Conduct of studies to evaluate the toxic and carcinogenic potential of sulfolane in laboratory animals

该项目的目标是为国家毒理学计划(DNTP)危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及在饮用水中暴露后，对大鼠和小鼠进行环丁砜的毒性和致癌性研究。在受污染的地下水中暴露后，特别是在阿拉斯加，人们对环丁磺酸的潜在毒性表示关切。来自该项目的数据将用于制定关于环丁砜对大鼠和小鼠的潜在毒性和致癌性的合理、科学的结论，并最终支持dNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众可充分了解因接触环丁砜而产生的危险因素。 关键词：毒性、致癌性、饮用水、环丁砜

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of sulfolane in rats and mice, following exposure in drinking water. There are concerns over the potential toxicity of sulfolane following exposure in contaminated ground water, particularly in Alaska. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of sulfolane in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to sulfolane. Keywords: toxicity, carcinogenicity, drinking water, sulfolane