Methods for Selective Organic Synthesis based on Ionic Catalysts

基于离子催化剂的选择性有机合成方法 项目摘要 该研究计划的主要目标是开发基于以下的催化对映选择性转化： 过渡金属和手性阴离子催化剂，将广泛适用于制备治疗 相关的有机分子为此，新的碳-碳π-键的对映选择性反应是 的建议，重点放在对映选择性sp3-C-F键的建设发展。 另外，产生或使用可用的结构单元如烯烃和硼酸的反应将 成为目标。这些方法将用于氟化结构单元的对映选择性构建， 杂环和天然产物类似物。因此，我们预计，拟议的空气和水分耐受 转换将为合成化学家和生物医学研究人员提供分子生物学的额外工具。 合成和用于单一对映体构建。

Methods for Selective Organic Synthesis based on Ionic Catalysts Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new enantioselective reactions of carbon-carbon π-bonds are proposed, with a major emphasis placed on the development of enantioselective sp3-C-F bond construction. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will be exploited in the enantioselective construction of fluorinated building blocks, heterocycles and natural product analogs. Thus, we anticipate that the proposed air and moisture tolerant transformations will provide synthetic chemists and biomedical researchers with additional tools for molecular synthesis and for single enantiomer construction.