Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

少数族裔的饮食相关炎症和肾功能下降

• 批准号: 10392475
• 负责人: Tanya Johns
• 金额: $ 18.8万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392475
• 关键词: Address; Advisory Committees; Affect; African American; African American population; Albuminuria; Alzheimer' s disease risk; American; Ancillary Study; Anti-Inflammatory Agents; Award; Benchmarking; Biological Markers; Biometry; Chronic; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Communities; Comparative Effectiveness Research; Cross-Sectional Studies; Cultural Diversity; Data; Data Analyses; Development; Diet; Dietary Intervention; Dietary Practices; Disease Progression; Enrollment; Environment; Ethnic group; European; Experimental Models; Feasibility Studies; Food Preferences; Funding; Goals; Health; Health Disparities Research; Healthy Eating; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Jackson Heart Study; Journals; Kidney; Kidney Diseases; Knowledge; Longitudinal Studies; Measures; Mediating; Medical center; Medicine; Mediterranean Diet; Mentors; Mentorship; Minority Groups; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Oxidative Stress; Participant; Pattern; Pilot Projects; Population Heterogeneity; Prevention; Publications; Randomized Controlled Trials; Reduce health disparities; Renal function; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk; Risk Factors; TNF gene; Testing; Text; Training; United States National Institutes of Health; Ursidae Family; Woman; Women' s Health; Work; Writing; acceptability and feasibility; arm; career; career development; clinical trial implementation; cohort; college; comparative effectiveness study; cost; design; dietary; dietary approach; disorder risk; endothelial dysfunction; ethnic minority; experience; functional decline; good diet; health disparity; high risk; improved; indexing; intervention effect; lifestyle factors; low socioeconomic status; meetings; member; mortality; multidisciplinary; novel; nutrition; nutritional epidemiology; programs; racial and ethnic; recruit; renal damage; research and development; skills; systemic inflammatory response; therapeutic target; treatment arm; western diet

PROJECT SUMMARY/ ABSTRACT: The primary purpose of this proposal is to provide Tanya Johns, MD, MHS, a clinical investigator in the Department of Medicine (Division of Nephrology) at Albert Einstein College of Medicine/ Montefiore Medical Center, with the skills and mentored guidance necessary to develop into an independent clinical researcher and a nationally recognized expert focused on reducing health disparities in chronic kidney disease (CKD). Dr. Johns’ research proposal examines the relationship between dietary patterns and inflammation, and its association with kidney function decline in racial/ethnic minorities. Growing evidence suggests that pro- inflammatory dietary patterns may adversely impact kidney health; but this has not been fully investigated, especially in minority populations who bear an excess burden of CKD. Dr. Johns will leverage large, well- established NIH funded cohorts of racial/ethnic minorities with longitudinal data to test the association of diet- induced inflammation with kidney function decline. She will also examine the effects of the Multicultural Healthy Diet (anti-inflammatory dietary pattern) intervention on CKD risk, and the feasibility in individuals with established CKD. Specifically, she aims to: 1) characterize dietary patterns in community-dwelling African Americans (n= 5,306) and Hispanics (n= 16,415) and its associations with systemic inflammation and kidney function decline; 2) evaluate the effect of the Multicultural Healthy Dietary (MHD) intervention on CKD risk in an ongoing clinical trial of older predominately racial/ethnic minority participants (n= 277); and 3) conduct a small pilot study (n= 20) to evaluate the feasibility and acceptability of a MHD-like intervention in racial/ethnic minorities with CKD. To successfully complete these research aims and transition to independence, Dr. Johns has developed a comprehensive 3-year research program that includes: i) mentorship from a multidisciplinary team with expertise in nutrition, longitudinal data analyses for cohort studies, clinical trials, comparative effectiveness studies, and health disparities research; ii) completion of courses in nutritional epidemiology, biostatistics, comparative effectiveness research, and clinical trials; iii) dissemination of her work through presentations at national research meetings and publications in high impact journals; iv) grantsmanship activities geared towards writing a competitive R01 by the end of her award period. Each member of Dr. Johns’ mentorship team has a long track record of successfully mentoring junior investigators, and is fully committed to working together to help her achieve career benchmarks and attain research independence. The resources at Albert Einstein provides an ideal environment in which to complete her training and research goals. With the knowledge and expertise gained from her research and career development activities, Dr. Johns will be well poised to evaluate novel risk factors for CKD, which will inform the development and implementation dietary or other interventions to halt kidney disease initiation and progression in racial/ ethnic minorities. With this award, Dr. Tanya Johns will be well prepared for a career as an independent clinical investigator. (30 lines; Limit 30 lines of text)

项目摘要/摘要： 该提案的主要目的是提供Tanya Johns，MD，MHS，MHS，临床研究者 阿尔伯特·爱因斯坦医学院/蒙特菲奥尔医学学院医学系（肾脏病科） 中心，具有发展为独立临床研究人员所必需的技能和指导 以及全国认可的专家，专注于减少慢性肾脏疾病（CKD）的健康差异。博士 约翰斯的研究建议检查饮食模式与炎症之间的关系及其 种族/族裔少数民族的肾功能下降。越来越多的证据表明 炎症性饮食模式可能会对肾脏健康产生不利影响；但这尚未得到充分调查， 尤其是在少数民族中遭受过多的CKD燃烧。约翰博士将利用大型，良好的 建立的NIH资助了种族/族裔少数民族的同类，并具有纵向数据，以测试饮食的关联 - 诱导的炎症随肾功能下降而诱发。她还将检查多元文化健康的影响 饮食（抗炎饮食模式）对CKD风险的干预以及患者的可行性 已建立的CKD。特别是，她的目标是：1）在社区居住的非洲人中表征饮食模式 美国人（n = 5,306）和西班牙裔（n = 16,415）及其与全身注射和肾脏的关联 功能下降； 2）评估多元文化健康饮食（MHD）干预对CKD风险的影响 较老的种族/族裔少数族裔参与者的临床试验正在进行中（n = 277）； 3）进行小型 试点研究（n = 20），以评估种族/族裔的MHD样干预的可行性和可接受性 少数民族有CKD。为了成功完成这些研究的目的并过渡到独立性，约翰斯博士 已经制定了一项全面的3年研究计划，其中包括：i）来自多学科的概念化 具有营养专业知识的团队，进行队列研究的纵向数据分析，临床试验，比较 有效研究和健康差异研究； ii）完成营养流行病学课程， 生物统计学，比较有效性研究和临床试验； iii）通过她的工作传播 在高影响期刊上的国家研究会议和出版物上的演讲； iv）赠款 旨在在颁奖期结束之前撰写竞争性R01的活动。约翰博士的每个成员 指导团队有成功的心理少年调查员的悠久记录，并且完全致力于 共同努力帮助她实现职业基准并获得研究独立性。资源 在阿尔伯特·爱因斯坦（Albert Einstein）提供了一个理想的环境，以完成她的培训和研究目标。与 从她的研究和职业发展活动中获得的知识和专业知识，约翰斯博士将很好 被毒害评估CKD的新风险因素，这将为开发和实施饮食或 在种族/族裔少数民族中停止肾脏疾病启动和进展的其他干预措施。有了这个奖项， Tanya Johns博士将为担任独立临床研究员的职业做好充分的准备。 （30行；限制30 文字行）