Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
基本信息
- 批准号:10798726
- 负责人:
- 金额:$ 25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-10 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AgingDietEquipmentFundingGerm-FreeGnotobioticGoalsHealthHuman BiologyMaintenanceMass Spectrum AnalysisMeasuresMetabolismMicrobial GeneticsMolecularNational Institute of General Medical SciencesPreparationProcessResearchResearch Project GrantsShapesSiteTimeUniversitiesVariantWorkaccess restrictionscostdietarydisorder riskgut microbiomegut microbiotainstrumentmass spectrometermicrobialmicrobiomemouse modelparent grantparent projecttreatment response
项目摘要
Summary
The purpose of this proposal is to provide equipment support to our currently funded NIGMS research
project (2R35GM118159-08). Despite the possibility that the gut microbiome may represent a critical
and readily modifiable component of human biology, the contribution of the gut microbiota to health,
disease risk, and response to therapy remains largely undefined. The overall goal of the parent grant
is to understand the principles, mechanisms, and processes that shape the interaction between gut
microbial communities and their hosts. Our strategy is to combine anaerobic microbial genetics and
high-throughput mass spectrometry with gnotobiotic (germfree and ex-germfree) mouse models to
dissect these interactions. The central analytical approach in these studies is mass spectrometry,
which we use to precisely measure microbial metabolism of dietary and other compounds and identify
metabolites produced as a result of these activities. Although we have made significant progress in
the project, the main limiting factor is the restricted access to time on a mass spectrometer. For this
reason, we request funds to partially support the purchase of a mass spectrometer to support this
project. The purchase cost, site preparation, installation, and maintenance of this instrument will also
be significantly supported by the university.
总结
这项建议的目的是为我们目前资助的NIGMS研究提供设备支持
项目(2 R35 GM 118159 -08)。尽管肠道微生物组可能代表了一个关键的
和人类生物学中容易改变的组成部分,肠道微生物群对健康的贡献,
疾病风险和对治疗的反应在很大程度上仍然不确定。父母补助金的总体目标
是了解的原则,机制,和过程,塑造肠道之间的相互作用,
微生物群落及其宿主。我们的策略是将联合收割机厌氧微生物遗传学和
使用无菌(无菌和无菌)小鼠模型进行高通量质谱分析,
剖析这些互动。这些研究中的中心分析方法是质谱法,
我们用它来精确测量饮食和其他化合物的微生物代谢,
由于这些活动而产生的代谢物。虽然我们在这方面取得了重大进展,
就该项目而言,主要的限制因素是质谱仪上的时间有限。为此
因此,我们要求资金部分支持购买质谱仪,以支持这一点。
项目该仪器的购买成本、场地准备、安装和维护也将
得到大学的大力支持。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut.
- DOI:10.1016/j.cell.2017.03.045
- 发表时间:2017-04-20
- 期刊:
- 影响因子:64.5
- 作者:Lim B;Zimmermann M;Barry NA;Goodman AL
- 通讯作者:Goodman AL
Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen.
- DOI:10.1128/mbio.01907-23
- 发表时间:2023-12-19
- 期刊:
- 影响因子:6.4
- 作者:
- 通讯作者:
A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor.
多形拟杆菌肠道定植的主要调节因子控制碳水化合物的利用和替代蛋白质合成因子。
- DOI:10.1128/mbio.03221-19
- 发表时间:2020
- 期刊:
- 影响因子:6.4
- 作者:Townsend2nd,GuyE;Han,Weiwei;Schwalm3rd,NathanD;Hong,Xinyu;Bencivenga-Barry,NatashaA;Goodman,AndrewL;Groisman,EduardoA
- 通讯作者:Groisman,EduardoA
An insider's perspective: Bacteroides as a window into the microbiome.
- DOI:10.1038/nmicrobiol.2017.26
- 发表时间:2017-04-25
- 期刊:
- 影响因子:28.3
- 作者:Wexler AG;Goodman AL
- 通讯作者:Goodman AL
A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria.
- DOI:10.1128/mbio.00656-21
- 发表时间:2021-08-31
- 期刊:
- 影响因子:6.4
- 作者:Bao Y;Verdegaal AA;Anderson BW;Barry NA;He J;Gao X;Goodman AL
- 通讯作者:Goodman AL
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew L Goodman其他文献
Andrew L Goodman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew L Goodman', 18)}}的其他基金
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10626934 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10018636 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
10461800 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
- 批准号:
9817111 - 财政年份:2019
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10621815 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10388949 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10406968 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
9294121 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
9071690 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
- 批准号:
10204342 - 财政年份:2016
- 资助金额:
$ 25万 - 项目类别:
相似国自然基金
基于DIET途径乙酸代谢的磺胺类抗生素胁迫响应机制解析与过程调控
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
废水厌氧生物处理种间直接电子转移(DIET)过程调控机制研究
- 批准号:
- 批准年份:2020
- 资助金额:59 万元
- 项目类别:
G. metallireducens与M. barkeri DIET方式耦合还原CO2产甲烷机理解析
- 批准号:31860011
- 批准年份:2018
- 资助金额:40.0 万元
- 项目类别:地区科学基金项目
相似海外基金
Role of CD206 surface antigen on M2 macrophages in the development of insulin resistance in the diet-induced obese mice model
M2巨噬细胞上CD206表面抗原在饮食诱导肥胖小鼠模型胰岛素抵抗发展中的作用
- 批准号:
24K19282 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Doctoral Dissertation Research: Assessing the physiological consequences of diet and environment for gorillas in zoological settings
博士论文研究:评估动物环境中大猩猩饮食和环境的生理后果
- 批准号:
2341433 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
BACMETH: Bacterial methylation of the human gut microbiome in response to diet for improvement of cardiometabolic health
BACMETH:人类肠道微生物组的细菌甲基化响应饮食以改善心脏代谢健康
- 批准号:
EP/Y023765/1 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Research Grant
Methylation of mRNA as a coupling mechanism between diet, metabolism and the circadian clock.
mRNA 甲基化作为饮食、新陈代谢和生物钟之间的耦合机制。
- 批准号:
MR/Y003896/1 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Fellowship
Co-DiRECT Nepal: a community-based diet programme for remission of type 2 diabetes and amelioration of non-communicable disease risks
Co-DiRECT 尼泊尔:旨在缓解 2 型糖尿病和改善非传染性疾病风险的社区饮食计划
- 批准号:
MR/Z000513/1 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Advancing biocultural and molecular studies of agriculturalist diet and nutrition.
博士论文研究:推进农业饮食和营养的生物文化和分子研究。
- 批准号:
2347683 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Standard Grant
CAREER: Carotenoid coloration in an evolutionary radiation: Connecting molecular function, fitness, and diet ecology in wood warblers
职业:进化辐射中的类胡萝卜素着色:连接林莺的分子功能、健康和饮食生态学
- 批准号:
2337828 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
Continuing Grant
A Varied Diet, Ageing, and the Evolution of Life Histories
多样化的饮食、衰老和生活史的演变
- 批准号:
FT230100240 - 财政年份:2024
- 资助金额:
$ 25万 - 项目类别:
ARC Future Fellowships
Large-Scale, Sustainable, Nutrient-Dense MicroVeg: Generating Health Evidence & Production Capacity to Support Incorporation into UK Diet
大规模、可持续、营养丰富的微型蔬菜:生成健康证据
- 批准号:
10072736 - 财政年份:2023
- 资助金额:
$ 25万 - 项目类别:
Collaborative R&D
NSH-PRICES: Prospective longitudinal study of health workers' purchasing and diet in response to food prices
NSH-价格:针对食品价格对卫生工作者购买和饮食的前瞻性纵向研究
- 批准号:
479145 - 财政年份:2023
- 资助金额:
$ 25万 - 项目类别:
Operating Grants