Conduct of studies to evaluate the toxic and carcinogenic potential of sulfolane in laboratory animals

进行研究以评估环丁砜对实验动物的毒性和致癌潜力

• 批准号: 10388053
• 负责人: BARNEY SPARROW
• 金额: $ 16.68万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388053
• 关键词: Adverse effects; Alaska; Chemicals; Data; Development; Ensure; Environmental Exposure; Evaluation; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; Mission; Mus; National Toxicology Program; Pathology; Peer Review; Phase; Rattus; Reporting; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; carcinogenicity; disorder prevention; drinking water; ground water; immunotoxicity; public health research; sound

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of sulfolane in rats and mice, following exposure in drinking water. There are concerns over the potential toxicity of sulfolane following exposure in contaminated ground water, particularly in Alaska. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of sulfolane in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to sulfolane. Keywords: toxicity, carcinogenicity, drinking water, sulfolane

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及在饮用水中暴露后对大鼠和小鼠进行磺烷的毒性和致癌性研究。人们担心，在受到污染的地下水中，特别是在阿拉斯加，接触到环己烷可能会产生毒性。该项目的数据将用于对大鼠和小鼠的潜在毒性和致癌性得出合理的科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解因接触亚砜而产生的风险因素。