Unplanned Early Readmissions of Hospitalized Patients with Cirrhosis
住院肝硬化患者的意外提前再入院
基本信息
- 批准号:10384144
- 负责人:
- 金额:$ 9.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-15 至 2022-02-28
- 项目状态:已结题
- 来源:
- 关键词:Active LearningAscitesAwardBehavioralBiometryCaregiver BurdenCaringCharacteristicsCirrhosisClinical ResearchClinical SciencesClinical TrialsCognitiveConsensusDataData AnalysesDevelopment PlansDiseaseEligibility DeterminationEnrollmentEnvironmentExtramural ActivitiesFosteringFundingFutureGastrointestinal HemorrhageGoalsGrowth and Development functionHealthHealth Care Quality IndicatorsHealth PrioritiesHealth Services ResearchHealthcare SystemsHepatic EncephalopathyHepatologyHospice CareHospitalizationHospitalsIncidenceIndianaInfectionInformation NetworksInstitutesInterventionIntervention StudiesLeadLiver CirrhosisLiver diseasesMentorsMentorshipMethodologyMethodsModelingOutcomePalliative CarePatientsPhysiciansPopulationPositioning AttributeProcessProspective cohortProspective cohort studyPsychologyPublic HealthQualitative ResearchResearchResearch PersonnelResourcesRisk FactorsScientistSenior ScientistSeverity of illnessSocial WorkSpecialistStructureTranslational ResearchTransplantationTransplantation SurgeryUniversitiesValidationcare outcomescareercareer developmentcostcost estimatedesigneffective interventionend stage diseasefollow-uphigh riskhigh risk populationhospice environmenthospital readmissionimplementation scienceimprovedinnovationliver transplantationmodifiable riskmortalitymulti-component interventionmultidisciplinarypatient orientedpatient oriented researchpatient stratificationpredictive modelingprogramsprospectiveresearch and developmentrisk stratificationskillssocial factorstime use
项目摘要
PROJECT SUMMARY
Patients with liver cirrhosis who are discharged from the hospital have high rates of early hospital readmission,
and these readmissions are a significant burden to the health care system. Reducing readmissions is a priority
for the health care system, but requires a thorough understanding of modifiable risk factors leading to
readmission. In addition, many patients who are readmitted to the hospital may benefit from hospice referral,
which is underutilized in patients with cirrhosis, and which may also reduce readmissions. This proposal
describes a career development plan that will enable the candidate to develop expertise in patient-oriented
clinical research by acquiring the necessary skills in health services research, implementation science,
palliative care, and biostatistics. The specific aims are to (1) determine the incidence and predictors of
unplanned 30 day readmissions in patients with cirrhosis; (2) identify factors associated with preventable
unplanned 30 day readmissions; and (3) develop criteria that identify hospitalized patients with cirrhosis who
are suitable for hospice care. To achieve these aims, the candidate will (1) study detailed multidimensional
characteristics of a large prospective cohort of hospitalized patients with cirrhosis; (2) systematically assess
readmission preventability; and (3) convene an expert panel using the modified Delphi consensus process to
identify criteria for hospice eligibility.
The proposed career development plan integrates: close mentoring from a multidisciplinary team of senior
scientists; advanced coursework in health services research, biostatistics, implementation science, and
qualitative research; experiential learning through the conduct of the proposed research plan; and a highly
supportive research environment. The mentorship team, which includes independent investigators with
expertise in clinical and translational research in hepatology (Chalasani), health services research and
implementation science (Boustani), palliative care and consensus methodology (Sachs), and observational and
longitudinal data analysis and biostatistics (Gao), will guide the candidate's research and career development.
The research environment at Indiana University includes multidisciplinary collaborative organizations such as
the Indiana Clinical and Translational Sciences Institute and the Center for Health Innovation and
Implementation Science, which will help foster the candidate's professional growth and career development. At
the conclusion of this program, the candidate will be well positioned to become an independent physician-
scientist conducting high quality health services research in cirrhosis.
项目摘要
肝硬化患者出院后早期再入院率高,
并且这些再入院对卫生保健系统来说是一个重大负担。减少再入院是当务之急
但需要彻底了解可改变的风险因素,
再入院此外,许多再次入院的患者可能会从临终关怀转诊中受益,
其在肝硬化患者中未被充分利用,并且其也可以减少再入院。这项建议
描述了职业发展计划,使候选人能够发展以患者为导向的专业知识
临床研究,通过获得必要的技能,在卫生服务研究,实施科学,
姑息治疗和生物统计学具体目标是(1)确定以下疾病的发生率和预测因素:
肝硬化患者计划外30天再入院;(2)确定与可预防的
计划外30天再入院;(3)制定标准,确定肝硬化住院患者,
适合临终关怀。为了实现这些目标,候选人将(1)研究详细的多维
肝硬化住院患者大型前瞻性队列的特征;(2)系统评估
再入院可预防性;(3)使用修改后的德尔菲共识流程召集专家小组,
确定临终关怀资格标准。
拟议的职业发展计划包括:
科学家;在卫生服务研究,生物统计学,实施科学,和
质的研究;通过拟议的研究计划进行体验式学习;以及高度
支持性研究环境。指导小组,其中包括独立调查员,
肝病学(Chalasani)临床和转化研究的专业知识,卫生服务研究和
实施科学(Boustani)、姑息治疗和共识方法论(Sachs)以及观察和
纵向数据分析和生物统计学(高),将指导候选人的研究和职业发展。
印第安纳州大学的研究环境包括多学科协作组织,如
印第安纳州临床和转化科学研究所和健康创新中心,
实施科学,这将有助于促进候选人的专业成长和职业发展。在
该计划的结论,候选人将很好地定位成为一个独立的医生-
科学家在肝硬化中进行高质量的卫生服务研究。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Features of Blood Clotting on Thromboelastography in Hospitalized Patients With Cirrhosis.
- DOI:10.1016/j.amjmed.2020.04.029
- 发表时间:2020-12
- 期刊:
- 影响因子:0
- 作者:Shamseddeen H;Patidar KR;Ghabril M;Desai AP;Nephew L;Kuehl S;Chalasani N;Orman ES
- 通讯作者:Orman ES
Spontaneous Fluctuations in Liver Biochemistries in Patients with Compensated NASH Cirrhosis: Implications for Drug Hepatotoxicity Monitoring.
代偿性 NASH 肝硬化患者肝脏生化的自发波动:对药物肝毒性监测的影响。
- DOI:10.1007/s40264-019-00896-1
- 发表时间:2020
- 期刊:
- 影响因子:4.2
- 作者:Shamseddeen,Hani;Vilar-Gomez,Eduardo;Chalasani,Naga;Myers,RobertP;Subramanian,GMani;Shlevin,HaroldH;Allgood,AdamE;Orman,EricS
- 通讯作者:Orman,EricS
Incidence and Risk Factors of Recurrent Clostridioides difficile Infection in Patients With Cirrhosis.
肝硬化患者复发艰难梭菌感染的发病率和危险因素。
- DOI:10.14309/ctg.0000000000000189
- 发表时间:2020
- 期刊:
- 影响因子:3.6
- 作者:Phatharacharukul,Parkpoom;Purpura,RussellD;Gandhi,Devika;Xu,Huiping;Bickett-Burkhart,Katie;Chalasani,Naga;Fischer,Monika;Orman,EricS
- 通讯作者:Orman,EricS
Improving Outcomes of Bariatric Surgery in Patients With Cirrhosis in the United States: A Nationwide Assessment.
- DOI:10.14309/ajg.0000000000000911
- 发表时间:2020-11
- 期刊:
- 影响因子:0
- 作者:Are VS;Knapp SM;Banerjee A;Shamseddeen H;Ghabril M;Orman E;Patidar KR;Chalasani N;Desai AP
- 通讯作者:Desai AP
Hospital Readmissions in Patients with Cirrhosis: A Systematic Review.
- DOI:10.12788/jhm.2967
- 发表时间:2018-07
- 期刊:
- 影响因子:2.6
- 作者:Orman ES;Ghabril M;Emmett TW;Chalasani N
- 通讯作者:Chalasani N
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Eric Orman其他文献
Eric Orman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Eric Orman', 18)}}的其他基金
The Transitional Liver Clinic (TLC): Reducing Liver Disease Readmission
过渡肝脏诊所 (TLC):减少肝病再入院
- 批准号:
10587530 - 财政年份:2023
- 资助金额:
$ 9.01万 - 项目类别:
The Cirrhosis Medical Home: A Feasibility Study
肝硬化医疗之家:可行性研究
- 批准号:
10202587 - 财政年份:2020
- 资助金额:
$ 9.01万 - 项目类别:
Unplanned Early Readmissions of Hospitalized Patients with Cirrhosis
住院肝硬化患者的意外提前再入院
- 批准号:
9353422 - 财政年份:2016
- 资助金额:
$ 9.01万 - 项目类别:
Unplanned Early Readmissions of Hospitalized Patients with Cirrhosis
住院肝硬化患者的意外提前再入院
- 批准号:
9767124 - 财政年份:2016
- 资助金额:
$ 9.01万 - 项目类别:
相似海外基金
Analyses of immune response and bacteria in cirrhotic ascites with Tm mapping method.
Tm 图谱法分析肝硬化腹水中的免疫反应和细菌。
- 批准号:
20K08305 - 财政年份:2020
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Randomized controlled trial to elucidate "would patients be weakened if ascites removed?"
随机对照试验阐明“如果腹水被清除,患者会变得虚弱吗?”
- 批准号:
20K16567 - 财政年份:2020
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Development of new immuno-cell therapy for the treatment of refractory malignant ascites and pleural effusion
开发新的免疫细胞疗法治疗难治性恶性腹水和胸腔积液
- 批准号:
19K09196 - 财政年份:2019
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ascites proteomics reveal the mechanism of pancreatic cancer peritoneal dissemination
腹水蛋白质组学揭示胰腺癌腹膜播散机制
- 批准号:
19K18107 - 财政年份:2019
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
A Novel Therapy for gastrointestinal cancer targeting exosome in malignant ascites
一种针对恶性腹水中外泌体的胃肠癌新疗法
- 批准号:
18H02882 - 财政年份:2018
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Peritoneal metastasis Prediction by exosome in washing ascites for gastric cancer
胃癌洗腹水中外泌体预测腹膜转移
- 批准号:
18K16321 - 财政年份:2018
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Label-free microfluidic enrichment of cancer cells from noncancer cells in ascites fluid
无标记微流体从腹水中的非癌细胞中富集癌细胞
- 批准号:
9251748 - 财政年份:2016
- 资助金额:
$ 9.01万 - 项目类别:
Preparation of ascites purification device for cancerous ascites and establishment of portable continuous ascites purification perfusion method
癌性腹水腹水净化装置的研制及便携式连续腹水净化灌注方法的建立
- 批准号:
16K01425 - 财政年份:2016
- 资助金额:
$ 9.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Label-free microfluidic enrichment of cancer cells from noncancer cells in ascites fluid
无标记微流体从腹水中的非癌细胞中富集癌细胞
- 批准号:
9036692 - 财政年份:2016
- 资助金额:
$ 9.01万 - 项目类别:
Identifying Factors in Malignant Ascites Facilitating Gastric Adenocarcinoma Peritoneal Metastasis
确定恶性腹水促进胃腺癌腹膜转移的因素
- 批准号:
349961 - 财政年份:2015
- 资助金额:
$ 9.01万 - 项目类别:
Studentship Programs