Bilateral Brain Dynamics Supporting Cognition in Normal Aging and Dementia
双侧大脑动力学支持正常衰老和痴呆症的认知
基本信息
- 批准号:9386501
- 负责人:
- 金额:$ 11.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAge-associated memory impairmentAgingAlzheimer&aposs DiseaseApplications GrantsAttentionBasic ScienceBehaviorBehavioralBilateralBrainClinicalClinical ResearchCognitionCognition DisordersCognitiveCognitive deficitsCommunicationContralateralCorpus CallosumDementiaDevelopmentDisease ProgressionEffectivenessElderlyElectroencephalographyElectrophysiology (science)Episodic memoryExhibitsFoundationsGoalsHealthImpaired cognitionImpairmentInstitutesInterventionInvestigationK-Series Research Career ProgramsLeftLinkLongevityLongitudinal StudiesMeasuresMedicalMemoryMemory DisordersMentored Research Scientist Development AwardMentorsNeurodegenerative DisordersNeurologyNeuronal PlasticityNeuronsNeurosciencesNeurotransmittersOlder PopulationOutcome StudyParticipantPathway interactionsPatient-Focused OutcomesPatientsPatternPerformancePhasePhysiologic pulsePopulationPrefrontal CortexProtocols documentationPublic HealthResearchResearch PersonnelResolutionResourcesRiskRisk FactorsRoleScienceSemantic memorySemanticsSideSiteSpecificitySystemTask PerformancesTechniquesTestingTherapeuticTimeTranscranial magnetic stimulationTranslational ResearchTreatment EfficacyTreatment ProtocolsWorkage relatedamnestic mild cognitive impairmentattentional controlbasebehavioral outcomeclinically significantcognitive controlcognitive enhancementcognitive functioncognitive processcohortdaily functioningdementeddesigneffective therapyexperienceexperimental studyimprovedindexingmemory encodingmortalitymultimodalityneurodegenerative dementianeuroimagingneuromechanismnormal agingnovelpre-clinicalprofessorrelating to nervous systemspatiotemporaltherapy developmenttranslational studyyoung adult
项目摘要
PROJECT SUMMARY
This is an application for a K01 award to Dr. Simon Davis, an Assistant Professor and cognitive neuroscientist
at the Duke Institute of Brain Sciences, a scientific institute that supports researchers bridging basic science
and translational applications. Dr. Davis is establishing himself as a young investigator in both basic and
translational research of age-related disorders of cognition. This K01 award will provide Dr. Davis with the
support necessary to accomplish the following goals: (1) become an expert in Cognitive Electrophysiology
(EEG) and Clinical Research, with a focus on Alzheimer’s Disease (AD), (2) gain practical expertise in
electrophysiological approaches to hemispheric communication during memory, (3) integrate novel brain
stimulation and EEG techniques in both basic and translational studies, and (4) develop novel brain stimulation
protocols to enhance attentional control and memory in normative and demented elderly populations. To
achieve these goals, Dr. Davis, who has a background on the neural mechanisms of episodic and semantic
memory, has assembled a mentoring team comprised of his primary mentor, Dr. Marty G. Woldorff, a senior
cognitive neuroscientist with extensive experience in electrophysiological studies of attentional and cognitive
control, and co-mentor Dr. Richard O’Brien, Chair of the Neurology Department at Duke, who has extensive
experience conducting multimethodological investigations of aging and neurodegenerative disease, including
AD and amnestic Mild Cognitive Impairment (MCI-AD), the population examined in the current proposal.
This proposal is focused on the gap in understanding of bilateral brain interactions and their role in helping
normative and clinical elderly populations maintain cognitive health. Dr. Davis’ research will focus on
investigating this neural mechanism of these interactions and promoting them with a precise application of
TMS, in order to test the hypothesis that excitatory interactions between the hemispheres can provide positive
outcomes for patients with pre-clinical AD (amnestic Mild Cognitive Impairment or MCI-AD). In Aim 1, Dr.
Davis will establish the spatial specificity of bilateral brain mechanisms with combination of behavior and high-
resolution structural neuroimaging in cortical sites known to be active during memory encoding. In Aim 2, Dr.
Davis will establish the underlying dynamics of interhemispheric frontal communication using a novel
combination of single-sided TMS, rTMS entraining conditions, and electroencephalography (EEG) to establish
the coordinated activity between the hemispheres; Lastly, in Aim 3, Dr. Davis will use the rTMS entraining
parameters delineated in Aim 2 to promote specific cross-hemispheric communication, applied to participants
performing a Picture Encoding task, a general task of memory performance. The outcome of these studies will
allow Dr. Davis to evaluate the strength of this brain stimulation protocol in alleviating age-related and
dementia-related cognitive decline. This research will enable development of novel treatment protocols for
dementia in elderly cohorts, and form the basis of a longitudinal study in neurodegenerative disease that will be
proposed in an R01 grant application before the termination of the K award.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Simon W Davis其他文献
Simon W Davis的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Simon W Davis', 18)}}的其他基金
Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia
衰老和痴呆症中工作记忆网络的自适应神经调节
- 批准号:
10701758 - 财政年份:2022
- 资助金额:
$ 11.45万 - 项目类别:
Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia
衰老和痴呆症中工作记忆网络的自适应神经调节
- 批准号:
10526714 - 财政年份:2022
- 资助金额:
$ 11.45万 - 项目类别:
Bilateral Brain Dynamics Supporting Cognition in Normal Aging and Dementia
双侧大脑动力学支持正常衰老和痴呆症的认知
- 批准号:
10395738 - 财政年份:2017
- 资助金额:
$ 11.45万 - 项目类别:
White-matter connectivity and the reorganization of brain networks in aging
衰老过程中的白质连接和大脑网络重组
- 批准号:
7696447 - 财政年份:2008
- 资助金额:
$ 11.45万 - 项目类别:
White-matter connectivity and the reorganization of brain networks in aging
衰老过程中的白质连接和大脑网络重组
- 批准号:
7613260 - 财政年份:2008
- 资助金额:
$ 11.45万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 11.45万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 11.45万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 11.45万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 11.45万 - 项目类别:
Grant-in-Aid for Early-Career Scientists