SARS-CoV-2 Genomic Surveillance in North Louisiana

路易斯安那州北部的 SARS-CoV-2 基因组监测

• 批准号: 10595390
• 负责人: Christopher G Kevil
• 金额: $ 73万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595390
• 关键词: 2019-nCoV; Agreement; Arkansas; Biologic Characteristic; Biology; COVID-19; COVID-19 pandemic; COVID-19 patient; COVID-19 surveillance; COVID-19 testing; COVID-19 vaccine; Cardiology; Cardiopulmonary; Cardiovascular Diseases; Cells; Centers for Disease Control and Prevention (U.S.); Clinical Research; Collaborations; Communication; Communities; Community Health; Contracts; Critical Care; Data; Disease; Disease Outbreaks; Dose; Economics; Evolution; Exhibits; FDA approved; Faculty; First Independent Research Support and Transition Awards; Foundations; Funding; Genomics; Health; Health care facility; Hospitals; Humoral Immunities; Immunology; Individual; Infection; Infrastructure; Laboratories; Louisiana; Mass Vaccinations; Mutation; Outcome; Oxidation-Reduction; Pathogenesis; Pathogenicity; Pathologic Processes; Patients; Personal Satisfaction; Persons; Positioning Attribute; Public Health; Publishing; Quantitative Reverse Transcriptase PCR; Research; Risk Factors; Role; SARS-CoV-2 B.1.1.7; SARS-CoV-2 genome; SARS-CoV-2 infection; SARS-CoV-2 positive; SARS-CoV-2 variant; Site; Specimen; Testing; Texas; Translations; Tropism; United States; United States National Institutes of Health; Vaccinated; Vaccination; Vaccinee; Vaccines; Variant; Viral; Viral Genome; Virus; Work; data sharing; experience; genome sequencing; novel; pandemic disease; programs; response; severe COVID-19; social; success; surveillance data; testing services; transmission process; vaccine evaluation; variants of concern; viral genomics; vulnerable community

ABSTRACT Viral genomic surveillance is critical for identification of SARS-CoV-2 variants that exhibit biological characteristics of concern for public health, such as escape from humoral immunity, enhanced transmissibility, and/or increased pathogenic potential. This competitive revision proposal represents a collaboration between two LSU Health Shreveport (LSUHS) CoBRE’s (Center for Redox Biology and Cardiovascular Disease [CRBCD] and Center for Applied Immunology and Pathological Processes [CAIPP]) and leverages established institutional programs including the Center for Emerging Viral Threats’ (CEVT) CLIA/CAP certified reference laboratory, ongoing COVID-19 clinical research, community mass vaccination and testing services, and a highly productive viral genome sequencing program that have served North and Central Louisiana throughout the pandemic. Additionally, LSUHS is in active partner with the Louisiana Department of Health (LDH) for these efforts and has a strong foundation for translation of viral genomic surveillance data into favorable public health outcomes, such as protection of vulnerable communities and targeted mitigation steps against variants of concern. As such, this competitive revision supplement will pursue the following two specific aims: Aim 1) Establish rapid SARS-CoV- 2 viral genome sequencing and data sharing prioritized by re-infections and infections of vaccine recipients; and Aim 2) Perform SARS-CoV-2 viral genome sequencing and data sharing of moderate to severe COVID-19 patients with predisposing risk factors and/or cardiopulmonary complications. Together, this work will greatly enhance genomic surveillance of SARS-CoV-2 in Louisiana, East Texas, and Southern Arkansas to benefit US public health and advance research regarding this devastating virus.

抽象的 病毒基因组监测对于识别具有生物学特征的 SARS-CoV-2 变体至关重要 关注公共卫生的特征，例如逃避体液免疫、增强的传播性、 和/或致病潜力增加。这项具有竞争力的修订提案代表了双方之间的合作 两个路易斯安那州立大学什里夫波特健康中心 (LSUHS) CoBRE（氧化还原生物学和心血管疾病中心 [CRBCD] 和应用免疫学和病理过程中心 [CAIPP]）并利用现有的机构 计划包括新兴病毒威胁中心 (CEVT) CLIA/CAP 认证参考实验室， 正在进行的 COVID-19 临床研究、社区大规模疫苗接种和检测服务以及高效的 病毒基因组测序计划在整个大流行期间为路易斯安那州北部和中部提供服务。 此外，路易斯安那州立大学医学部 (LSUHS) 与路易斯安那州卫生部 (LDH) 积极合作开展这些工作，并已 为将病毒基因组监测数据转化为有利的公共卫生结果奠定了坚实的基础，例如 作为保护弱势社区和针对所关注的变种采取有针对性的缓解措施。因此，这 竞争性修订补充文件将追求以下两个具体目标： 目标 1) 建立快速 SARS-CoV- 2 以再次感染和疫苗感染为优先的病毒基因组测序和数据共享 收件人；目标 2) 进行 SARS-CoV-2 病毒基因组测序和数据共享 具有诱发危险因素和/或心肺并发症的重症 COVID-19 患者。 总之，这项工作将大大加强路易斯安那州、德克萨斯州东部和路易斯安那州对 SARS-CoV-2 的基因组监测。 南阿肯色州将造福美国公共卫生并推进有关这种毁灭性病毒的研究。