Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

少数族裔的饮食相关炎症和肾功能下降

• 批准号: 10540756
• 负责人: Tanya Johns
• 金额: $ 18.89万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540756
• 关键词: Address; Advisory Committees; Affect; African American; African American population; Albuminuria; Alzheimer' s disease risk; American; Ancillary Study; Anti-Inflammatory Agents; Award; Benchmarking; Biological Markers; Biometry; Chronic; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Communities; Comparative Effectiveness Research; Data; Data Analyses; Development; Diet; Dietary Intervention; Dietary Practices; Disease Progression; Enrollment; Environment; Ethnic Population; European; Experimental Models; Feasibility Studies; Food Preferences; Funding; Goals; Health; Health Disparities Research; Healthy Eating; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Jackson Heart Study; Journals; Kidney; Kidney Diseases; Knowledge; Longitudinal Studies; Measures; Mediating; Medical center; Medicine; Mediterranean Diet; Mentors; Mentorship; Minority Groups; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Oxidative Stress; Participant; Pattern; Pilot Projects; Population Heterogeneity; Prevention; Publications; Race; Randomized, Controlled Trials; Reduce health disparities; Renal function; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk; Risk Factors; TNF gene; Testing; Text; Training; United States National Institutes of Health; Woman; Women' s Health; Work; Writing; acceptability and feasibility; arm; career; career development; clinical trial implementation; cohort; college; comparative effectiveness study; comparison control; cost; design; dietary; dietary approach; disorder risk; endothelial dysfunction; ethnic diversity; ethnic minority; experience; functional decline; health disparity; high risk; improved; indexing; intervention effect; lifestyle factors; low socioeconomic status; meetings; member; mortality; multidisciplinary; novel; nutrition; nutritional epidemiology; programs; racial diversity; racial minority; recruit; renal damage; research and development; skills; systemic inflammatory response; therapeutic target; treatment arm

PROJECT SUMMARY/ ABSTRACT: The primary purpose of this proposal is to provide Tanya Johns, MD, MHS, a clinical investigator in the Department of Medicine (Division of Nephrology) at Albert Einstein College of Medicine/ Montefiore Medical Center, with the skills and mentored guidance necessary to develop into an independent clinical researcher and a nationally recognized expert focused on reducing health disparities in chronic kidney disease (CKD). Dr. Johns’ research proposal examines the relationship between dietary patterns and inflammation, and its association with kidney function decline in racial/ethnic minorities. Growing evidence suggests that pro- inflammatory dietary patterns may adversely impact kidney health; but this has not been fully investigated, especially in minority populations who bear an excess burden of CKD. Dr. Johns will leverage large, well- established NIH funded cohorts of racial/ethnic minorities with longitudinal data to test the association of diet- induced inflammation with kidney function decline. She will also examine the effects of the Multicultural Healthy Diet (anti-inflammatory dietary pattern) intervention on CKD risk, and the feasibility in individuals with established CKD. Specifically, she aims to: 1) characterize dietary patterns in community-dwelling African Americans (n= 5,306) and Hispanics (n= 16,415) and its associations with systemic inflammation and kidney function decline; 2) evaluate the effect of the Multicultural Healthy Dietary (MHD) intervention on CKD risk in an ongoing clinical trial of older predominately racial/ethnic minority participants (n= 277); and 3) conduct a small pilot study (n= 20) to evaluate the feasibility and acceptability of a MHD-like intervention in racial/ethnic minorities with CKD. To successfully complete these research aims and transition to independence, Dr. Johns has developed a comprehensive 3-year research program that includes: i) mentorship from a multidisciplinary team with expertise in nutrition, longitudinal data analyses for cohort studies, clinical trials, comparative effectiveness studies, and health disparities research; ii) completion of courses in nutritional epidemiology, biostatistics, comparative effectiveness research, and clinical trials; iii) dissemination of her work through presentations at national research meetings and publications in high impact journals; iv) grantsmanship activities geared towards writing a competitive R01 by the end of her award period. Each member of Dr. Johns’ mentorship team has a long track record of successfully mentoring junior investigators, and is fully committed to working together to help her achieve career benchmarks and attain research independence. The resources at Albert Einstein provides an ideal environment in which to complete her training and research goals. With the knowledge and expertise gained from her research and career development activities, Dr. Johns will be well poised to evaluate novel risk factors for CKD, which will inform the development and implementation dietary or other interventions to halt kidney disease initiation and progression in racial/ ethnic minorities. With this award, Dr. Tanya Johns will be well prepared for a career as an independent clinical investigator. (30 lines; Limit 30 lines of text)

项目摘要/摘要： 这项建议的主要目的是为Tanya Johns，医学博士，MHS，一名临床研究员提供 阿尔伯特·爱因斯坦医学院/蒙特菲奥里医学院肾脏病学系 中心，拥有发展成为独立临床研究人员所需的技能和指导 以及一位全国公认的专家，专注于减少慢性肾脏疾病(CKD)的健康差距。Dr。 约翰斯的研究提案考察了饮食模式和炎症之间的关系，以及它的 少数族裔与肾功能下降的关系。越来越多的证据表明，支持- 炎症性饮食模式可能会对肾脏健康造成不利影响；但这一点尚未得到充分调查， 特别是在少数群体中，他们承受着CKD的过多负担。约翰斯博士将利用巨大的，好的- 美国国立卫生研究院资助了种族/少数民族队列，并提供了纵向数据，以测试饮食与 诱导炎症反应，肾功能下降。她还将研究多元文化健康的影响 饮食(抗炎饮食模式)对CKD风险的干预，以及在患有CKD的个体中的可行性 建立了CKD。具体地说，她的目标是：1)描述非洲社区居民的饮食模式 美国人(n=5,306)和西班牙人(n=16,415)及其与全身炎症和肾脏的相关性 2)评价多元文化健康饮食(MHD)干预对老年人慢性肾脏病风险的影响 正在进行的以种族/少数民族为主的老年参与者的临床试验(n=277)；以及3)进行一项小规模的 评估类似MHD的种族/民族干预的可行性和可接受性的试点研究(n=20) 患有慢性肾脏病的少数民族。为了成功完成这些研究目标并过渡到独立，约翰斯博士 制定了一项为期3年的综合研究计划，其中包括：i)多学科的指导 具有营养、队列研究、临床试验、比较研究的纵向数据分析的专业知识的团队 有效性研究和健康差距研究；2)完成营养流行病学课程， 生物统计学、比较有效性研究和临床试验；iii)通过以下途径传播她的工作 在国家研究会议和影响较大的期刊上发表演讲；四)资质 活动是为了在她的获奖期结束时写出一份有竞争力的R01。约翰斯博士的每个成员 指导团队在成功指导初级调查人员方面有着长期的记录，并完全致力于 共同努力，帮助她实现职业基准，实现研究独立。资源 在阿尔伯特，爱因斯坦为完成她的训练和研究目标提供了一个理想的环境。与 从她的研究和职业发展活动中获得的知识和专业知识，约翰斯博士将会很好 准备评估CKD的新风险因素，这将为制定和实施饮食或 其他干预措施，以阻止肾脏疾病在种族/少数族裔中的启动和发展。有了这个奖项， Tanya Johns博士将为独立临床调查员的职业生涯做好充分准备。(30行；限制30行 文本行)