Identifying Markers of Chronic Pain Development in Alcoholism

摘要 这是一份申请导师研究科学家发展奖(K01)以支持职业生涯的申请书 Nasim Maleki博士的发展努力，包括加强综合跨学科培训 计划包括在酒精中毒神经科学和病理生理学方面的深入经验 玛琳·奥斯卡·伯曼博士的指导，他是酒精滥用障碍研究的前沿专家 (澳大利亚)，以及酒精中毒、疼痛、神经成像和统计建模方面的领先专家团队。建议数 研究是一项跨学科研究，将AUD研究与疼痛研究联系起来，因此，允许 对酗酒是慢性疼痛障碍发展的风险因素的洞察，反之亦然。马列基博士 旨在利用一大批长期戒酒者的神经成像和神经精神病学数据 男性和女性，以开发对慢性疼痛的追溯洞察力和预测模型。目标1寻求 确定AUD是否与下行痛觉调制网络(DPMN)受损有关 小路。目标2是通过以下方式收集对与AUD相关的DPMN潜在异常的进一步见解 对AUD患者进行定量感觉测试。最后，目标3将确定是否存在 抑郁或压力症状预示着AUD慢性疼痛的发展。作为慢性疼痛综合征 有再次引发戒酒者酗酒风险的倾向，重要的是： (A)描述与AUD相关的疼痛相关异常；(B)了解AUD和AUD之间的神经联系 慢性疼痛；和(C)最终确定预测戒毒者发生慢性疼痛风险的标志物 酗酒者。这一发现应该能够及早发现有慢性疼痛风险的AUD患者 情况，以及更早开始采取干预措施，以降低随后发生的酗酒或 旧病复发。

Summary This is an application for a Mentored Research Scientist Development Award (K01) to support the career development efforts of Dr. Nasim Maleki, including enhanced training in an integrated cross-disciplinary program consisting of in-depth experience in alcoholism neuroscience and pathophysiology under the mentorship of Dr. Marlene Oscar Berman, an expert at the forefront of research on alcohol abuse disorder (AUD), and a team of leading experts in alcoholism, pain, neuroimaging, and statistical modeling. The proposed research is an interdisciplinary study that would bridge AUD research with pain research and as such, allows insights into alcoholism as a risk factor for development of chronic pain disorders, and vice versa. Dr. Maleki aims to leverage neuroimaging and neuropsychiatric data from a large cohort of abstinent long-term alcoholic men and women, to develop retroactive insights and predictive models for chronic pain. Aim 1 seeks to determine whether AUD is associated with damage to the descending pain modulatory network (DPMN) pathways. Aim 2 is to gather further insights into potential abnormalities in the DPMN associated with AUD by performing quantitative sensory testing in AUD patients. Finally, Aim 3 will determine whether presence of depressive or stress symptoms are predictive of chronic pain development in AUD. As chronic pain syndromes have the propensity to trigger the risk of re-initiation of alcohol abuse in abstinent alcoholics, it is important to: (a) characterize pain related abnormalities associated with AUD; (b) understand neural links between AUD and chronic pain; and (c) ultimately identify markers that predict the risk of development of chronic pain in abstinent alcoholics. The findings should allow early detection of AUD patients at risk for developing chronic pain conditions, and earlier start of interventional approaches to reduce the risk of consequent alcohol abuse or relapse.