SARS-CoV-2 Genomic Surveillance in North Louisiana

路易斯安那州北部的 SARS-CoV-2 基因组监测

• 批准号: 10595390
• 负责人: Christopher G Kevil
• 金额: $ 73万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595390
• 关键词: 2019-nCoV; Agreement; Arkansas; Biologic Characteristic; Biology; COVID-19; COVID-19 pandemic; COVID-19 patient; COVID-19 surveillance; COVID-19 testing; COVID-19 vaccine; Cardiology; Cardiopulmonary; Cardiovascular Diseases; Cells; Centers for Disease Control and Prevention (U.S.); Clinical Research; Collaborations; Communication; Communities; Community Health; Contracts; Critical Care; Data; Disease; Disease Outbreaks; Dose; Economics; Evolution; Exhibits; FDA approved; Faculty; First Independent Research Support and Transition Awards; Foundations; Funding; Genomics; Health; Health care facility; Hospitals; Humoral Immunities; Immunology; Individual; Infection; Infrastructure; Laboratories; Louisiana; Mass Vaccinations; Mutation; Outcome; Oxidation-Reduction; Pathogenesis; Pathogenicity; Pathologic Processes; Patients; Personal Satisfaction; Persons; Positioning Attribute; Public Health; Publishing; Quantitative Reverse Transcriptase PCR; Research; Risk Factors; Role; SARS-CoV-2 B.1.1.7; SARS-CoV-2 genome; SARS-CoV-2 infection; SARS-CoV-2 positive; SARS-CoV-2 variant; Site; Specimen; Testing; Texas; Translations; Tropism; United States; United States National Institutes of Health; Vaccinated; Vaccination; Vaccinee; Vaccines; Variant; Viral; Viral Genome; Virus; Work; data sharing; experience; genome sequencing; novel; pandemic disease; programs; response; severe COVID-19; social; success; surveillance data; testing services; transmission process; vaccine evaluation; variants of concern; viral genomics; vulnerable community

ABSTRACT Viral genomic surveillance is critical for identification of SARS-CoV-2 variants that exhibit biological characteristics of concern for public health, such as escape from humoral immunity, enhanced transmissibility, and/or increased pathogenic potential. This competitive revision proposal represents a collaboration between two LSU Health Shreveport (LSUHS) CoBRE’s (Center for Redox Biology and Cardiovascular Disease [CRBCD] and Center for Applied Immunology and Pathological Processes [CAIPP]) and leverages established institutional programs including the Center for Emerging Viral Threats’ (CEVT) CLIA/CAP certified reference laboratory, ongoing COVID-19 clinical research, community mass vaccination and testing services, and a highly productive viral genome sequencing program that have served North and Central Louisiana throughout the pandemic. Additionally, LSUHS is in active partner with the Louisiana Department of Health (LDH) for these efforts and has a strong foundation for translation of viral genomic surveillance data into favorable public health outcomes, such as protection of vulnerable communities and targeted mitigation steps against variants of concern. As such, this competitive revision supplement will pursue the following two specific aims: Aim 1) Establish rapid SARS-CoV- 2 viral genome sequencing and data sharing prioritized by re-infections and infections of vaccine recipients; and Aim 2) Perform SARS-CoV-2 viral genome sequencing and data sharing of moderate to severe COVID-19 patients with predisposing risk factors and/or cardiopulmonary complications. Together, this work will greatly enhance genomic surveillance of SARS-CoV-2 in Louisiana, East Texas, and Southern Arkansas to benefit US public health and advance research regarding this devastating virus.

抽象的 病毒基因组监测对于鉴定暴露于生物学的SARS-COV-2变体至关重要 关注公共卫生的特征，例如逃避体液免疫力，增强的传播性， 和/或致病潜力增加。该竞争性修订建议代表了 两个LSU Health Shreveport（LSUHS）COBRE（氧化还原生物学和心血管疾病中心[CRBCD] 和应用免疫学和病理过程中心[CAIPP]）和杠杆建立的机构 包括新兴病毒威胁中心（CEVT）CLIA/CAP认证参考实验室的计划， 持续的COVID-19临床研究，社区群众疫苗接种和测试服务以及高效的 病毒基因组测序计划在整个大流行中都为路易斯安那州北部和中部服务。 此外，LSUHS与路易斯安那州卫生部（LDH）一起积极合作，并有 将病毒基因组监测数据转化为有利的公共卫生结果的强大基础 作为保护脆弱社区的保护，并针对令人关注的变体采取了缓解步骤。因此，这个 竞争性修订补充剂将追求以下两个具体目标：目标1）建立快速的SARS-COV- 2病毒基因组测序和数据共享通过重新感染和疫苗感染优先 接收者；目标2）执行SARS-COV-2病毒基因组测序和中度数据共享 严重的Covid-19患者患有易感性风险因素和/或心肺并发症的患者。 这项工作将大大增强对路易斯安那州，东德克萨斯州和德克萨斯州SARS-COV-2的基因组监视 阿肯色州南部有益于美国的公共卫生，并就这种毁灭性病毒进行研究。