Cortical Underpinnings of Gait and Falls in Aging: A Novel Brain-Body Imaging Approach

步态的皮质基础和衰老过程中的跌倒：一种新颖的脑体成像方法

• 批准号: 10381863
• 负责人: Pierfilippo De Sanctis
• 金额: $ 11.68万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381863
• 关键词: Accounting; Address; Adult; Age; Aging; Animals; Anterior; Attention; Basal Ganglia; Behavioral; Biological; Biomedical Engineering; Biometry; Brain; Cessation of life; Cities; Clinical; Clinical Research; Cognition; Cognitive; Communities; Complement; Data; Development; Development Plans; Early identification; Elderly; Electroencephalography; Electrophysiology (science); Epidemiology; Event-Related Potentials; Evoked Potentials; Exposure to; Fall prevention; Fostering; Functional disorder; Funding; Future; Gait; Gait speed; Geriatrics; Goals; Grant; Human; Impairment; Incidence; Individual; Injury; Institutes; Institutionalization; Instruction; Intervention; Investigation; Knowledge; Laboratories; Lead; Leadership; Limb structure; Link; Longitudinal Studies; Maps; Medicine; Mentored Research Scientist Development Award; Mentors; Motor; Muscle; Neuraxis; Neurology; Neurons; New York; Participant; Pattern; Pediatrics; Performance; Periodicity; Phase; Play; Prevention; Process; Quality of life; Research; Research Assistant; Research Design; Research Ethics; Research Methodology; Research Project Grants; Research Proposals; Resources; Risk Assessment; Risk Factors; Role; Series; Signal Transduction; Sorting - Cell Movement; Standardization; Task Performances; Techniques; Technology; Telephone; Time; Training; Training Programs; Translational Research; Walking; Writing; adverse outcome; age related; aged; aging brain; base; career; career development; cognitive ability; cognitive neuroscience; college; computational neuroscience; design; epidemiology study; executive function; experience; fall risk; falls; foot; force sensor; frontal lobe; high risk; human old age (65+); imaging approach; imaging system; improved; improved mobility; innovation; insight; kinematics; longitudinal design; neuroimaging; neuromechanism; neurophysiology; new technology; novel; preventive intervention; professor; programs; public health relevance; relating to nervous system; response; signal processing; skills; translational scientist; treadmill; young adult

PROJECT SUMMARY The Candidate is a Research Assistant Professor in the Department of Neurology and Pediatrics at the Albert Einstein College of Medicine. The proposed K01 Mentored Research Scientist Development Award will foster the Candidate’s development as an independent translational researcher in the study of mobility decline in aging with a focus on cortical contributions. The overall goal of the proposed application is to provide the Candidate with training in advanced biomedical signal processing for integrated analysis of kinematic and EEG neurophysiological recordings during walking, to provide clinical exposure to geriatric and mobility assessment, and the design of longitudinal studies to help him achieve his long-term career goal of establishing independence as a translational researcher in the neuro-epidemiologyof mobility decline in aging. The Career Development Plan builds on the Candidate’s expertise in cognitive neuroscience of aging, obtained through prior training in behavioral and EEG electrophysiological assessment of age-related changes in cognitive and motor functions. A rigorous training plan is proposed, emphasizing formal instruction and hands-on clinical and research experience in biomedical signal processing, fall risk assessment, epidemiology, biostatistics, grant writing and research ethics. Training in advanced biomedical signal processing to determine kinematic-EEG signals during walking will be obtained through courses and one-on- one tutorials offered by the Cognitive Neurophysiology Laboratory at Einstein, the Biomedical Engineering Department at the City College of New York, MathWorksTM, and the Swartz Center for Computational Neuroscience in San Diego. Clinical exposure to geriatric and mobility assessment will be obtained through the Center for the Aging Brain and ongoing mobility investigations at the Cognitive & Motor Aging Lab. Training in epidemiological study design, biostatistics and research ethics will be obtained through the Clinical Research Training Program offered by the Einstein-Montefiore Institute for Clinical and Translational Research. A series of supplemental enrichment activities will complement didactic training and enhance the Candidate’s academic leadership skills. The accompanying mentored research project proposes a combined cross-sectional and longitudinal investigation to determine contributions of the central nervous system to age-related decline in moblitiy. The research proposal focuses on developing targeted applications of a novel EEG-based technique - Mobile Brain-BodyImaging (MOBI) during active walking to examine the link between gait, cognition and falls in aging. The Candidate will benefit from the combined resources on two funded Program Projects at Einstein: the Biological and Neural Mechanism of Fall (PI: J. Verghese) and the Central Control of Mobility In Aging (PI: R. Holtzer). At the institutional level, the Candidate has access to a diverse array of CTSA-sponsored Core resources such as Biostatistics and Study Design. Completion of the activities outlined in this KO1 application will provide clinical training and mentored research experiences that will prepare the Candidate to achieve his long-term goal of conducting innovative translational research to enhance cortical- based prevention and intervention to improve mobility and quality of life in older adults.

项目摘要 候选人是阿尔伯特大学神经病学和儿科系的研究助理教授。 爱因斯坦医学院。拟议的K 01指导研究科学家发展奖将促进 候选人的发展作为一个独立的翻译研究人员在流动性下降的研究， 衰老与大脑皮层的作用有关建议的应用程序的总体目标是提供 候选人在先进的生物医学信号处理的培训，以综合分析运动 和EEG神经生理学记录，为老年人和 流动性评估和纵向研究的设计，以帮助他实现他的长期职业生涯 目标是作为一名移动性神经流行病学的翻译研究者建立独立性 衰老的下降。职业发展计划建立在候选人在认知神经科学方面的专业知识基础上 的老化，通过事先培训获得的行为和脑电图电生理评估与年龄有关的 认知和运动功能的变化。提出了严格的培训计划，强调正式指导 在生物医学信号处理，跌倒风险评估， 流行病学、生物统计学、赠款写作和研究道德。高级生物医学信号培训 处理，以确定行走过程中的运动脑电图信号将获得通过课程和一对一， 一个教程提供的认知神经生理学实验室在爱因斯坦，生物医学工程 纽约城市学院数学系和斯沃茨计算中心 神经科学在圣地亚哥。老年人的临床暴露和活动能力评估将通过 大脑老化中心和认知与运动老化实验室正在进行的移动性调查。培训 流行病学研究设计、生物统计学和研究伦理学将通过临床研究获得 由Einstein-Montefiore临床和转化研究所提供的培训计划。一系列 的补充充实活动将补充教学培训，提高候选人的学术 领导能力伴随的指导研究项目提出了一个综合的横截面 和纵向调查，以确定中枢神经系统对年龄相关的 流动性下降。该研究计划的重点是开发一种新的基于EEG的有针对性的应用程序。 技术-主动行走期间的移动的脑-体成像（MOBI），以检查步态， 认知和福尔斯衰老。候选人将受益于两个资助计划的综合资源 项目在爱因斯坦：跌倒的生物和神经机制（PI：J. Verghese）和中央控制 老年人的流动性（PI：R。Holtzer）。在机构一级，候选人可以获得各种各样的 CTSA赞助的核心资源，如生物统计学和研究设计。完成概述的活动 在此KO 1应用程序将提供临床培训和指导的研究经验，将准备 候选人，以实现他的长期目标，进行创新的转化研究，以提高皮层- 基于预防和干预，以改善老年人的流动性和生活质量。