Bilateral Brain Dynamics Supporting Cognition in Normal Aging and Dementia

双侧大脑动力学支持正常衰老和痴呆症的认知

• 批准号: 10395738
• 负责人: Simon W Davis
• 金额: $ 4.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395738
• 关键词: Achievement; Address; Administrative Supplement; Adult; Affect; Alzheimer' s Disease; Attention; Award; Behavior; Behavioral; Bilateral; Brain; Brain region; Budgets; COVID-19 pandemic; Clinical; Cognition; Cognitive deficits; Communication; Contralateral; Corpus Callosum; Dementia; Development; Effectiveness; Elderly; Electroencephalography; Electrophysiology (science); Episodic memory; Foundations; Functional Magnetic Resonance Imaging; Funding; Genetic; Global Change; Goals; Impaired cognition; Impairment; Intervention; Knowledge; Left; Link; Manuscripts; Measures; Mediating; Memory; Memory impairment; Neuronal Plasticity; Neurons; Neurophysiology - biologic function; Neuropsychology; Neurosciences; Parents; Participant; Pathway interactions; Patients; Pattern; Performance; Phase; Physiologic pulse; Population; Prefrontal Cortex; Protocols documentation; Public Health; Publications; Research; Resolution; Resources; Risk; Risk Factors; Role; Semantics; Side; Site; Specificity; Structure; Task Performances; Technology; Testing; Therapeutic; Time; Transcranial magnetic stimulation; Work; age related; aging brain; amnestic mild cognitive impairment; base; behavioral outcome; brain health; clinically significant; cognitive benefits; cognitive enhancement; cognitive function; cognitive process; cohort; cost; design; effective therapy; executive function; experimental study; improved; indexing; insight; memory encoding; mild cognitive impairment; multimodality; network models; neurodegenerative dementia; neuroimaging; neuromechanism; normal aging; novel; novel strategies; relating to nervous system; spatiotemporal; symposium; tool; young adult

Project Summary This is an application for an Funded Extension (Administrative Supplement award) to an existing project, Using fMRI-guided TMS to increase central executive function in older adults. This award will provide our team with the support necessary to extend our existing EEG-TMS paradigm to patients with a prodromal form of Alzheimer’s Disease (AD) known as amnestic Mild Cognitive Impairment (MCI), and investigate the role of brain health factors in mediating the TMS-related memory performance benefits associated with communication between a network of frontoparietal brain regions in these populations. The main goal of the project is to address develop a novel approach to memory-based neurostimulation therapies. Neurostimulation affects multiple sites within a cortical network, but these global effects have not been used as targets for stimulation because of limited knowledge about what influence these localized sites have on global changes in brain state. To address this problem, we will use multimodal neuroimaging tools and network modeling approaches developed though the parent U01 project, to demonstrate how focal neurostimulation improves the efficacy of TMS for enhancing memory function. These goals will be addressed in the Administrative Supplement under our three specific aims. In Aim 1, Dr. Davis will establish the spatial specificity of bilateral brain mechanisms with combination of behavior and high-resolution structural neuroimaging in cortical sites known to be active during memory encoding. In Aim 2, Dr. Davis will establish the underlying dynamics of interhemispheric frontal communication using a novel combination of single-sided TMS, rTMS entraining conditions, and electroencephalography (EEG) to establish the coordinated activity between the hemispheres; Lastly, in Aim 3, Dr. Davis will use the rTMS entraining parameters delineated in Aim 2 to promote specific cross- hemispheric communication, applied to participants performing a Word Encoding task, a general task of memory performance. The ongoing work will provide an important tool for studying the dynamics of network connectivity of memory states in the aging brain, as well as new information on the effectiveness of brain stimulation technologies as a therapeutic approach for cognitive decline. The parent K01 project has made foundational advances towards these goals, as we have demonstrated the ability of to selectively modulate memory-related neural functions in healthy older adults and MCI. The project has proceeded successfully through Years 1-3, with multiple conference publications and prepared manuscripts, and the achievement of developmental goals in Clinical and Electrophysiology didactics. However, as outlined in the Budget Justification, the project has incurred a significant delay due to the COVID- 19 global pandemic, and in order to complete the project we request additional funds through this Supplement. The scientific goals and approach remain unchanged from the original proposal.

项目摘要 这是使用现有项目的资助扩展名（行政补充裁决）的申请 fMRI引导的TMS可以增加老年人中心执行功能。该奖项将为我们的团队提供 将我们现有的EEG-TMS范式扩展到具有前途形式的患者所必需的支持 阿尔茨海默氏病（AD）称为柔韧性轻度认知障碍（MCI），并研究 介导与TMS相关的内存性能优势的大脑健康因素 这些人群中额叶大脑区域网络之间的通信。 该项目的主要目标是解决开发一种基于内存神经刺激的新方法 疗法。神经刺激会影响皮质网络中的多个位点，但是这些全球效应并非 由于对这些本地地点对这些影响的影响有限，因此用作刺激的目标 大脑状态的全球变化。为了解决这个问题，我们将使用多模式神经影像学工具和网络 通过母体U01项目开发了建模方法，以证明局灶性神经刺激如何 提高TMS增强内存功能的效率。这些目标将在行政中解决 根据我们的三个特定目标补充。在AIM 1中，戴维斯博士将建立双边的空间特异性 在皮质部位的行为和高分辨率结构神经影像的结合的大脑机制 已知在记忆编码期间处于活动状态。在AIM 2中，戴维斯博士将建立基本动力 使用单面TMS的新型组合RTMS组成 条件和脑电图（EEG）建立半球之间的协调活性； 最后，在AIM 3中，戴维斯博士将使用AIM 2中描述的RTMS入口参数来促进特定的跨界 半球通信，应用于执行单词编码任务的参与者，这是记忆的一般任务 表现。正在进行的工作将为研究网络连接的动态提供重要的工具 大脑衰老的记忆状态以及有关大脑刺激有效性的新信息 技术作为认知能力下降的治疗方法。 正如我们已经证明的那样 在健康的老年人和MCI中选择性调节与记忆相关的神经功能的能力。 项目在1 - 3年内成功地进行了多个会议出版物并准备 手稿，以及实现临床和电生理教学学中的发展目标。 但是，正如预算辩护中概述的那样，由于该项目，该项目由于共同造成了重大延误 19全球大流行，为了完成该项目，我们通过此补品要求其他资金。 科学目标和方法与原始提案保持不变。