Center for Redox Biology and Cardiovascular Disease
Center for Redox Biology and Cardiovascular Disease
批准号:
10715402
负责人:
Christopher G Kevil
金额:
$214.15万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-02-01 至 2028-06-30
关键词:
AchievementAddressAdvisory CommitteesAffectAnimal ModelAntioxidantsAreaBiologyBlood VesselsCardiovascular DiseasesCardiovascular PathologyCardiovascular systemCause of DeathCenters of Research ExcellenceCessation of lifeCore FacilityCountryDevelopmentDiseaseEnvironmentEquilibriumExtramural ActivitiesFacultyFunctional disorderFundingFutureGoalsGrantGrowthHealthHeartHeart DiseasesHistologyIndividualInstitutionKnowledgeLeadershipLouisianaMentorsMentorshipMolecularMolecular BiologyMorbidity - disease rateOxidation-ReductionParticipantPathway interactionsPersonsPhasePlayPoliciesProcessProductivityProgram DevelopmentRegulationReportingResearchResearch InfrastructureResearch PersonnelResearch Project GrantsRoleScientific Advances and AccomplishmentsSignal TransductionTeacher Professional DevelopmentTrainingTraining ProgramsUnited StatesVascular Diseasescohortdisabilityeducation researchfaculty researchinsightmeetingsmolecular pathologymortalityoxidant stressprogramsrecruit
中文摘要
项目摘要
心血管疾病是美国人死亡和残疾的主要原因,
对该国南部地区的影响。路易斯安那州深受心血管疾病的影响,
该州近四分之一的死亡都归因于此。虽然心血管治疗的进展一直是
认识到,许多疾病机制仍然知之甚少。越来越清楚的是,变化
在心脏和血管的氧化应激和抗氧化防御中,所谓的“氧化还原平衡”起着至关重要的作用。
在疾病的引发和传播中。然而,氧化还原生物学控制的特定疾病机制
路径仍然不明确,这需要在这一领域进一步学习和研究。氧化还原中心
路易斯安那州立大学健康什里夫波特生物与心血管疾病(CRBCD)第一阶段科布雷汇聚一堂
众多初级调查人员在不同部门拥有最先进的知识和专业知识
阐述氧化还原生物学分子机制对心血管病理生理学的影响。这样做的目的是
第二阶段的建议是继续发展CRBCD中心,并继续招聘初级教员到
提高重大科研资助项目竞争力的计划和机构。个别初级教员
主要项目是根据它们与研究主题的相关性、研究主题的新颖性而选择的
关于氧化还原生物学和心血管疾病,以及他们实现独立专业的潜在能力
研究经费。尖端研究核心设施已经开始并将继续发展,以满足需求
科布雷项目、机构和全国各地的其他机构。CRBCD Cobre也受益匪浅
来自一个世界级的咨询委员会,该委员会将继续提供意见和建议
第二阶段计划。总之,建议的项目将提供对氧化还原生物学的深入了解。
在先进的最先进动物的支持下心血管疾病的病理生理机制
模型和氧化还原分子病理学研究的核心设施。研究和专业发展
还提出了为所有相关参与者提供持续增长和领导力的计划,并
实习生。
英文摘要
PROJECT ABSTRACT
Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional
effect on southern regions of the country. Louisiana is substantially affected by cardiovascular disease with
nearly one quarter of deaths in the state attributed to it. While advances in cardiovascular treatments have been
realized, many disease mechanisms remain poorly understood. It has become increasingly clear that changes
in heart and vascular oxidant stress and antioxidant defenses, the so called ‘redox balance’, plays critical roles
in disease initiation and propagation. However, specific disease mechanisms controlled by redox biology
pathways remains poorly defined, which requires further study and research in this area. The Center for Redox
Biology and Cardiovascular Disease (CRBCD) Phase 1 CoBRE at LSU Health Shreveport brought together
numerous junior investigators with state-of-the-art knowledge and expertise across different departments to
address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this
Phase 2 proposal is to continue growth of the CRBCD CoBRE and continue recruitment of junior faculty to the
program and institution to increase competitiveness of major research grant programs. Individual junior faculty
primary projects have been chosen based on their relevance to the research theme, novelty of the research topic
regarding redox biology and cardiovascular disease, and their potential ability to achieve independent major
research funding. Cutting edge research core facilities have begun and will continue to grow to serve the needs
of the CoBRE program, institution, and others across the nation. The CRBCD CoBRE has also greatly benefitted
from a world class advisory committee that remains committed to continue providing input and advise throughout
the Phase 2 program. Together, the proposed projects will provide advanced understanding of redox biology
pathophysiology mechanisms during cardiovascular disease with support from advanced, state of the art animal
models and redox molecular pathology research core facilities. Research and professional development
programs are also proposed that will provide continued growth and leadership for all associated participants and
trainees.
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DOI:
10.1016/j.ebiom.2020.103161
发表时间:
2021-01
期刊:
EBioMedicine
影响因子:
11.1
作者:
[Barzegar M, Wang Y, Eshaq RS, Yun JW, Boyer CJ, Cananzi SG, White LA, Chernyshev O, Kelley RE, Minagar A, Stokes KY, Lu XH, Alexander JS]
通讯作者:
Alexander JS
A collaborative approach to improve representation in viral genomic surveillance.
提高病毒基因组监测代表性的协作方法。
DOI:
10.1101/2022.10.19.512816
发表时间:
2022
期刊:
bioRxiv : the preprint server for biology
影响因子:
--
作者:
[Kim,PaulY, Kim,AudreyY, Newman,JamieJ, Cella,Eleonora, Bishop,ThomasC, Huwe,PeterJ, Uchakina,OlgaN, McKallip,RobertJ, Mack,VanceL, Hill,MarnieP, Ogungbe,IfedayoVictor, Adeyinka,Olawale, Jones,Samuel, Ware,Gregory, Carroll,Jennifer]
通讯作者:
Carroll,Jennifer
Collection and Isolation of CD14+ Primary Human Monocytes Via Dual Density Gradient Centrifugation as a Model System to Study Human Cytomegalovirus Infection and Pathogenesis.
通过双密度梯度离心收集和分离 CD14 原代人类单核细胞作为研究人类巨细胞病毒感染和发病机制的模型系统。
DOI:
10.1007/978-1-0716-1111-1_6
发表时间:
2021
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
作者:
[Mosher,BaileyS, Fulkerson,HeatherL, Yurochko,AndrewD]
通讯作者:
Yurochko,AndrewD
DOI:
10.1016/j.bpa.2020.12.003
发表时间:
2021-10
期刊:
Best practice & research. Clinical anaesthesiology
影响因子:
--
作者:
[Kaye AD, Cornett EM, Brondeel KC, Lerner ZI, Knight HE, Erwin A, Charipova K, Gress KL, Urits I, Urman RD, Fox CJ, Kevil CG]
通讯作者:
Kevil CG
DOI:
10.1038/s41398-022-01837-w
发表时间:
2022-02-22
期刊:
Translational psychiatry
影响因子:
6.8
作者:
[Nahar L, Kaufman SE, Davis PG, Saunders SL, Disbrow EA, Patterson JC, Nam HW]
通讯作者:
Nam HW
共 39 条
Administrative Core
-
批准号:10715403
-
项目类别:
-
资助金额:$43.8万
-
财政年份:2023
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10630127
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10206260
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10427218
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
CSE regulation of vascular remodeling
-
批准号:10007007
-
项目类别:
-
资助金额:$42.8万
-
财政年份:2020
-
负责人:Christopher G Kevil
-
依托单位:
SARS-CoV-2 Genomic Surveillance in North Louisiana
-
批准号:10595390
-
项目类别:
-
资助金额:$73.0万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Administration and Mentorship Core
-
批准号:10331748
-
项目类别:
-
资助金额:$39.28万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Center for Redox Biology and Cardiovascular Disease
-
批准号:9763036
-
项目类别:
-
资助金额:$26.34万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
SARS-CoV-2 Genomic Surveillance in North Louisiana
-
批准号:10381353
-
项目类别:
-
资助金额:$73.0万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Center for Redox Biology and Cardiovascular Disease
-
批准号:10331747
-
项目类别:
-
资助金额:$208.74万
-
财政年份:2018
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
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批准号:8463031
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项目类别:
-
资助金额:$34.27万
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财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
-
批准号:8656802
-
项目类别:
-
资助金额:$35.28万
-
财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
Hydrogen sulfide and vascular remodeling
-
批准号:8274176
-
项目类别:
-
资助金额:$36.0万
-
财政年份:2012
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7471450
-
项目类别:
-
资助金额:$35.11万
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财政年份:2006
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负责人:Christopher G Kevil
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依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
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批准号:7662263
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项目类别:
-
资助金额:$34.81万
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财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
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批准号:7143265
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项目类别:
-
资助金额:$36.25万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7899834
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项目类别:
-
资助金额:$34.81万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ICAM-1 governs angiogenesis and endothelial redox status
-
批准号:7266184
-
项目类别:
-
资助金额:$35.2万
-
财政年份:2006
-
负责人:Christopher G Kevil
-
依托单位:
ROLE OF MAC-1/ICAM-1 INTERACTIONS IN VASCULITIS
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批准号:6530601
-
项目类别:
-
资助金额:$1.29万
-
财政年份:2002
-
负责人:Christopher G Kevil
-
依托单位:
ROLE OF MAC-1/ICAM-1 INTERACTIONS IN VASCULITIS
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批准号:6363477
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项目类别:
-
资助金额:$4.02万
-
财政年份:2001
-
负责人:Christopher G Kevil
-
依托单位:
海外基金