Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

少数族裔的饮食相关炎症和肾功能下降

• 批准号: 10540756
• 负责人: Tanya Johns
• 金额: $ 18.89万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540756
• 关键词: Address; Advisory Committees; Affect; African American; African American population; Albuminuria; Alzheimer' s disease risk; American; Ancillary Study; Anti-Inflammatory Agents; Award; Benchmarking; Biological Markers; Biometry; Chronic; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Communities; Comparative Effectiveness Research; Data; Data Analyses; Development; Diet; Dietary Intervention; Dietary Practices; Disease Progression; Enrollment; Environment; Ethnic Population; European; Experimental Models; Feasibility Studies; Food Preferences; Funding; Goals; Health; Health Disparities Research; Healthy Eating; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Jackson Heart Study; Journals; Kidney; Kidney Diseases; Knowledge; Longitudinal Studies; Measures; Mediating; Medical center; Medicine; Mediterranean Diet; Mentors; Mentorship; Minority Groups; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Oxidative Stress; Participant; Pattern; Pilot Projects; Population Heterogeneity; Prevention; Publications; Race; Randomized, Controlled Trials; Reduce health disparities; Renal function; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk; Risk Factors; TNF gene; Testing; Text; Training; United States National Institutes of Health; Woman; Women' s Health; Work; Writing; acceptability and feasibility; arm; career; career development; clinical trial implementation; cohort; college; comparative effectiveness study; comparison control; cost; design; dietary; dietary approach; disorder risk; endothelial dysfunction; ethnic diversity; ethnic minority; experience; functional decline; health disparity; high risk; improved; indexing; intervention effect; lifestyle factors; low socioeconomic status; meetings; member; mortality; multidisciplinary; novel; nutrition; nutritional epidemiology; programs; racial diversity; racial minority; recruit; renal damage; research and development; skills; systemic inflammatory response; therapeutic target; treatment arm

PROJECT SUMMARY/ ABSTRACT: The primary purpose of this proposal is to provide Tanya Johns, MD, MHS, a clinical investigator in the Department of Medicine (Division of Nephrology) at Albert Einstein College of Medicine/ Montefiore Medical Center, with the skills and mentored guidance necessary to develop into an independent clinical researcher and a nationally recognized expert focused on reducing health disparities in chronic kidney disease (CKD). Dr. Johns’ research proposal examines the relationship between dietary patterns and inflammation, and its association with kidney function decline in racial/ethnic minorities. Growing evidence suggests that pro- inflammatory dietary patterns may adversely impact kidney health; but this has not been fully investigated, especially in minority populations who bear an excess burden of CKD. Dr. Johns will leverage large, well- established NIH funded cohorts of racial/ethnic minorities with longitudinal data to test the association of diet- induced inflammation with kidney function decline. She will also examine the effects of the Multicultural Healthy Diet (anti-inflammatory dietary pattern) intervention on CKD risk, and the feasibility in individuals with established CKD. Specifically, she aims to: 1) characterize dietary patterns in community-dwelling African Americans (n= 5,306) and Hispanics (n= 16,415) and its associations with systemic inflammation and kidney function decline; 2) evaluate the effect of the Multicultural Healthy Dietary (MHD) intervention on CKD risk in an ongoing clinical trial of older predominately racial/ethnic minority participants (n= 277); and 3) conduct a small pilot study (n= 20) to evaluate the feasibility and acceptability of a MHD-like intervention in racial/ethnic minorities with CKD. To successfully complete these research aims and transition to independence, Dr. Johns has developed a comprehensive 3-year research program that includes: i) mentorship from a multidisciplinary team with expertise in nutrition, longitudinal data analyses for cohort studies, clinical trials, comparative effectiveness studies, and health disparities research; ii) completion of courses in nutritional epidemiology, biostatistics, comparative effectiveness research, and clinical trials; iii) dissemination of her work through presentations at national research meetings and publications in high impact journals; iv) grantsmanship activities geared towards writing a competitive R01 by the end of her award period. Each member of Dr. Johns’ mentorship team has a long track record of successfully mentoring junior investigators, and is fully committed to working together to help her achieve career benchmarks and attain research independence. The resources at Albert Einstein provides an ideal environment in which to complete her training and research goals. With the knowledge and expertise gained from her research and career development activities, Dr. Johns will be well poised to evaluate novel risk factors for CKD, which will inform the development and implementation dietary or other interventions to halt kidney disease initiation and progression in racial/ ethnic minorities. With this award, Dr. Tanya Johns will be well prepared for a career as an independent clinical investigator. (30 lines; Limit 30 lines of text)

项目总结/摘要： 本提案的主要目的是提供Tanya Johns，MD，MHS，临床研究者， 阿尔伯特·爱因斯坦医学院医学系（肾脏科）/ Montefiore Medical 中心，具有发展成为独立临床研究人员所需的技能和指导 和一位全国公认的专家，专注于减少慢性肾脏疾病（CKD）的健康差异。博士 约翰斯的研究计划调查了饮食模式和炎症之间的关系， 与种族/少数民族肾功能下降相关。越来越多的证据表明，亲- 炎症性饮食模式可能对肾脏健康产生不利影响;但这尚未得到充分研究， 特别是在患有CKD的过度负担的少数人群中。约翰斯博士会利用大量的，嗯- 建立了NIH资助的种族/少数民族队列，并提供纵向数据，以测试饮食- 诱发炎症伴肾功能下降。她还将研究多元文化健康的影响， 饮食（抗炎饮食模式）干预对CKD风险的影响，以及在患有CKD的个体中的可行性 建立CKD。具体来说，她的目标是：1）描述社区居住的非洲人的饮食模式， 美国人（n= 5，306）和西班牙人（n= 16，415）及其与全身性炎症和肾脏疾病的相关性 功能下降; 2）评估多文化健康饮食（MHD）干预对CKD风险的影响， 正在进行的老年主要种族/少数民族参与者的临床试验（n= 277）;和3）进行一项小型 初步研究（n= 20），以评估MHD样干预在种族/民族中的可行性和可接受性 少数CKD患者。为了成功完成这些研究目标并过渡到独立，Johns博士 已经制定了一个全面的3年研究计划，其中包括：i）从多学科的导师 具有营养学、队列研究纵向数据分析、临床试验、比较 有效性研究和健康差异研究;二）完成营养流行病学课程， 生物统计学，比较有效性研究和临床试验; iii）通过 在国家研究会议上发言并在影响力大的期刊上发表文章;四） 在她的奖励期结束时，她将参加旨在撰写具有竞争力的R 01的活动。约翰博士的每一位成员 导师团队拥有成功指导初级调查员的长期记录，并全力以赴 共同努力，帮助她实现职业基准，并获得研究独立。的资源 在阿尔伯特爱因斯坦提供了一个理想的环境，以完成她的培训和研究目标。与 从她的研究和职业发展活动中获得的知识和专业知识，约翰斯博士将很好地 准备评估CKD的新风险因素，这将为制定和实施饮食或 其他干预措施，以阻止种族/少数民族的肾脏疾病发生和进展。有了这个奖， 博士Tanya Johns将为独立临床研究者的职业生涯做好充分准备。(30线;限制30 文本行）