Methods for Selective Organic Synthesis based on Ionic Catalysts

基于离子催化剂的选择性有机合成方法

• 批准号: 10386162
• 负责人: F. Dean Toste
• 金额: $ 2.1万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-03 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10386162
• 关键词: Air; Alkenes; Anions; Boronic Acids; Carbon; Catalysis; Chemistry; Development; Equipment; Fluorine; Funding; Goals; Methods; Molecular; Natural Products; Nuclear Magnetic Resonance; Organic Synthesis; Parents; Preparation; Reaction; Research; Research Personnel; Therapeutic; Transition Elements; Work; analog; base; catalyst; enantiomer; improved; instrumentation; parent project; pi bond; preservation; programs; tool

Methods for Selective Organic Synthesis based on Ionic Catalysts Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new enantioselective reactions of carbon-carbon π-bonds are proposed, with a major emphasis placed on the development of enantioselective sp3-C-F bond construction. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will be exploited in the enantioselective construction of fluorinated building blocks, heterocycles and natural product analogs. Thus, we anticipate that the proposed air and moisture tolerant transformations will provide synthetic chemists and biomedical researchers with additional tools for molecular synthesis and for single enantiomer construction.

基于离子催化剂的选择性有机合成方法 项目摘要 本研究计划的主要目标是开发基于以下物质的催化对映体选择性转化 具有广泛应用前景的过渡金属和手性阴离子催化剂 相关的有机分子。为此，碳-碳π-键的新的对映选择性反应是 重点介绍了对映体选择性SP3-C-F键结构的发展。 此外，生成或使用可用构件的反应，如烯烃和硼酸，将 成为靶子。这些方法将被用于对映体选择性地构建氟化构筑块， 杂环和天然产物类似物。因此，我们预计拟议的空气和湿度容忍度 转化将为合成化学家和生物医学研究人员提供更多的分子研究工具 合成并用于单一对映体的构建。