Conduct of studies to evaluate the toxic and carcinogenic potential of sulfolane in laboratory animals

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及在大鼠和小鼠接触饮用水后进行环丁砜的毒性和致癌性研究。人们担心环丁砜在接触受污染的地下水后可能产生毒性，特别是在阿拉斯加。该项目的数据将用于制定关于环丁砜在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解接触环丁砜所产生的风险因素。 关键词：毒性，致癌性，饮用水，环丁砜

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of sulfolane in rats and mice, following exposure in drinking water. There are concerns over the potential toxicity of sulfolane following exposure in contaminated ground water, particularly in Alaska. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of sulfolane in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to sulfolane. Keywords: toxicity, carcinogenicity, drinking water, sulfolane