Causes and consequences of interpersonal microbial variation

人际微生物变异的原因和后果

基本信息

  • 批准号:
    10204342
  • 负责人:
  • 金额:
    $ 56.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-10 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

Project Summary The human gastrointestinal tract harbors trillions of commensal microbes that collectively encode 150-fold more genes than the human genome; between individuals, microbiome variation far exceeds genome variation. Despite the possibility that the microbiome may represent a critical and readily modifiable component of human biology, the contribution of the gut microbiota to health, disease risk, and response to therapy remains largely undefined. The overall goal of our laboratory is to understand the principles, mechanisms, and processes that shape the interaction between gut microbial communities and their hosts. Our strategy is to combine anaerobic microbial genetics, high-throughput mass spectrometry, and gnotobiotic (germfree and ex- germfree) animal models to dissect these interactions. In recent studies, we have used these approaches to measure the contribution of the human gut microbiome to the metabolism of medical drugs and to define cooperative, competitive, and antagonistic processes in the gut microbiome. Our progress in these areas provides the basis for future studies centered on two themes. We will apply the metabolomic approaches we developed for studying microbiome-mediated drug metabolism to xenobiotic compounds that aren't drugs, including molecular components of food. Microbial genetic and gnotobiotic approaches also enable investigation of how two processes that are not readily measured in microbiome surveys, within-host evolution and phenotypic heterogeneity, contribute to host-microbiome interaction in the healthy and perturbed gut environment. If successful, these studies will define causes and consequences of host-microbiome interaction with broad implications for human health.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Andrew L Goodman其他文献

Andrew L Goodman的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Andrew L Goodman', 18)}}的其他基金

Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10626934
  • 财政年份:
    2019
  • 资助金额:
    $ 56.64万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10018636
  • 财政年份:
    2019
  • 资助金额:
    $ 56.64万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    10461800
  • 财政年份:
    2019
  • 资助金额:
    $ 56.64万
  • 项目类别:
Understanding the contributions of microbiome-encoded drug metabolizing enzymes
了解微生物组编码的药物代谢酶的贡献
  • 批准号:
    9817111
  • 财政年份:
    2019
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10798726
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10621815
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10388949
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    10406968
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    9294121
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:
Causes and consequences of interpersonal microbial variation
人际微生物变异的原因和后果
  • 批准号:
    9071690
  • 财政年份:
    2016
  • 资助金额:
    $ 56.64万
  • 项目类别:

相似海外基金

Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
  • 批准号:
    495434
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
  • 批准号:
    10586596
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
  • 批准号:
    10590479
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
  • 批准号:
    10642519
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
  • 批准号:
    23K06011
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
  • 批准号:
    10682117
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
  • 批准号:
    10708517
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
  • 批准号:
    10575566
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
  • 批准号:
    23K15696
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
  • 批准号:
    23K15867
  • 财政年份:
    2023
  • 资助金额:
    $ 56.64万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了