Center for Redox Biology and Cardiovascular Disease

项目摘要 心血管疾病是美国人死亡和残疾的主要原因， 对该国南部地区的影响。根据2016年美国健康排行榜年度报告， 路易斯安那州在心血管疾病死亡率中排名46/50，在心脏病死亡率中排名48/50，是世界上最低的 全国范围内的心血管健康。此外，27年来首次出现了心血管疾病 全国各地的死亡人数都在增加，这凸显了心血管研究的重要性和重要性。 虽然心血管治疗的进展已经实现，但许多心血管疾病的机制 人们对此仍然知之甚少。已经很明显，心脏和血管氧化应激的变化和 抗氧化剂防御，即所谓的“氧化还原平衡”，在疾病的发生和传播中起着关键作用。 然而，氧化还原生物学中的改变控制细胞和分子反应的具体方式导致 心血管疾病在很大程度上仍不为人所知。心血管疾病和科学中心 路易斯安那州立大学健康科学中心什里夫波特召集了拥有最先进知识和 跨多个部门的研究专业知识，以解决氧化还原生物分子机制，有助于 心血管病理生理学。这项提议的目的是开发和建立一个科布雷中心，用于 氧化还原生物学和心血管疾病具有国家认可的丰富的培训环境 初级教员，提高国家奖项研究项目的竞争力。个别初选 项目是根据它们与研究主题的相关性、研究的新颖性而精心选择的 关于氧化还原生物学和心血管疾病的主题，以及他们实现计划的潜在能力 独立。拟议的项目将提供对所需氧化还原生物学机制的新理解。 在先进、最先进的动物模型和氧化还原的支持下，实现心脏和血管(Dys)功能 分子病理学研究核心设施。研究和职业发展计划也是 这将提供该领域的持续增长和领导地位。

Project Abstract Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. According to the 2016 America's Health Rankings Annual Report, Louisiana ranks 46/50 in cardiovascular deaths and 48/50 in heart disease placing it in the lowest categories of cardiovascular health across the nation. Moreover, for the first time in 27 years, the rate of cardiovascular deaths increased across the nation highlighting the magnitude and importance of cardiovascular research. While advances in cardiovascular treatments have been realized, many cardiovascular disease mechanisms remain poorly understood. It has become clear that changes in heart and vascular oxidative stress and antioxidant defenses, the so called `redox balance', plays critical roles in disease initiation and propagation. However, specific ways that alterations in redox biology control cellular and molecular responses leading to cardiovascular disease remains largely unknown. The Center for Cardiovascular Diseases and Sciences at LSU Health Sciences Center Shreveport has assembled investigators with state of the art knowledge and research expertise across several departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this proposal is to develop and establish a COBRE Center for Redox Biology and Cardiovascular Disease with a nationally recognized enriched training environment for junior faculty that advances the competitiveness of research programs for national awards. Individual primary projects have been carefully chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve program independence. The proposed projects will provide new understanding of redox biology mechanisms required for cardiac and vascular (dys)function with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership in this area.