Identifying Markers of Chronic Pain Development in Alcoholism

识别酗酒者慢性疼痛发展的标志

• 批准号: 10385762
• 负责人: Nasim Maleki
• 金额: $ 18.31万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-10 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10385762
• 关键词: Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Analgesics; Anxiety; Brain; Brain Stem; Characteristics; Chronic; Data; Databases; Deterioration; Development; Diffusion; Disease; Down-Regulation; Early Diagnosis; Functional disorder; Heavy Drinking; Hippocampus (Brain); Hyperalgesia; Impairment; Individual; Interdisciplinary Study; Intervention; Lead; Link; Major Depressive Disorder; Mediating; Mental Depression; Mentored Research Scientist Development Award; Mentorship; Modeling; Motivation; Neural Pathways; Neurosciences; Nociception; Pain; Pain Research; Pain Threshold; Pathway interactions; Patients; Pattern; Play; Predictive Factor; Prefrontal Cortex; Process; Recording of previous events; Relapse; Reporting; Research; Rewards; Risk; Risk Factors; Role; Sensory; Spinal Cord; Statistical Models; Stimulus; Stress; Structure; Symptoms; Syndrome; System; Testing; Training; Up-Regulation; Woman; addiction; alcohol effect; alcohol relapse; alcohol risk; alcohol use disorder; alcohol use initiation; allodynia; base; career development; central sensitization; chronic alcohol ingestion; chronic back pain; chronic pain; chronic painful condition; cohort; cross disciplinary program; depressive symptoms; drinking; experience; insight; interdisciplinary approach; member; men; neuroadaptation; neuroimaging; neuropsychiatry; non-alcoholic; pain chronification; pain perception; pain processing; predictive marker; predictive modeling; problem drinker; relating to nervous system; response; sex; stress symptom

Summary This is an application for a Mentored Research Scientist Development Award (K01) to support the career development efforts of Dr. Nasim Maleki, including enhanced training in an integrated cross-disciplinary program consisting of in-depth experience in alcoholism neuroscience and pathophysiology under the mentorship of Dr. Marlene Oscar Berman, an expert at the forefront of research on alcohol abuse disorder (AUD), and a team of leading experts in alcoholism, pain, neuroimaging, and statistical modeling. The proposed research is an interdisciplinary study that would bridge AUD research with pain research and as such, allows insights into alcoholism as a risk factor for development of chronic pain disorders, and vice versa. Dr. Maleki aims to leverage neuroimaging and neuropsychiatric data from a large cohort of abstinent long-term alcoholic men and women, to develop retroactive insights and predictive models for chronic pain. Aim 1 seeks to determine whether AUD is associated with damage to the descending pain modulatory network (DPMN) pathways. Aim 2 is to gather further insights into potential abnormalities in the DPMN associated with AUD by performing quantitative sensory testing in AUD patients. Finally, Aim 3 will determine whether presence of depressive or stress symptoms are predictive of chronic pain development in AUD. As chronic pain syndromes have the propensity to trigger the risk of re-initiation of alcohol abuse in abstinent alcoholics, it is important to: (a) characterize pain related abnormalities associated with AUD; (b) understand neural links between AUD and chronic pain; and (c) ultimately identify markers that predict the risk of development of chronic pain in abstinent alcoholics. The findings should allow early detection of AUD patients at risk for developing chronic pain conditions, and earlier start of interventional approaches to reduce the risk of consequent alcohol abuse or relapse.

总结 这是一个指导研究科学家发展奖（K 01）的应用程序，以支持职业生涯 纳西姆·马利基博士的发展努力，包括加强综合跨学科培训， 该计划包括在酒精中毒神经科学和病理生理学下的深入经验， Marlene Oscar Berman博士的指导，她是酒精滥用障碍研究前沿的专家 (AUD)以及一个由酗酒、疼痛、神经成像和统计建模方面的顶尖专家组成的团队。拟议 研究是一个跨学科的研究，将桥梁AUD研究与疼痛研究，因此，允许 深入了解酗酒是慢性疼痛障碍发展的危险因素，反之亦然。马利基博士 目的是利用来自一个大的长期戒酒者队列的神经影像学和神经精神病学数据， 男性和女性，以开发慢性疼痛的追溯性见解和预测模型。目标1： 确定AUD是否与下行疼痛调节网络（DPMN）的损伤相关 途径。目的2是通过以下方法进一步了解与AUD相关的DPMN的潜在异常： 在AUD患者中进行定量感觉测试。最后，目标3将确定是否存在 抑郁或应激症状是AUD慢性疼痛发展的预测因素。作为慢性疼痛综合征 有可能引发戒酒酗酒者重新开始酗酒的风险，重要的是： (a)表征与AUD相关的疼痛相关的异常;（B）理解AUD和 慢性疼痛;和（c）最终确定预测禁欲者慢性疼痛发展风险的标志物。 酗酒者这些发现应该可以早期发现有慢性疼痛风险的AUD患者 条件，并尽早开始干预方法，以减少随之而来的酒精滥用的风险，或 复发