Methods for Selective Organic Synthesis based on Ionic Catalysts
Methods for Selective Organic Synthesis based on Ionic Catalysts
批准号:
9926044
负责人:
F. Dean Toste
金额:
$5.13万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-06-03 至 2021-05-31
中文摘要
项目摘要
这一研究计划的主要目标是开发新型催化对映体。
变换是基于金属离子的过渡和手性阴离子的催化,这一点将不会得到广泛的应用。
适用于治疗相关的有机药物分子的制备技术。朝着这一方向发展。
最后,提出了碳-碳-π-键的新的对映选择性反应,并提出了一种新的对映选择性反应。
主要的重点放在了欧洲反选择债券SP3-C-F的未来发展前景上。
建筑。此外,还会产生反应,或者会使用可用的积木。
如烯烃和硼酸等,将不会有针对性。这些新方法将不会在未来得到充分利用。
对氟化硅砌块、杂环化合物和天然橡胶的选择性研究
产品可以类比。因此,我们可以预料到,新提出的空气质量和水分容忍度将是最高的。
这些转化还将为合成技术化学家和生物医学研究人员提供技术支持。
额外的技术工具可以用于分子药物的合成,也可以用于单一对映体的构建。
英文摘要
Project Summary
The major goal of this research program is to develop catalytic enantioselective
transformations based on transition metal and chiral anion catalysis that will be broadly
applicable to the preparation of therapeutically relevant organic molecules. Towards this
end, new enantioselective reactions of carbon-‐‑carbon π-‐‑bonds are proposed, with a
major emphasis placed on the development of enantioselective sp3-‐‑C-‐‑F bond
construction. Additionally, reactions that generate or employ available building blocks,
such as alkenes and boronic acids, will be targeted. These methods will be exploited in
the enantioselective construction of fluorinated building blocks, heterocycles and natural
product analogs. Thus, we anticipate that the proposed air and moisture tolerant
transformations will provide synthetic chemists and biomedical researchers with
additional tools for molecular synthesis and for single enantiomer construction.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Methods for Selective Organic Synthesis based on Ionic Catalysts
-
批准号:10386162
-
项目类别:
-
资助金额:$2.1万
-
财政年份:2016
-
负责人:F. Dean Toste
-
依托单位:
Methods for Selective Organic Synthesis based on Ionic Catalysts
-
批准号:10581216
-
项目类别:
-
资助金额:$25.0万
-
财政年份:2016
-
负责人:F. Dean Toste
-
依托单位:
Methods for Selective Organic Synthesis based on Ionic Catalysts
-
批准号:10413814
-
项目类别:
-
资助金额:$46.36万
-
财政年份:2016
-
负责人:F. Dean Toste
-
依托单位:
Methods for Selective Organic Synthesis based on Ionic Catalysts
-
批准号:10643835
-
项目类别:
-
资助金额:$60.92万
-
财政年份:2016
-
负责人:F. Dean Toste
-
依托单位:
Enantioselective Synthesis by Chiral Anion Phase Transfer Catalysis
-
批准号:8725697
-
项目类别:
-
资助金额:$28.3万
-
财政年份:2013
-
负责人:F. Dean Toste
-
依托单位:
Enantioselective Synthesis by Chiral Anion Phase Transfer Catalysis
-
批准号:8579783
-
项目类别:
-
资助金额:$28.35万
-
财政年份:2013
-
负责人:F. Dean Toste
-
依托单位:
Base-selective heavy atom labels for electron microscopy-based DNA sequencing
-
批准号:8520467
-
项目类别:
-
资助金额:$8.86万
-
财政年份:2010
-
负责人:F. Dean Toste
-
依托单位:
Base-selective heavy atom labels for electron microscopy-based DNA sequencing
-
批准号:8134491
-
项目类别:
-
资助金额:$21.76万
-
财政年份:2010
-
负责人:F. Dean Toste
-
依托单位:
Base-selective heavy atom labels for electron microscopy-based DNA sequencing
-
批准号:7979188
-
项目类别:
-
资助金额:$21.82万
-
财政年份:2010
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon Bond Formation
-
批准号:7930038
-
项目类别:
-
资助金额:$18.32万
-
财政年份:2009
-
负责人:F. Dean Toste
-
依托单位:
New Transition Metal Catalysts for Organic Reactions
-
批准号:7262397
-
项目类别:
-
资助金额:$26.99万
-
财政年份:2007
-
负责人:F. Dean Toste
-
依托单位:
New Transition Metal Catalysts for Organic Reactions
-
批准号:7382502
-
项目类别:
-
资助金额:$26.27万
-
财政年份:2007
-
负责人:F. Dean Toste
-
依托单位:
New Transition Metal Catalysts for Organic Reactions
-
批准号:7771766
-
项目类别:
-
资助金额:$33.22万
-
财政年份:2007
-
负责人:F. Dean Toste
-
依托单位:
New Transition Metal Catalysts for Organic Reactions
-
批准号:7575660
-
项目类别:
-
资助金额:$27.31万
-
财政年份:2007
-
负责人:F. Dean Toste
-
依托单位:
New Transition Metal Catalysts for Organic Reactions
-
批准号:7900111
-
项目类别:
-
资助金额:$5.12万
-
财政年份:2007
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon Bond Formation
-
批准号:7216910
-
项目类别:
-
资助金额:$24.72万
-
财政年份:2005
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon Bond Formation
-
批准号:7027099
-
项目类别:
-
资助金额:$25.45万
-
财政年份:2005
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon Bond Formation
-
批准号:6902064
-
项目类别:
-
资助金额:$24.19万
-
财政年份:2005
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation
-
批准号:8259420
-
项目类别:
-
资助金额:$33.86万
-
财政年份:2005
-
负责人:F. Dean Toste
-
依托单位:
Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation
-
批准号:8042723
-
项目类别:
-
资助金额:$33.86万
-
财政年份:2005
-
负责人:F. Dean Toste
-
依托单位:
海外基金