Center for Redox Biology and Cardiovascular Disease
Center for Redox Biology and Cardiovascular Disease
批准号:
10715402
负责人:
Christopher G Kevil
金额:
$214.15万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-02-01 至 2028-06-30
关键词:
AchievementAddressAdvisory CommitteesAffectAnimal ModelAntioxidantsAreaBiologyBlood VesselsCardiovascular DiseasesCardiovascular PathologyCardiovascular systemCause of DeathCenters of Research ExcellenceCessation of lifeCore FacilityCountryDevelopmentDiseaseEnvironmentEquilibriumExtramural ActivitiesFacultyFunctional disorderFundingFutureGoalsGrantGrowthHealthHeartHeart DiseasesHistologyIndividualInstitutionKnowledgeLeadershipLouisianaMentorsMentorshipMolecularMolecular BiologyMorbidity - disease rateOxidation-ReductionParticipantPathway interactionsPersonsPhasePlayPoliciesProcessProductivityProgram DevelopmentRegulationReportingResearchResearch InfrastructureResearch PersonnelResearch Project GrantsRoleScientific Advances and AccomplishmentsSignal TransductionTeacher Professional DevelopmentTrainingTraining ProgramsUnited StatesVascular Diseasescohortdisabilityeducation researchfaculty researchinsightmeetingsmolecular pathologymortalityoxidant stressprogramsrecruit
中文摘要
项目摘要
英文摘要
PROJECT ABSTRACT
Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional
effect on southern regions of the country. Louisiana is substantially affected by cardiovascular disease with
nearly one quarter of deaths in the state attributed to it. While advances in cardiovascular treatments have been
realized, many disease mechanisms remain poorly understood. It has become increasingly clear that changes
in heart and vascular oxidant stress and antioxidant defenses, the so called ‘redox balance’, plays critical roles
in disease initiation and propagation. However, specific disease mechanisms controlled by redox biology
pathways remains poorly defined, which requires further study and research in this area. The Center for Redox
Biology and Cardiovascular Disease (CRBCD) Phase 1 CoBRE at LSU Health Shreveport brought together
numerous junior investigators with state-of-the-art knowledge and expertise across different departments to
address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this
Phase 2 proposal is to continue growth of the CRBCD CoBRE and continue recruitment of junior faculty to the
program and institution to increase competitiveness of major research grant programs. Individual junior faculty
primary projects have been chosen based on their relevance to the research theme, novelty of the research topic
regarding redox biology and cardiovascular disease, and their potential ability to achieve independent major
research funding. Cutting edge research core facilities have begun and will continue to grow to serve the needs
of the CoBRE program, institution, and others across the nation. The CRBCD CoBRE has also greatly benefitted
from a world class advisory committee that remains committed to continue providing input and advise throughout
the Phase 2 program. Together, the proposed projects will provide advanced understanding of redox biology
pathophysiology mechanisms during cardiovascular disease with support from advanced, state of the art animal
models and redox molecular pathology research core facilities. Research and professional development
programs are also proposed that will provide continued growth and leadership for all associated participants and
trainees.
期刊论文(68)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1016/j.ebiom.2020.103161
发表时间:
2021-01
期刊:
EBioMedicine
影响因子:
11.1
作者:
[Barzegar M, Wang Y, Eshaq RS, Yun JW, Boyer CJ, Cananzi SG, White LA, Chernyshev O, Kelley RE, Minagar A, Stokes KY, Lu XH, Alexander JS]
通讯作者:
Alexander JS
A collaborative approach to improve representation in viral genomic surveillance.
提高病毒基因组监测代表性的协作方法。
DOI:
10.1101/2022.10.19.512816
发表时间:
2022
期刊:
bioRxiv : the preprint server for biology
影响因子:
--
作者:
[Kim,PaulY, Kim,AudreyY, Newman,JamieJ, Cella,Eleonora, Bishop,ThomasC, Huwe,PeterJ, Uchakina,OlgaN, McKallip,RobertJ, Mack,VanceL, Hill,MarnieP, Ogungbe,IfedayoVictor, Adeyinka,Olawale, Jones,Samuel, Ware,Gregory, Carroll,Jennifer]
通讯作者:
Carroll,Jennifer
Collection and Isolation of CD14+ Primary Human Monocytes Via Dual Density Gradient Centrifugation as a Model System to Study Human Cytomegalovirus Infection and Pathogenesis.
通过双密度梯度离心收集和分离 CD14 原代人类单核细胞作为研究人类巨细胞病毒感染和发病机制的模型系统。
DOI:
10.1007/978-1-0716-1111-1_6
发表时间:
2021
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
作者:
[Mosher,BaileyS, Fulkerson,HeatherL, Yurochko,AndrewD]
通讯作者:
Yurochko,AndrewD
DOI:
10.1016/j.bpa.2020.12.003
发表时间:
2021-10
期刊:
Best practice & research. Clinical anaesthesiology
影响因子:
--
作者:
[Kaye AD, Cornett EM, Brondeel KC, Lerner ZI, Knight HE, Erwin A, Charipova K, Gress KL, Urits I, Urman RD, Fox CJ, Kevil CG]
通讯作者:
Kevil CG
DOI:
10.1038/s41398-022-01837-w
发表时间:
2022-02-22
期刊:
Translational psychiatry
影响因子:
6.8
作者:
[Nahar L, Kaufman SE, Davis PG, Saunders SL, Disbrow EA, Patterson JC, Nam HW]
通讯作者:
Nam HW
共 39 条
Administrative Core
-
批准号:10715403
-
项目类别:
-
资助金额:$43.8万
-
财政年份:2023
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10630127
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10206260
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10427218
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10007007
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
SARS-CoV-2 Genomic Surveillance in North Louisiana
-
批准号:10595390
-
项目类别:
-
资助金额:$73.0万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Administration and Mentorship Core
-
批准号:10331748
-
项目类别:
-
资助金额:$39.28万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Center for Redox Biology and Cardiovascular Disease
-
批准号:9763036
-
项目类别:
-
资助金额:$26.34万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Center for Redox Biology and Cardiovascular Disease
-
批准号:10331747
-
项目类别:
-
资助金额:$208.74万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
SARS-CoV-2 Genomic Surveillance in North Louisiana
-
批准号:10381353
-
项目类别:
-
资助金额:$73.0万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
-
批准号:8463031
-
项目类别:
-
资助金额:$34.27万
-
财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
-
批准号:8656802
-
项目类别:
-
资助金额:$35.28万
-
财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
-
批准号:8274176
-
项目类别:
-
资助金额:$36.0万
-
财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7471450
-
项目类别:
-
资助金额:$35.11万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7662263
-
项目类别:
-
资助金额:$34.81万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7143265
-
项目类别:
-
资助金额:$36.25万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7899834
-
项目类别:
-
资助金额:$34.81万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7266184
-
项目类别:
-
资助金额:$35.2万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ROLE OF MAC-1/ICAM-1 INTERACTIONS IN VASCULITIS
-
批准号:6530601
-
项目类别:
-
资助金额:$1.29万
-
财政年份:2002
-
负责人:Christopher G Kevil
-
依托单位:
ROLE OF MAC-1/ICAM-1 INTERACTIONS IN VASCULITIS
-
批准号:6363477
-
项目类别:
-
资助金额:$4.02万
-
财政年份:2001
-
负责人:Christopher G Kevil
-
依托单位:
海外基金