Center for Redox Biology and Cardiovascular Disease

项目摘要 心血管疾病是美国死亡和残疾的主要原因， 对我国南部地区的影响。根据2016年美国健康排名年度报告， 路易斯安那州的心血管死亡率为46/50，心脏病死亡率为48/50，是美国最低的心脏病死亡率。 全国的心血管健康此外，心血管疾病发病率27年来首次上升 死亡人数在全国范围内增加，突出了心血管研究的规模和重要性。 虽然已经实现了心血管治疗的进步，但许多心血管疾病机制 仍然知之甚少。很明显，心脏和血管氧化应激的变化以及 抗氧化防御，即所谓的“氧化还原平衡”，在疾病的发生和传播中起着关键作用。 然而，氧化还原生物学的改变控制细胞和分子反应的特定方式， 心血管疾病在很大程度上仍是未知的。心血管疾病和科学中心， 路易斯安那州立大学健康科学中心什里夫波特已经召集了具有最先进知识的调查人员， 跨几个部门的研究专业知识，以解决氧化还原生物学分子机制， 心血管病理生理学该提案的目的是开发和建立一个COBRE中心， 氧化还原生物学和心血管疾病与国家认可的丰富的培训环境， 初级教师，提高国家奖项的研究项目的竞争力。单独的初级 根据项目与研究主题的相关性、研究的新奇、 关于氧化还原生物学和心血管疾病的主题，以及他们实现计划的潜在能力 独立拟议的项目将提供新的理解所需的氧化还原生物学机制 心脏和血管（dys）功能的支持，从先进的，最先进的动物模型和氧化还原 分子病理学研究中心研究和专业发展计划也是 这将在该领域提供持续增长和领导力。

Project Abstract Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. According to the 2016 America's Health Rankings Annual Report, Louisiana ranks 46/50 in cardiovascular deaths and 48/50 in heart disease placing it in the lowest categories of cardiovascular health across the nation. Moreover, for the first time in 27 years, the rate of cardiovascular deaths increased across the nation highlighting the magnitude and importance of cardiovascular research. While advances in cardiovascular treatments have been realized, many cardiovascular disease mechanisms remain poorly understood. It has become clear that changes in heart and vascular oxidative stress and antioxidant defenses, the so called `redox balance', plays critical roles in disease initiation and propagation. However, specific ways that alterations in redox biology control cellular and molecular responses leading to cardiovascular disease remains largely unknown. The Center for Cardiovascular Diseases and Sciences at LSU Health Sciences Center Shreveport has assembled investigators with state of the art knowledge and research expertise across several departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this proposal is to develop and establish a COBRE Center for Redox Biology and Cardiovascular Disease with a nationally recognized enriched training environment for junior faculty that advances the competitiveness of research programs for national awards. Individual primary projects have been carefully chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve program independence. The proposed projects will provide new understanding of redox biology mechanisms required for cardiac and vascular (dys)function with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership in this area.