Center for Redox Biology and Cardiovascular Disease

项目摘要 心血管疾病是美国人死亡和残疾的主要原因， 对该国南部地区的影响。路易斯安那州深受心血管疾病的影响， 该州近四分之一的死亡都归因于此。虽然心血管治疗的进展一直是 认识到，许多疾病机制仍然知之甚少。越来越清楚的是，变化 在心脏和血管的氧化应激和抗氧化防御中，所谓的“氧化还原平衡”起着至关重要的作用。 在疾病的引发和传播中。然而，氧化还原生物学控制的特定疾病机制 路径仍然不明确，这需要在这一领域进一步学习和研究。氧化还原中心 路易斯安那州立大学健康什里夫波特生物与心血管疾病(CRBCD)第一阶段科布雷汇聚一堂 众多初级调查人员在不同部门拥有最先进的知识和专业知识 阐述氧化还原生物学分子机制对心血管病理生理学的影响。这样做的目的是 第二阶段的建议是继续发展CRBCD中心，并继续招聘初级教员到 提高重大科研资助项目竞争力的计划和机构。个别初级教员 主要项目是根据它们与研究主题的相关性、研究主题的新颖性而选择的 关于氧化还原生物学和心血管疾病，以及他们实现独立专业的潜在能力 研究经费。尖端研究核心设施已经开始并将继续发展，以满足需求 科布雷项目、机构和全国各地的其他机构。CRBCD Cobre也受益匪浅 来自一个世界级的咨询委员会，该委员会将继续提供意见和建议 第二阶段计划。总之，建议的项目将提供对氧化还原生物学的深入了解。 在先进的最先进动物的支持下心血管疾病的病理生理机制 模型和氧化还原分子病理学研究的核心设施。研究和专业发展 还提出了为所有相关参与者提供持续增长和领导力的计划，并 实习生。

PROJECT ABSTRACT Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. Louisiana is substantially affected by cardiovascular disease with nearly one quarter of deaths in the state attributed to it. While advances in cardiovascular treatments have been realized, many disease mechanisms remain poorly understood. It has become increasingly clear that changes in heart and vascular oxidant stress and antioxidant defenses, the so called ‘redox balance’, plays critical roles in disease initiation and propagation. However, specific disease mechanisms controlled by redox biology pathways remains poorly defined, which requires further study and research in this area. The Center for Redox Biology and Cardiovascular Disease (CRBCD) Phase 1 CoBRE at LSU Health Shreveport brought together numerous junior investigators with state-of-the-art knowledge and expertise across different departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this Phase 2 proposal is to continue growth of the CRBCD CoBRE and continue recruitment of junior faculty to the program and institution to increase competitiveness of major research grant programs. Individual junior faculty primary projects have been chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve independent major research funding. Cutting edge research core facilities have begun and will continue to grow to serve the needs of the CoBRE program, institution, and others across the nation. The CRBCD CoBRE has also greatly benefitted from a world class advisory committee that remains committed to continue providing input and advise throughout the Phase 2 program. Together, the proposed projects will provide advanced understanding of redox biology pathophysiology mechanisms during cardiovascular disease with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership for all associated participants and trainees.