Harnessing the microbial potential of fermented foods for healthy and sustainable food systems (DOMINO)

欧洲消费者表达了对更健康、更可持续的食品的明确需求。发酵食品具有满足这些期望的潜力，但需要科学地证明其对健康的影响，同时开发创新战略来解决可持续性和营养健康问题。在这个框架中，Domino将调查基于FF的饮食对健康人群和患有代谢综合征的队列的健康影响，以更好地关注健康生物标记物。我们将提供量身定制的微生物解决方案，使用综合的‘组学’战略和计算生物学模型，以应对与可持续食品生产和健康营养相关的挑战。在六个食品案例研究中，我们将让关键的利益相关者参与多行动者的方法，这些案例研究被选为植物性FF原型的广泛多样性的代表。这些目标将取得主要成果：表征牛奶开菲尔的健康影响；应用基于健康微生物组/人体生物标记物的诊断工具为患有代谢综合征的人提供基于FF的饮食建议；开发开放获取的数据库和新的计算工具，用于描述食品发酵过程中的代谢相互作用及其与健康肠道微生物组的重叠；提供研究和创新工作流程，以促进智能设计功能健康的微生物群、生物废物价格化、利用食品微生物群生物多样性的植物性案例研究的可持续进程；所有这些都得到关键利益攸关方和公民联合会的支持，包括通过几个活的劳动和量身定制的传播战略。我们将共同制定和迈向欧洲食品添加剂的未来愿景，同时通过他们的参与和真正整合他们的观点来增强公民对食品价值链的信任，为公民友好型创新铺平道路。

European consumers are expressing a clear demand for healthier and more sustainable food. Fermented foods (FFs) have the potential to meet these expectations but there is a need to demonstrate their health impacts scientifically, while developing innovative strategies to tackle both sustainability and nutritional health. In this frame, DOMINO will investigate the health impacts of FF-based diet on a healthy population and a cohort suffering from metabolic syndrome to better focus on health biomarkers. We will provide tailormade microbial solutions using an integrated ‘omics’ strategy and computational biology modelling to address the challenges associated with sustainable food production and healthy nutrition. In six food case studies, selected as representative of the wide diversity of plant-based FF prototypes, we will involve key stakeholders in a multi-actor approach. These objectives will lead to key results: the characterization of the health effect of milk kefir; the application of diagnosis tools based on healthy microbiome/human biomarkers to inform dietary recommendations based on FF for people with metabolic syndrome; the development of an open access database and new computational tools for profiling food microbiomes metabolic interaction during food fermentation and their overlap with the healthy gut microbiome; the delivery of a research and innovation workflow to facilitate the smart design of functional healthy FF, bio-waste valorisation, sustainable processes on plant-based food case studies using the leverage of food microbiomes’ biodiversity; all supported by a federation of key stakeholders and citizensthrough several living labs and a tailored dissemination strategy. Together we will develop and move towards a vision of the future of FFs in Europe while enhancing the trust of citizens in the food value chain through their involvement and genuine integration of their perspectives, paving the way for citizen-friendly innovation.