Causes and consequences of interpersonal microbial variation

人际微生物变异的原因和后果

基本信息

  • 批准号:
    10388949
  • 负责人:
  • 金额:
    $ 20.67万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-10 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

Summary The purpose of this proposal is to provide equipment support to our currently funded NIGMS (R35GM118159) research project. Despite the possibility that the gut microbiome may represent a critical and readily modifiable component of human biology, the contribution of the gut microbiota to health, disease risk, and response to therapy remains largely undefined. The overall goal of the parent grant is to understand the principles, mechanisms, and processes that shape the interaction between gut microbial communities and their hosts. Our strategy is to combine anaerobic microbial genetics and high-throughput mass spectrometry with gnotobiotic (germfree and ex-germfree) mouse models to dissect these interactions. Gnotobiotic mice are the central experimental system that we're using to conduct these studies. These animals, which are maintained in sterile flexible plastic isolators or individually ventilated cages, lack any bacteria or other microbes. They can then be compared to conventional animals that carry a normal microbiome, or colonized with individual bacterial species, mutants of these species, or otherwise engineered strains in which gene expression can be precisely controlled. Although we have made significant progress in the project (12 papers supported by GM118159), the main limitation is our restricted access to the steam sterilizer (autoclave) equipment that is used to prepare every experiment. This limitation also reduces our ability to engage in collaborations with multiple NIGMS-funded researchers at the university who provide letters of support for this application. For these reasons, we request funds to partially support the purchase of a steam sterilizer for gnotobiotics. The cost of this project is also being significantly supported by the university.
总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

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Andrew L Goodman其他文献

Andrew L Goodman的其他文献

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{{ truncateString('Andrew L Goodman', 18)}}的其他基金

Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10626934
  • 财政年份:
    2019
  • 资助金额:
    $ 20.67万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10018636
  • 财政年份:
    2019
  • 资助金额:
    $ 20.67万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10461800
  • 财政年份:
    2019
  • 资助金额:
    $ 20.67万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    9817111
  • 财政年份:
    2019
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10798726
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10621815
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10406968
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    9294121
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    9071690
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10204342
  • 财政年份:
    2016
  • 资助金额:
    $ 20.67万
  • 项目类别:

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自动、准确地鉴定来自动物和宠物饲料的临床样品中的需氧细菌、厌氧细菌、酵母菌和真菌
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