The Development of Tabletop Brain-Mapping Platform
桌面脑图平台的开发
基本信息
- 批准号:10395196
- 负责人:
- 金额:$ 44.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAgarAnatomyAreaAtlasesBRAIN initiativeBrainBrain MappingBrain imagingBrain regionBudgetsCentral Nervous System DiseasesClientComplexComputer softwareDevelopmentDevicesEnsureEquipmentFaceFeedbackFluorescenceFoundationsGlassHistologyHuman ResourcesHumidifierImageImmunohistochemistryIndividualInstitutesLaboratoriesLocationManualsMapsMethodsMicroscopeMicrotome - medical deviceMicrotomyMusNamesNerve DegenerationNeuraxisNeurosciencesOrganPatternPhasePriceProcessProductionProtocols documentationResearchSeriesSliceSlideSocietiesSoftware ToolsStainsSurveysSystemTaxusTechniquesTechnologyTestingTherapeuticThickThinnessTissue imagingTissuesTo specifyWorkbasecell typecommercializationcostcost effectivedesign and constructiondigitalexperienceimage processingimprovedindexinginstrumentinstrumentationinterestmultiphoton imagingnovel therapeuticsrelating to nervous systemsample fixationsecondary analysissoftware developmenttissue preparationtissue processingtomographytooltwo-photon
项目摘要
PROJECT SUMMARY
Central Nervous System (CNS) disorders place an enormous burden on society and have proven
to be among the most challenging areas for which to develop a therapeutic. A major reason for
this is that the brain is a complex, 3D, multiscale organ, with a heterogenous distribution of
components across hundreds of brain regions. Extensive BRAIN Initiative efforts are underway
to map this complexity by conducting surveys of connectivity pattern and cells types. Digital
brain atlases such as the Allen Mouse Brain CCF v3.0 have become essential tools in organizing
the results of these endeavors.
The availability of the Allen CCFV3.0 and whole-brain surveys are transforming CNS studies.
However, brain mapping still too frequently requires access to expensive equipment, specialized
techniques, and dedicated personnel. Moreover, many newer techniques are incompatible with
established histology protocols, which severely limits the contribution of foundational
techniques to brain mapping efforts. In addition, the tedious manual production of slides
remains a significant obstacle to high throughput histology. These difficulties present a
significant barrier to the field and hinders progress in understanding the CNS.
This proposal will remove these barriers by developing an affordable, table-top hardware and
software mouse brain imaging and tissue processing platform accessible to the non-specialist
neuroscience lab. It is based on the proven microtomy, section capture, and slide mounting
technology contained in TissueVision's commercially successfully state-of-the-art multiphoton-
based TissueCyte platform. This proposal will extend the capabilities of our current system and
extend it to sections as thin as 15 microns and replace the TissueCyte's advanced multiphoton
imaging with less expensive block-face imaging. In Phase II we will be package the integrated
tissue processing technology into a convenient, compact instrument. This table-top, affordable
device will combine the ease of working from 2D sections with the power of 3D brain analyses
and help propel forward the development of new therapeutics.
This product will be brought to market by a team of world-class experts at TissueVision who
have successful commercialization experience in instrumentation for high throughput histology
and brain mapping. We will be aided by a superb network of partners in leading neuroscience
labs who will beta test the product and provide crucial feedback in Phase II to ensure a
successful product launch and acceptance into the marketplace.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Timothy M. Ragan其他文献
Timothy M. Ragan的其他文献
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{{ truncateString('Timothy M. Ragan', 18)}}的其他基金
A high throughput multiplexed pipeline for models of Alzheimer’s Disease
用于阿尔茨海默病模型的高通量多重管道
- 批准号:
10766665 - 财政年份:2023
- 资助金额:
$ 44.89万 - 项目类别:
The Development of Tabletop Brain-Mapping Platform
桌面脑图平台的开发
- 批准号:
10487512 - 财政年份:2021
- 资助金额:
$ 44.89万 - 项目类别:
An Automated platform for 3D reconstruction and profiling of post-mortem Alzheimer's Disease brains
用于对死后阿尔茨海默病大脑进行 3D 重建和分析的自动化平台
- 批准号:
10395363 - 财政年份:2021
- 资助金额:
$ 44.89万 - 项目类别:
The Development of a High Throughput Whole Brain Alzheimer's Disease Drug Screening Pipeline
高通量全脑阿尔茨海默病药物筛选流程的开发
- 批准号:
10161681 - 财政年份:2018
- 资助金额:
$ 44.89万 - 项目类别:
High Speed Multiphoton Multifocal Whole Brain Imaging
高速多光子多焦全脑成像
- 批准号:
9358345 - 财政年份:2014
- 资助金额:
$ 44.89万 - 项目类别:
High Speed Multiphoton Multifocal Whole Brain Imaging
高速多光子多焦全脑成像
- 批准号:
8781939 - 财政年份:2014
- 资助金额:
$ 44.89万 - 项目类别:
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