Current working project title: Development of super-resolution ultrasound imaging for tumour characterisation.

目前的工作项目名称：开发用于肿瘤表征的超分辨率超声成像。

• 批准号: 2841210
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2841210
• 关键词: Current; working; project; title; Development

This research project will investigate the clinical use of a high-performance imaging modality called Super Resolution Ultrasound (referred to as SRUS throughout this report) and its ability to probe micro-scale tissue morphology to characterise tumours. The fundamental question we will be trying to answer is 'What beneficial information can super-resolution ultrasound images provide to clinical staff during diagnosing, monitoring and treating particular diseases?'. Currently, the project's intended scope is to focus on tumour characterisation, as there have been several publications documenting potential links between the morphology of a tumour's microvasculature tissue and its disease severity. Additionally, there is evidence that other types of conditions could be studied by analysing the microvascular structure of particular tissues; micro-structures within the tongue potentially could reveal information about a patient's sepsis, and the project scope could be expanded at a later date to investigate this. Existing clinical procedures in the UK healthcare system, the widely available equipment and how well SRUS fits into the clinical workflow will all have to be considered in this research, and the methodology of the project will reflect these considerations. Initially, the project has been focused on using ultrasound phantoms and assessing the performance of the equipment and processing algorithms for producing SRUS images. Thereafter, the proposed methodology will focus on analysing existing clinical data sets as well as collecting more clinical data to better understand the information that can be extracted about tissue morphology, and attempting to develop a method of quantifying and comparing different tumour microstructures using existing histology analysis as a ground truth indicator.

该研究项目将研究称为超声超声（在本报告中称为SRU）的高性能成像方式的临床使用及其探测微尺度组织形态以表征肿瘤的能力。我们将试图回答的基本问题是“在诊断，监测和治疗特定疾病期间，超声超声图像可以为临床人员提供哪些有益信息？”。目前，该项目的预期范围是专注于肿瘤表征，因为已经有几个出版物记录了肿瘤的微​​脉管组织的形态与其疾病严重程度之间的潜在联系。此外，有证据表明，可以通过分析特定组织的微血管结构来研究其他类型的条件。舌头内的微结构可能会揭示有关患者败血症的信息，并且可以在以后扩大项目范围来调查此问题。在英国医疗保健系统中，现有的临床程序，可广泛可用的设备以及SRU在这项研究中都必须考虑在临床工作流程中，并且该项目的方法将反映这些考虑因素。最初，该项目一直集中在使用超声幻象上，并评估用于生成SRUS图像的设备和处理算法的性能。此后，提出的方法将重点放在分析现有的临床数据集以及收集更多的临床数据上，以更好地了解可以提取有关组织形态学的信息，并试图开发一种使用现有的组织学分析作为地面真实指标来量化和比较不同肿瘤微观结构的方法。