The RCMI Program in Health Disparities Research at Meharry Medical College (supplement)

梅哈里医学院的 RCMI 健康差异研究项目（补充）

• 批准号: 10382699
• 负责人: Samuel Evans Adunyah
• 金额: $ 50万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2022-09-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382699
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; African American; Area; Award; Basic Science; Behavioral Research; Bioinformatics; Biometry; Categories; Clinical Research; Collaborations; Communicable Diseases; Communities; Development; Disease; Down-Regulation; Environment; Equipment; Extramural Activities; Faculty; Floor; Fostering; Funding; Goals; Grant; HIV; HIV therapy; HIV-1; Health; Hospitals; Hypermethylation; Infectious Agent; Institution; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Mentorship; Methylation; MicroRNAs; Minor; Minority; Parents; Periodicity; Periodontal Diseases; Pilot Projects; Population; Progress Reports; Regulation; Research; Research Personnel; Research Priority; Research Project Grants; Role; Scientist; Services; Teacher Professional Development; Technology; Teleconferences; Tennessee; Testing; Translations; United States National Institutes of Health; Viral Proteins; base; biosafety level 2 facility; biosafety level 3 facility; career; chronic pain; ethnic difference; expectation; faculty research; health disparity; health disparity populations; improved; instrument; medical schools; microbiome; next generation; novel therapeutics; programs; promoter; racial difference; recruit; research facility; success

Abstract The RCMI Program in Health Disparities Research at Meharry Medical College proposed to support high quality basic, behavioral, and clinical research to eliminate health disparities through the following aims: 1. Support four outstanding research projects addressing HIV/AIDS, prostate cancer, racial and ethnic differences in periodontal disease microbiomes, and adversity-driven chronic pain to advance fundamental understanding of these health disparities. 2. Strengthen core technologies and expand bioinformatics and biostatistical services supporting the four research projects, as well as all Meharry research faculty, to increase institutional success in extramural funding studying diseases that disproportionally affect minority and other health disparity populations. 3. Nurture an environment conducive to developing new and early career investigators by facilitating a mentorship network, enhancing professional developmental activities, and providing pilot project funds. 4. Improve and expand relationships with community-based organizations that partner with Meharry. 5. Recruit outstanding magnet scientists to energize current faculty and contribute to our research capacity in cancers of the underserved, infectious diseases including HIV-AIDS, disparity-causing differences in microbiomes of minorities, and societal adversity leading to debilitating chronic pain in African Americans. The center received its first NIMHD U54 grant in September 2017 and the center is now in its fourth year of funding. Notably, HIV/AIDS research is one of our RCMI Center’s major research focuses. Dr. Chandravanu Dash is one of the full project investigators at our center and his project focuses on understanding the role of cellular miRNAs in HIV-1 replication. Secondly, he currently has an NIH R01 funded project on HIV/AIDS (R01 AI 136740). In addition, Meharry’s Center for HIV/AIDS Health Disparities Research has many other HIV investigators. The renovations and associated equipment requested in this application will significantly promote overall HIV/AIDS research at Meharry. The overall goal of this supplement aligns well with our RCMI center’s goal of addressing health disparities including HIV/AIDS. If this application is funded, the PI/PDs of our RCMI center will oversee this renovation to make sure it achieves its goals. Furthermore, Dr. Dash and other HIV research collaborators at Meharry will be required to participate in our RCMI center’s activities including faculty development, seminars, periodic work-in-progress presentations, monthly NIMHD/RCMI teleconference and submission of progress reports. In summary, funding of this supplement, will empower our RCMI center to expand its HIV research. Our overarching expectation is that the funding will enhance our overall ability and successes to address HIV/AIDS disparity in the population we serve as well as promote our HIV investigators’ competitiveness to obtain R01 grants to further boost HIV research at Meharry. .

摘要 Meharry医学院的RCMI健康差异研究计划建议支持高水平的 高质量的基础、行为和临床研究，通过以下目标消除健康差距： 1.支持四个杰出的研究项目，解决艾滋病毒/艾滋病，前列腺癌，种族和民族 牙周病微生物组的差异，以及逆境驱动的慢性疼痛， 了解这些健康差异。 2.强化核心技术，拓展生物信息学和生物统计学服务支撑四个 研究项目，以及所有梅哈里研究教师，以增加在校外资金机构的成功 研究对少数民族和其他健康不平等人群造成严重影响的疾病。 3.通过促进以下方式，营造有利于培养新的和早期职业调查员的环境： 导师网络，加强专业发展活动，并提供试点项目资金。 4.改善和扩大与Meharry合作的社区组织的关系。 5.招募优秀的磁铁科学家，以激励现有的教师，并为我们的研究作出贡献 能力不足的癌症，传染病，包括艾滋病毒-艾滋病， 少数民族的微生物组，以及导致非裔美国人衰弱的慢性疼痛的社会逆境。 该中心于2017年9月获得了第一笔NIMHD U 54赠款，该中心现已进入第四个年头 资金。值得注意的是，艾滋病毒/艾滋病研究是我们RCMI中心的主要研究重点之一。Chandravanu博士 Dash是我们中心的完整项目调查员之一，他的项目侧重于了解 HIV-1复制中的细胞miRNA。其次，他目前有一个NIH R 01资助的艾滋病毒/艾滋病项目（R 01 AI 136740）。此外，梅哈里的艾滋病毒/艾滋病健康差异研究中心还有许多其他艾滋病毒 investigators.本申请中要求的翻新和相关设备将大大促进 在Meharry的艾滋病研究。 这一补充的总体目标与我们的RCMI中心的目标，解决健康 包括艾滋病毒/艾滋病。如果此申请获得资助，我们RCMI中心的PI/PD将对此进行监督 以确保其实现其目标。此外，Dash博士和其他艾滋病毒研究合作者在 Meharry将被要求参加我们RCMI中心的活动，包括教师发展，研讨会， 定期进行工作进展情况介绍，每月举行国家排雷行动中心/区域协调员倡议电话会议，并提交进展情况 报道总而言之，该补充资金将使我们的RCMI中心能够扩大其艾滋病毒感染范围 research.我们的首要期望是这笔资金将增强我们的整体能力和成功 解决我们所服务的人群中艾滋病毒/艾滋病的差异，并促进我们的艾滋病毒调查人员 竞争力，以获得R 01赠款，以进一步推动艾滋病毒研究在梅哈里。 .