Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
基本信息
- 批准号:10388949
- 负责人:
- 金额:$ 20.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-10 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:Anaerobic BacteriaAnimalsBacteriaCollaborationsDietEngineeringEquipmentFundingGene ExpressionGnotobioticGoalsHealthHuman BiologyIndividualLettersMass Spectrum AnalysisMetabolismMicrobeMicrobial GeneticsMusNational Institute of General Medical SciencesPaperProcessResearchResearch PersonnelResearch Project GrantsShapesSteamSterilitySystemUniversitiesVariantWorkcostdisorder riskexperimental studyflexibilitygut microbiomegut microbiotamicrobialmicrobiomemicrobiome compositionmouse modelmutantparent grantparent projectresponsetool
项目摘要
Summary
The purpose of this proposal is to provide equipment support to our currently funded NIGMS
(R35GM118159) research project. Despite the possibility that the gut microbiome may represent a
critical and readily modifiable component of human biology, the contribution of the gut microbiota to
health, disease risk, and response to therapy remains largely undefined. The overall goal of the
parent grant is to understand the principles, mechanisms, and processes that shape the interaction
between gut microbial communities and their hosts. Our strategy is to combine anaerobic microbial
genetics and high-throughput mass spectrometry with gnotobiotic (germfree and ex-germfree) mouse
models to dissect these interactions. Gnotobiotic mice are the central experimental system that we're
using to conduct these studies. These animals, which are maintained in sterile flexible plastic
isolators or individually ventilated cages, lack any bacteria or other microbes. They can then be
compared to conventional animals that carry a normal microbiome, or colonized with individual
bacterial species, mutants of these species, or otherwise engineered strains in which gene
expression can be precisely controlled. Although we have made significant progress in the project (12
papers supported by GM118159), the main limitation is our restricted access to the steam sterilizer
(autoclave) equipment that is used to prepare every experiment. This limitation also reduces our
ability to engage in collaborations with multiple NIGMS-funded researchers at the university who
provide letters of support for this application. For these reasons, we request funds to partially support
the purchase of a steam sterilizer for gnotobiotics. The cost of this project is also being significantly
supported by the university.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew L Goodman其他文献
Andrew L Goodman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew L Goodman', 18)}}的其他基金
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10626934 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10018636 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10461800 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
9817111 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10798726 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10621815 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10406968 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
9294121 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10204342 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
9071690 - 财政年份:2016
- 资助金额:
$ 20.67万 - 项目类别:
相似海外基金
Automatic and accurate identification of aerobic bacteria, anaerobic bacteria, yeasts, and fungi in clinical samples derived from animals and from feed for pets
自动、准确地鉴定来自动物和宠物饲料的临床样品中的需氧细菌、厌氧细菌、酵母菌和真菌
- 批准号:
10440741 - 财政年份:2021
- 资助金额:
$ 20.67万 - 项目类别:
Bacterial Iron Acquisition Strategies of Gram-Negative Bacteria from the Pasteurellaceae that Inhabit the Upper Respiratory Tract of Food Production Animals
栖息在食品生产动物上呼吸道的巴斯德氏菌科革兰氏阴性菌的细菌铁获取策略
- 批准号:
RGPIN-2016-04555 - 财政年份:2021
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
NSFDEB-BSF: Evolution of truffles, morels, and relatives (Pezizales) and their interactions with animals, plants, and bacteria
NSFDEB-BSF:松露、羊肚菌和近缘植物(Pezizales)的进化及其与动物、植物和细菌的相互作用
- 批准号:
1946445 - 财政年份:2020
- 资助金额:
$ 20.67万 - 项目类别:
Standard Grant
Bacterial Iron Acquisition Strategies of Gram-Negative Bacteria from the Pasteurellaceae that Inhabit the Upper Respiratory Tract of Food Production Animals
栖息在食品生产动物上呼吸道的巴斯德氏菌科革兰氏阴性菌的细菌铁获取策略
- 批准号:
RGPIN-2016-04555 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
Molecular epidemiology of antimicrobial resistance plasmids in bacteria from animals
动物细菌中抗菌素耐药性质粒的分子流行病学
- 批准号:
RGPIN-2015-03962 - 财政年份:2019
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
Molecular epidemiology of antimicrobial resistance plasmids in bacteria from animals
动物细菌中抗菌素耐药性质粒的分子流行病学
- 批准号:
RGPIN-2015-03962 - 财政年份:2018
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
Development of Trait Control Technology on Micro-animals Based on Indigenous Bacteria and Its Application to Water Purification
基于本土细菌的微型动物性状控制技术开发及其在水净化中的应用
- 批准号:
18H03396 - 财政年份:2018
- 资助金额:
$ 20.67万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Bacterial Iron Acquisition Strategies of Gram-Negative Bacteria from the Pasteurellaceae that Inhabit the Upper Respiratory Tract of Food Production Animals
栖息在食品生产动物上呼吸道的巴斯德氏菌科革兰氏阴性菌的细菌铁获取策略
- 批准号:
RGPIN-2016-04555 - 财政年份:2018
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
Bacterial Iron Acquisition Strategies of Gram-Negative Bacteria from the Pasteurellaceae that Inhabit the Upper Respiratory Tract of Food Production Animals
栖息在食品生产动物上呼吸道的巴斯德氏菌科革兰氏阴性菌的细菌铁获取策略
- 批准号:
RGPIN-2016-04555 - 财政年份:2017
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual
Molecular epidemiology of antimicrobial resistance plasmids in bacteria from animals
动物细菌中抗菌素耐药性质粒的分子流行病学
- 批准号:
RGPIN-2015-03962 - 财政年份:2017
- 资助金额:
$ 20.67万 - 项目类别:
Discovery Grants Program - Individual