Complexity, Cooperation and Community in Cancer

拟议中的癌症系统生物学中心，将被称为复杂性中心， 癌症合作与共同体，是系统生物学和癌症生物学的共同努力 加州大学欧文分校(UCI)的社区，由两项校园范围的研究代表 组织、复杂生物系统中心和UCI癌症研究所。这个 中心将解决关于癌症系统的各种基本和根本问题，以及它们为什么 就像他们一样有条理。该中心研究计划的前提是癌细胞 在复杂的环境中繁殖和进化，这些环境被高度选中以实现强大的控制 生长和分化，癌细胞的行为只有在 控制该控件的设计原则的上下文。 如本提案所述，该中心将开展三个协调的、以团队为导向的研究项目 关于背景、合作和社区在癌症发生和发展中的作用。一 该项目将利用来自结肠癌异种移植模型的新观察结果来研究非遗传学 实体肿瘤的异质性，其起源及其与肿瘤生长和治疗反应的相关性。 第二个项目将调查黑色素瘤的细胞起源，试图澄清两者之间的关系 黑色素瘤和良性病变(黑色素细胞痣)之间的关系 事件。这项工作将集中在黑素细胞前体之间的相互作用，在皮肤环境中， 在促进从良性向恶性进展的条件下。第三个项目将重点放在 考虑相互作用的慢性粒细胞白血病(CML)及其治疗模型的改进 在等级谱系、细胞间反馈和动力学之间。这三个项目将合并在一起 数学建模、基因组学和动物模型的实验操作。三个人都会是 由在单细胞水平上研究肿瘤细胞的核心设施提供服务，提供访问最新的 在单细胞基因组、转录组和其他技术方面。该中心还将支持短期、 由教员和受训人员(研究生和 博士后研究员)，以及旨在扩大和丰富 癌症系统生物学社区，在大学内，在更大的科学界，以及 在公众中。最后，该中心将协调其研究和外展活动。 NCI癌症系统生物学网络中的其他中心。

The proposed Center for Cancer Systems Biology, to be known as the Center for Complexity, Cooperation and Community in Cancer, is a joint effort by the systems biology and cancer biology communities at the University of California Irvine (UCI), as represented by two campus-wide research organizations, the Center for Complex Biological Systems and the UCI Cancer Research Institute. The center will tackle a variety of basic and fundamental questions about cancer systems, and why they are organized as they are. The premise underlying the research program of the center is that cancer cells proliferate and evolve in complex environments that have been highly selected for the robust control of growth and differentiation, and that the behaviors of cancer cells can only be fully understood in the context of the design principles that govern that control. As described in this proposal, the center will carry out three coordinated, team-oriented research projects on the role of context, cooperation and community in the initiation and progression of cancer. One project will leverage new observations from xenograft models of colon cancer to investigate non-genetic heterogeneity in solid tumors, both its origins and its relevance to tumor growth and response to therapy. A second project will investigate the cellular origins of melanoma, seeking to clarify the relationship between melanoma and the benign lesions (melanocytic nevi) that are driven by a common oncogenic event. This work will focus on interactions among melanocyte precursors, within the skin environment, and under conditions that promote progression from benign to malignant. The third project will focus on improving models of chronic myeloid leukemia (CML) and its treatment, taking into account interactions between hierarchical lineages, intercellular feedback, and dynamics. All three projects will combine mathematical modeling, genomics, and experimental manipulation of animal models. All three will be served by a core facility for investigating tumor cells at the single cell level, providing access to the latest in single-cell genomic, transcriptomic and other technologies. The center will also support short-term, interdisciplinary pilot projects initiated both by faculty and by trainees (graduate students and postdoctoral fellows), as well as a wide variety of outreach activities aimed at expanding and enriching the cancer systems biology community both within the university, in the larger scientific community, and among the public. Finally, the center will coordinate its research and outreach activities with those of other centers in the NCI Cancer Systems Biology network.