Probing the molecular interactions within carrier nanopores to enable model validation and deployment

探测载体纳米孔内的分子相互作用以实现模型验证和部署

• 批准号: 10061626
• 金额: $ 3.11万
• 依托单位: MESOX LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10061626
• 关键词: Probing; molecular; interactions; within; carrier

MESOX developed a novel particle carrier technology for enhancing the bioavailability of medicines. The carrier has nanopores within its structure and each nanopore behaves like a nano-container for drug molecules. When a drug is loaded within a nanopore, it converts to its amorphous solid form which easily dissolves in the patient body. As a result, drug efficacy could be enhanced due to better absorption, and lower doses would be required as opposed to the drug in its native state without our carrier.In line with the developed carrier, we have also built a molecular model of the carrier which allows us to screen drugs virtually on a computer prior to conducting laboratory experiments. This provides two key advantages to potential pharma and biotech customers:1- Saves their precious drug through avoiding extensive experimental formulation work.2- Provides quick feedback on the feasibility of our carrier technology for their drug molecule.However, a key to unlocking the power of this molecular model is to validate its observations using an advanced analytical technique. A technique is needed that can quantify the amount of drug within carrier (maximum amount that can be loaded), nature of drug loaded within carrier (molecular interactions, amorphous/crystalline phase) and preserves the carrier structure during the analysis process (for reliable results).The national physical laboratory will assist us with an advanced analytical technique that meets the above criteria for model validation.Our modelling capability once validated will represent a leap forward in formulation development science. It will help reduce the risks of the formulation process leading to lower product costs, and accelerate the timelines for the development of new medicines.Ultimately, this approach could lead to more lifesaving medicines getting into patients' hands quicker and saving the NHS and the UK taxpayer millions of pounds in healthcare costs.

MESOX开发了一种新的颗粒载体技术，以提高药物的生物利用度。载体的结构中有纳米孔，每个纳米孔的行为就像一个药物分子的纳米容器。当药物被装载到纳米孔中时，它会转化为无定形固体，很容易在患者体内溶解。因此，由于吸收更好，药物效率可以提高，与没有载体的药物天然状态相比，需要的剂量更低。与开发的载体一致，我们还建立了载体的分子模型，使我们能够在进行实验室实验之前，在计算机上虚拟地筛选药物。这为潜在的制药和生物技术客户提供了两个关键优势：1-通过避免大量的实验配方工作来节省他们的宝贵药物2-为他们的药物分子提供我们的载体技术的可行性的快速反馈。然而，解锁这种分子模型的力量的关键是使用先进的分析技术来验证其观察结果。需要一种技术来量化载体中的药物数量(最大可载药量)、载体中所负载药物的性质(分子相互作用、非晶相/晶相)，并在分析过程中保留载体结构(以获得可靠的结果)。国家物理实验室将为我们提供先进的分析技术，满足上述模型验证标准。我们的建模能力一旦得到验证，将代表着配方开发科学的飞跃。这将有助于降低配方过程中的风险，从而降低产品成本，并加快新药开发的时间表。最终，这种方法可能会导致更多挽救生命的药物更快地到达患者手中，并为NHS和英国纳税人节省数百万英镑的医疗成本。