Systems Biology Core

系统生物学指的是将数学中的思想和方法整合到生物学中， 工程学、计算机科学、物理学和化学，目的是从 数据--尤其是复杂、动态和/或高维的数据。系统生物学使人们经常 使用显式的、定量的模型，并关注如何从数据中得出有用的模型 以及如何使用模型来生成假设和推动新数据的收集。 现代生物学和生物医学研究正变得越来越依赖系统生物学方法， 然而，因为实施这些方法所需的技能和洞察力来自如此多不同的 对于研究人员来说，充分利用这些学科可能是一件具有挑战性的事情。系统的目标 生物学的核心是使皮肤生物学研究人员能够将系统生物学融入他们的研究中，从而 提高工作效率，提高研究影响力。该核心将帮助皮肤生物学家衍生出更多 从数据中建立有意义的模型；构建和分析明确的、定量的模型；使用模型来解释、分析 并集成数据(包括由其他内核生成的数据)；使用模型生成可测试性并确定其优先顺序 关于功能的假设；更好地理解和利用借鉴系统生物学思想的文献 和接近。通过系统生物学核心提供的方法特别好 适合于基于来自成像和成像的努力的数据并向其中提供输入 基因组学/生物信息学核心。 实现这些目标的战略包括为皮肤生物学家举办有针对性的讲习班，将皮肤纳入 生物学家在一年一度的系统生物学静修，系统生物学“诊所”，在皮肤生物学家识别 需要注意的问题，以及个性化的咨询。这些战略利用专业知识和 在建模和数据分析方面有专长的三个系统生物学学院的资源；长期存在 有教授跨学科科学的经验；以及与皮肤生物学家合作的记录。它还 利用大型校园范围内致力于系统生物学的中心的基础设施，复杂中心 生物系统。

Systems Biology refers to the integration into biology of ideas and methodologies from mathematics, engineering, computer science, physics, and chemistry, with the goal of deriving greater understanding from data—especially data that are complex, dynamic and/or high-dimensional. Systems biology makes frequent use of explicit, quantitative models, and concerns itself both with how useful models can be derived from data as well as how models can be used to generate hypotheses and drive the collection of new data. Modern biological and biomedical research are becoming increasing reliant on systems biology approaches, yet because the skills and insights necessary to implement such approaches come from so many different disciplines, it can be challenging for researchers to take full advantage of them. The goal of the Systems Biology Core is to enable skin biology researchers to incorporate systems biology in their research, thereby enhancing productivity and increasing research impact. The core will help skin biologists derive more meaningful models from data; build and analyze explicit, quantitative models; use models to interpret, analyze, and integrate data (including data generated by other cores); use models to generate and prioritize testable hypotheses about function; and better understand and utilize literature that draws upon systems biology ideas and approaches. Methodologies to be made available through the Systems Biology Core are especially well suited to building upon data from, and providing input into, the efforts of the imaging and genomics/bioinformatics cores. Strategies for achieving these goals include targeted workshops for skin biologists, inclusion of skin biologists in an annual systems biology retreat, systems biology “clinics” at which skin biologists identify problems in need of attention, and individualized consultation. These strategies leverage the expertise and resources of three systems biology faculty with expertise in modeling and data analysis; long-standing experience in teaching interdisciplinary science; and a track-record of collaboration with skin biologists. It also leverages the infrastructure of a large campus-wide center devoted to systems biology, the Center for Complex Biological Systems.