SARS-CoV-2 Genomic Surveillance in North Louisiana

路易斯安那州北部的 SARS-CoV-2 基因组监测

• 批准号: 10381353
• 负责人: Christopher G Kevil
• 金额: $ 73万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381353
• 关键词: 2019-nCoV; Agreement; Arkansas; Biologic Characteristic; Biology; COVID-19; COVID-19 pandemic; COVID-19 patient; COVID-19 surveillance; COVID-19 testing; COVID-19 vaccine; Cardiology; Cardiopulmonary; Cardiovascular Diseases; Cells; Centers for Disease Control and Prevention (U.S.); Clinical Research; Collaborations; Communication; Communities; Community Health; Contracts; Critical Care; Data; Diagnostic; Disease; Disease Outbreaks; Dose; Economics; Evolution; Exhibits; FDA approved; Faculty; Foundations; Funding; Genomics; Health; Health care facility; Hospitals; Humoral Immunities; Immunology; Individual; Infection; Laboratories; Louisiana; Mass Vaccinations; Mutation; Outcome; Oxidation-Reduction; Pathogenesis; Pathogenicity; Pathologic Processes; Patients; Personal Satisfaction; Persons; Positioning Attribute; Public Health; Quantitative Reverse Transcriptase PCR; Research; Risk Factors; Role; SARS-CoV-2 B.1.1.7; SARS-CoV-2 genome; SARS-CoV-2 infection; SARS-CoV-2 positive; SARS-CoV-2 variant; Site; Specimen; Testing; Texas; Translations; Tropism; United States; United States National Institutes of Health; Vaccinated; Vaccination; Vaccines; Variant; Viral; Viral Genome; Virus; Work; data sharing; genome sequencing; novel; pandemic disease; programs; response; severe COVID-19; social; surveillance data; testing services; transmission process; vaccine evaluation; variants of concern; viral genomics

ABSTRACT Viral genomic surveillance is critical for identification of SARS-CoV-2 variants that exhibit biological characteristics of concern for public health, such as escape from humoral immunity, enhanced transmissibility, and/or increased pathogenic potential. This competitive revision proposal represents a collaboration between two LSU Health Shreveport (LSUHS) CoBRE’s (Center for Redox Biology and Cardiovascular Disease [CRBCD] and Center for Applied Immunology and Pathological Processes [CAIPP]) and leverages established institutional programs including the Center for Emerging Viral Threats’ (CEVT) CLIA/CAP certified reference laboratory, ongoing COVID-19 clinical research, community mass vaccination and testing services, and a highly productive viral genome sequencing program that have served North and Central Louisiana throughout the pandemic. Additionally, LSUHS is in active partner with the Louisiana Department of Health (LDH) for these efforts and has a strong foundation for translation of viral genomic surveillance data into favorable public health outcomes, such as protection of vulnerable communities and targeted mitigation steps against variants of concern. As such, this competitive revision supplement will pursue the following two specific aims: Aim 1) Establish rapid SARS-CoV-2 viral genome sequencing and data sharing prioritized by re-infections and infections of vaccine recipients; and Aim 2) Perform SARS-CoV-2 viral genome sequencing and data sharing of moderate to severe COVID-19 patients with predisposing risk factors and/or cardiopulmonary complications. Together, this work will greatly enhance genomic surveillance of SARS-CoV-2 in Louisiana, East Texas, and Southern Arkansas to benefit US public health and advance research regarding this devastating virus.

摘要 病毒基因组监测对于鉴定SARS-CoV-2变异体至关重要， 关注公共卫生的特征，如逃避体液免疫，增强 传染性和/或增加的致病潜力。此竞争性修订提案代表 两个路易斯安那州立大学健康什里夫波特（LSUHS）CoBRE（氧化还原生物学中心和 心血管疾病[CRBCD]和应用免疫学和病理过程中心 [CAIPP]），并利用现有的机构计划，包括新兴病毒中心 威胁（CEVT）CLIA/CAP认证的参考实验室，正在进行的COVID-19临床研究， 社区大规模疫苗接种和检测服务，以及高效的病毒基因组测序 在整个大流行期间为路易斯安那州北部和中部提供服务的计划。此外，LSUHS 是在积极的合作伙伴与路易斯安那州卫生部（LDH）为这些努力，并有一个强大的 将病毒基因组监测数据转化为有利的公共卫生结果的基础， 作为保护脆弱社区和针对令人关切的变种采取有针对性的缓解措施。作为 因此，本竞争性修订补充文件将追求以下两个具体目标：目标1）建立 快速SARS-CoV-2病毒基因组测序和数据共享，优先考虑再感染， 目的2）进行SARS-CoV-2病毒基因组测序， 具有易感风险因素的中重度COVID-19患者的数据共享和/或 心肺并发症总之，这项工作将极大地加强基因组监测， SARS-CoV-2在路易斯安那州、得克萨斯州东部和阿肯色州南部，以造福美国公共卫生和 关于这种毁灭性病毒的研究进展