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Physical Activity in Pregnancy for Intergenerational Obesity Prevention

孕期体力活动预防代际肥胖

基本信息

批准号：
10386354
负责人：
Samantha F Ehrlich
金额：
$ 4.82万
依托单位：
UNIVERSITY OF TENNESSEE KNOXVILLE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-21 至 2022-06-30
项目状态：
已结题

项目摘要

PROJECT ABSTRACT To curb the continuing obesity epidemic, ‘upstream’ prevention efforts are desperately needed. To inform such prevention efforts, increased scientific knowledge of the mechanisms through which physical activity (PA) in pregnancy, a modifiable lifestyle factor, may impact body size and composition in infancy is required. This K01 will provide Dr. Samantha F. Ehrlich Ph.D., with the expertise needed to achieve her career goals of reducing obesity and diabetes in women and children by promoting and ultimately increasing participation in PA. The central hypothesis of this proposal is that increasing PA during pregnancy may mitigate the development of obesity in both the mother (i.e., through appropriate GWG) and child (i.e., through appropriate birthweight and reduced body fat at birth, and developmental programming for appropriate weight/fat mass gains in infancy). The specific aims are as follows. Aim 1: To estimate the effects of PA during pregnancy on infant growth from birth to 1 year of age using novel methods that permit causal inference to be drawn from observational data. Aim 2: To estimate the effects of PA regime during pregnancy (i.e., objectively measured PA in early and late pregnancy) on infant body composition (i.e., percent body fat) from birth to 1 year of age using novel methods that permit causal inference to be drawn from observational data with time-dependent confounding (i.e., measures of PA, diet, and fat mass in early and late pregnancy). Aim 3: To conduct a pilot feasibility randomized controlled trial among women with GDM comparing the effects of a behavioral PA intervention (i.e., walking/stepping in place) versus general wellness education on PA levels, maternal glycemic profile in the third trimester, and infant size and anthropometrics. This research will expand scientific knowledge of the potential role of PA during pregnancy in ‘upstream’ obesity prevention. Dr. Assiamira Ferrara MD, Ph.D., Senior Research Scientist and Chief of the Women’s and Children’s Health Section at the KPNC Division of Research, will be my Primary Mentor (obesity prevention). Co-mentors with complementary expertise include Drs. David Bassett, Jr. (objectively measured PA), Hollie A. Raynor (nutrition and behavioral aspects of obesity prevention), and Romain Neugebauer (causal inference-based methods of analysis); Dr. Kelley Pettee Gabriel (PA epidemiology) is a Consultant. The research, new training and professional developmental afforded by this award will ensure Dr. Ehrlich’s successful transition to research independence in the area of PA during pregnancy for intergenerational obesity and diabetes prevention.

项目摘要为了遏制持续的肥胖流行，迫切需要“上游”预防工作。通知这样的预防工作，增加科学知识的机制，通过身体活动（PA），怀孕是一种可改变的生活方式因素，可能会影响婴儿期的身体大小和组成。K01 将提供给萨曼莎·F博士埃利希博士，拥有实现职业目标所需的专业知识，肥胖和糖尿病的妇女和儿童，促进并最终增加参与PA。的这一建议的中心假设是，在怀孕期间增加PA可能会减轻发展，在母亲（即，通过适当的GWG）和儿童（即，通过适当的出生体重，出生时减少体脂肪，以及婴儿期适当体重/脂肪量增加的发育规划）。具体目标如下。目的1：评估妊娠期间PA对婴儿生长的影响，使用新的方法，允许从观察数据中得出因果关系推断。目的2：评估妊娠期间PA方案的效果（即，在早期和晚期客观测量PA 怀孕）对婴儿身体组成的影响（即，从出生到1岁的体脂百分比）其允许从具有时间依赖性混杂的观测数据中得出因果推断（即，在怀孕早期和晚期测量PA、饮食和脂肪量）。目标3：进行试点可行性研究一项在妊娠期糖尿病妇女中比较行为PA干预效果的随机对照试验 (i.e.,步行/原地踏步）与一般健康教育对PA水平的影响，妊娠晚期，婴儿体型和人体测量学这项研究将扩大科学知识的怀孕期间PA在“上游”肥胖预防中的潜在作用。Assiamira费拉拉博士，医学博士，高级研究科学家兼KPNC妇女和儿童健康科科长，研究，将是我的主要导师（肥胖预防）。具有互补专业知识的共同导师包括 Drs.小大卫巴塞特（客观测量的PA），Hollie A.雷诺（肥胖的营养和行为方面预防），和罗曼Neugebauer（因果推理为基础的分析方法）;博士凯利佩蒂加布里埃尔 (PA流行病学）是一个顾问。研究，新的培训和专业发展提供了这一点该奖项将确保博士埃利希的成功过渡到研究的独立性，在该地区的PA期间怀孕是为了预防跨代肥胖和糖尿病。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Physical activity for blood glucose control in gestational diabetes mellitus: rationale and recommendations for translational behavioral interventions.

DOI：
10.1186/s40842-021-00120-z
发表时间：
2021-04-25
期刊：
Clinical diabetes and endocrinology
影响因子：
0
作者：
Onaade O;Maples JM;Rand B;Fortner KB;Zite NB;Ehrlich SF
通讯作者：
Ehrlich SF

Maternal Diabetes and Infant Sex Ratio.

DOI：
10.1007/s11892-021-01395-3
发表时间：
2021-06-10
期刊：
Current diabetes reports
影响因子：
4.2
作者：
Ehrlich SF
通讯作者：
Ehrlich SF

Diabetes risk status and physical activity in pregnancy: U.S. BRFSS 2011, 2013, 2015, 2017.

DOI：
10.1186/s12884-020-03434-5
发表时间：
2020-11-30
期刊：
BMC pregnancy and childbirth
影响因子：
3.1
作者：
Rand BG;Johnson TM;Ehrlich SF;Wideman L;Pivarnik JM;Richardson MR;Stone ML;Churilla JR
通讯作者：
Churilla JR

Using a consumer-based wearable activity tracker for physical activity goal setting and measuring steps in pregnant women with gestational diabetes mellitus: exploring acceptance and validity.