
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    $ 1.88万
  • 项目类别:
    Studentship

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