Center for Redox Biology and Cardiovascular Disease

氧化还原生物学和心血管疾病中心

• 批准号: 10715402
• 负责人: Christopher G Kevil
• 金额: $ 214.15万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715402
• 关键词: Achievement; Address; Advisory Committees; Affect; Animal Model; Antioxidants; Area; Biology; Blood Vessels; Cardiovascular Diseases; Cardiovascular Pathology; Cardiovascular system; Cause of Death; Centers of Research Excellence; Cessation of life; Core Facility; Country; Development; Disease; Environment; Equilibrium; Extramural Activities; Faculty; Functional disorder; Funding; Future; Goals; Grant; Growth; Health; Heart; Heart Diseases; Histology; Individual; Institution; Knowledge; Leadership; Louisiana; Mentors; Mentorship; Molecular; Molecular Biology; Morbidity - disease rate; Oxidation-Reduction; Participant; Pathway interactions; Persons; Phase; Play; Policies; Process; Productivity; Program Development; Regulation; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Scientific Advances and Accomplishments; Signal Transduction; Teacher Professional Development; Training; Training Programs; United States; Vascular Diseases; cohort; disability; education research; faculty research; insight; meetings; molecular pathology; mortality; oxidant stress; programs; recruit

PROJECT ABSTRACT Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. Louisiana is substantially affected by cardiovascular disease with nearly one quarter of deaths in the state attributed to it. While advances in cardiovascular treatments have been realized, many disease mechanisms remain poorly understood. It has become increasingly clear that changes in heart and vascular oxidant stress and antioxidant defenses, the so called ‘redox balance’, plays critical roles in disease initiation and propagation. However, specific disease mechanisms controlled by redox biology pathways remains poorly defined, which requires further study and research in this area. The Center for Redox Biology and Cardiovascular Disease (CRBCD) Phase 1 CoBRE at LSU Health Shreveport brought together numerous junior investigators with state-of-the-art knowledge and expertise across different departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this Phase 2 proposal is to continue growth of the CRBCD CoBRE and continue recruitment of junior faculty to the program and institution to increase competitiveness of major research grant programs. Individual junior faculty primary projects have been chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve independent major research funding. Cutting edge research core facilities have begun and will continue to grow to serve the needs of the CoBRE program, institution, and others across the nation. The CRBCD CoBRE has also greatly benefitted from a world class advisory committee that remains committed to continue providing input and advise throughout the Phase 2 program. Together, the proposed projects will provide advanced understanding of redox biology pathophysiology mechanisms during cardiovascular disease with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership for all associated participants and trainees.

项目摘要

项目成果

Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.

• DOI: 10.1016/j.ebiom.2020.103161
• 发表时间: 2021-01
• 期刊: EBioMedicine
• 影响因子: 11.1
• 作者: Barzegar M;Wang Y;Eshaq RS;Yun JW;Boyer CJ;Cananzi SG;White LA;Chernyshev O;Kelley RE;Minagar A;Stokes KY;Lu XH;Alexander JS
• 通讯作者: Alexander JS

A collaborative approach to improve representation in viral genomic surveillance.

提高病毒基因组监测代表性的协作方法。

• DOI: 10.1101/2022.10.19.512816
• 发表时间: 2022
• 期刊: bioRxiv : the preprint server for biology
• 作者: Kim,PaulY;Kim,AudreyY;Newman,JamieJ;Cella,Eleonora;Bishop,ThomasC;Huwe,PeterJ;Uchakina,OlgaN;McKallip,RobertJ;Mack,VanceL;Hill,MarnieP;Ogungbe,IfedayoVictor;Adeyinka,Olawale;Jones,Samuel;Ware,Gregory;Carroll,Jennifer
• 通讯作者: Carroll,Jennifer

Collection and Isolation of CD14+ Primary Human Monocytes Via Dual Density Gradient Centrifugation as a Model System to Study Human Cytomegalovirus Infection and Pathogenesis.

通过双密度梯度离心收集和分离 CD14 原代人类单核细胞作为研究人类巨细胞病毒感染和发病机制的模型系统。

• DOI: 10.1007/978-1-0716-1111-1_6
• 发表时间: 2021
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Mosher,BaileyS;Fulkerson,HeatherL;Yurochko,AndrewD
• 通讯作者: Yurochko,AndrewD

Biology of COVID-19 and related viruses: Epidemiology, signs, symptoms, diagnosis, and treatment.

• DOI: 10.1016/j.bpa.2020.12.003
• 发表时间: 2021-10
• 期刊: Best practice & research. Clinical anaesthesiology
• 作者: Kaye AD;Cornett EM;Brondeel KC;Lerner ZI;Knight HE;Erwin A;Charipova K;Gress KL;Urits I;Urman RD;Fox CJ;Kevil CG
• 通讯作者: Kevil CG

Blood glutamine synthetase signaling in alcohol use disorder and racial disparity.

• DOI: 10.1038/s41398-022-01837-w
• 发表时间: 2022-02-22
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Nahar L;Kaufman SE;Davis PG;Saunders SL;Disbrow EA;Patterson JC;Nam HW
• 通讯作者: Nam HW