Optimizing health from pregnancy through one year postpartum: A sequential multiple assignment randomized trial (SMART) of perinatal lifestyle intervention

优化从怀孕到产后一年的健康：围产期生活方式干预的序贯多重分配随机试验 (SMART)

• 批准号: 10392312
• 负责人: MICHELE D LEVINE
• 金额: $ 36.84万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392312
• 关键词: Address; Administrative Supplement; Affect; Area; Attenuated; Behavior; Behavioral; Behavioral trial; Body mass index; COVID-19; COVID-19 pandemic; Caring; Data Collection; Dietary intake; Discrimination; Exposure to; Face; Food; Goals; Grant; Health; Health behavior; Intervention; Maternal Health; Measures; Mental Health; Modeling; Moods; Mothers; Obesity; Outcome; Overweight; Parents; Pennsylvania; Perinatal; Personal Satisfaction; Physical activity; Postpartum Period; Pregnancy; Pregnant Women; Psychosocial Stress; Reporting; Research; Risk; Role; Sampling; Sequential Multiple Assignment Randomized Trial; Sleep; Social Environment; Stress; Structural Racism; United States National Institutes of Health; Weight; Woman; Women' s Health; adverse maternal outcomes; biopsychosocial; black women; comparison intervention; depressive symptoms; evidence base; food insecurity; improved; lifestyle intervention; maternal weight; neonatal outcome; novel; pandemic disease; perinatal health; perinatal intervention; perinatal period; pregnant; prepregnancy; psychoeducation; psychosocial; racial discrimination; racial health disparity; racism; randomized trial; recruit; response; stress management; stressor; treatment as usual

ABSTRACT We are currently recruiting women with overweight/obesity (prepregnancy BMI ≥ 25) at the beginning of pregnancy into a two-stage randomized trial of lifestyle interventions delivered across pregnancy and the first year postpartum (R01HL132578). In response to NOT-OD-21-071 “Administrative Supplements and Urgent Competitive Revisions for NIH Grants to Add or Expand Research Focused on Maternal Health, Structural Racism and Discrimination (SRD), and COVID-19,” we propose to enhance the aims of our ongoing trial of perinatal lifestyle interventions, “Optimizing Health from Pregnancy through One Year Postpartum: A Sequential Multiple Assignment Randomized Trial [SMART] of Perinatal Lifestyle Intervention” to address questions about the ways in which the COVID-19 pandemic and structural racism and discrimination (SRD) affect perinatal health and mental health. We propose to enhance the aims of our ongoing trial in several ways. First, we aim to evaluate the effects of the COVID-19 pandemic on weight, weight-related behaviors, depressive symptoms, and psychosocial stress among women with prepregnancy overweight/obesity from pregnancy to 6 months postpartum and examine the potential for behavioral and psychosocial intervention delivered during the perinatal period to attenuate negative effects of the pandemic on maternal health and mental health. Second, we propose to add assessments of food insecurity and racial discrimination. Given the disproportionate effects of the COVID-19 pandemic on Black women’s health, we will enhance our sample by recruiting 40 additional Black pregnant women (prepregnancy BMI ≥ 25). The added assessments of food insecurity and discrimination will supplement measures of dietary intake, physical activity, depressive symptoms, psychosocial stress, sleep, and weight collected in the parent R01. Intervention components such as psychoeducation, coaching, goal-setting, and support related to health behavior promotion, mood and stress management can address stressors related to the pandemic, and the myriad challenges and concerns women face during pregnancy and postpartum. The aims of this supplement are to: (1) Examine the impact of the COVID-19 pandemic on weight, weight-related behaviors, depressive symptoms, and psychosocial stress in women with overweight/obesity at the end of pregnancy and 6 months postpartum; (2) Determine whether perinatal lifestyle intervention attenuates negative pandemic-related effects on weight, weight-related behaviors and mental health; and (3) Evaluate food insecurity and perceived discrimination in relation to maternal weight, mental health outcomes, and lifestyle intervention response. Thus, we aim to leverage the ongoing R01 to contribute an evidence base to improve care by documenting the potential for lifestyle intervention to attenuate negative impacts of the COVID-19 pandemic on perinatal maternal health and mental health.

摘要

项目成果

Taste manipulation during a food cue-reactivity task: Effects on cue-elicited food craving and subsequent food intake among individuals with overweight and obesity.

食物提示反应任务期间的味觉操纵：对超重和肥胖个体中提示引起的食物渴望和随后的食物摄入的影响。

• DOI: 10.1016/j.eatbeh.2019.03.005
• 发表时间: 2019
• 期刊: Eating behaviors
• 影响因子: 2.8
• 作者: Germeroth,LisaJ;Wallace,MeredithL;Levine,MicheleD
• 通讯作者: Levine,MicheleD