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Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

少数族裔的饮食相关炎症和肾功能下降

基本信息

批准号：
10392475
负责人：
Tanya Johns
金额：
$ 18.8万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10392475
关键词：
Address Advisory Committees Affect African American African American population Albuminuria Alzheimer&apos s disease risk American Ancillary Study Anti-Inflammatory Agents Award Benchmarking Biological Markers Biometry Chronic Chronic Kidney Failure Clinical Clinical Investigator Clinical Trials Cognition Cohort Studies Communities Comparative Effectiveness Research Cross-Sectional Studies Cultural Diversity Data Data Analyses Development Diet Dietary Intervention Dietary Practices Disease Progression Enrollment Environment Ethnic group European Experimental Models Feasibility Studies Food Preferences Funding Goals Health Health Disparities Research Healthy Eating Hispanic Hispanic Community Health Study/Study of Latinos Hispanic Populations Impaired cognition Individual Inflammation Inflammatory Interleukin-6 Intervention Jackson Heart Study Journals Kidney Kidney Diseases Knowledge Longitudinal Studies Measures Mediating Medical center Medicine Mediterranean Diet Mentors Mentorship Minority Groups Morbidity - disease rate Nephrology Non-Insulin-Dependent Diabetes Mellitus Outcome Oxidative Stress Participant Pattern Pilot Projects Population Heterogeneity Prevention Publications Randomized Controlled Trials Reduce health disparities Renal function Research Research Personnel Research Proposals Research Training Resources Risk Risk Factors TNF gene Testing Text Training United States National Institutes of Health Ursidae Family Woman Women&apos s Health Work Writing acceptability and feasibility arm career career development clinical trial implementation cohort college comparative effectiveness study cost design dietary dietary approach disorder risk endothelial dysfunction ethnic minority experience functional decline good diet health disparity high risk improved indexing intervention effect lifestyle factors low socioeconomic status meetings member mortality multidisciplinary novel nutrition nutritional epidemiology programs racial and ethnic recruit renal damage research and development skills systemic inflammatory response therapeutic target treatment arm western diet

项目摘要

PROJECT SUMMARY/ ABSTRACT: The primary purpose of this proposal is to provide Tanya Johns, MD, MHS, a clinical investigator in the Department of Medicine (Division of Nephrology) at Albert Einstein College of Medicine/ Montefiore Medical Center, with the skills and mentored guidance necessary to develop into an independent clinical researcher and a nationally recognized expert focused on reducing health disparities in chronic kidney disease (CKD). Dr. Johns’ research proposal examines the relationship between dietary patterns and inflammation, and its association with kidney function decline in racial/ethnic minorities. Growing evidence suggests that pro- inflammatory dietary patterns may adversely impact kidney health; but this has not been fully investigated, especially in minority populations who bear an excess burden of CKD. Dr. Johns will leverage large, well- established NIH funded cohorts of racial/ethnic minorities with longitudinal data to test the association of diet- induced inflammation with kidney function decline. She will also examine the effects of the Multicultural Healthy Diet (anti-inflammatory dietary pattern) intervention on CKD risk, and the feasibility in individuals with established CKD. Specifically, she aims to: 1) characterize dietary patterns in community-dwelling African Americans (n= 5,306) and Hispanics (n= 16,415) and its associations with systemic inflammation and kidney function decline; 2) evaluate the effect of the Multicultural Healthy Dietary (MHD) intervention on CKD risk in an ongoing clinical trial of older predominately racial/ethnic minority participants (n= 277); and 3) conduct a small pilot study (n= 20) to evaluate the feasibility and acceptability of a MHD-like intervention in racial/ethnic minorities with CKD. To successfully complete these research aims and transition to independence, Dr. Johns has developed a comprehensive 3-year research program that includes: i) mentorship from a multidisciplinary team with expertise in nutrition, longitudinal data analyses for cohort studies, clinical trials, comparative effectiveness studies, and health disparities research; ii) completion of courses in nutritional epidemiology, biostatistics, comparative effectiveness research, and clinical trials; iii) dissemination of her work through presentations at national research meetings and publications in high impact journals; iv) grantsmanship activities geared towards writing a competitive R01 by the end of her award period. Each member of Dr. Johns’ mentorship team has a long track record of successfully mentoring junior investigators, and is fully committed to working together to help her achieve career benchmarks and attain research independence. The resources at Albert Einstein provides an ideal environment in which to complete her training and research goals. With the knowledge and expertise gained from her research and career development activities, Dr. Johns will be well poised to evaluate novel risk factors for CKD, which will inform the development and implementation dietary or other interventions to halt kidney disease initiation and progression in racial/ ethnic minorities. With this award, Dr. Tanya Johns will be well prepared for a career as an independent clinical investigator. (30 lines; Limit 30 lines of text)

项目摘要/摘要：