Mathematical, Computational and Systems Biology

计划摘要/摘要 近年来，对生物医学研究人员和临床医生提出了新的要求。 由于我们获取、分析和交互数据的方式发生了变化。许多领域 生物医学正在从数据贫乏和假说丰富过渡到极端 数据丰富，而(相对)假设不足。在这一新的领域进行严格的研究 环境可能是具有挑战性的，因为它不仅需要扎根于生物学，而且还需要扎根于 数学、计算和统计。此应用程序请求支持博士后 旨在培养具有足够基础生物学技能的博士的培训计划， 数学和计算建模，以及应对这些挑战的数据科学 在……上面。该项目建立在一个独立的、跨学科的博士项目的基础上，该项目已经 在过去的十几年里得到了发展和完善，并在 生物科学和数学、计算机科学、物理和工程学。八个Pre- 博士生见习职位申请，每个职位为期两年。 拟议计划的亮点包括广泛的教学课程；重点放在关键 思维能力；强调协作和协作学习；密切指导， 发展多种职业技能的机会；以及学生的积极参与。三一计划 教职员工来自加州大学五个学院的14个不同部门 并在生物学和医学领域进行不同主题的研究。这个 该计划享有强大的校园支持，并在 UCI复杂生物系统中心，国家系统生物学中心，具有长期的 长期致力于促进所有学术水平的跨学科教育。这个 拟议的计划将为受训人员在生物医学研究、教学和 学术和非学术环境中的交流。

Program Summary/Abstract In recent years, new demands are being placed on biomedical researchers and clinicians thanks to changes in the way we acquire, analyze and interact with data. Many areas of biomedical science are transitioning from being data-poor and hypothesis-rich to extremely data-rich and (comparatively) hypothesis-poor. Conducting rigorous research in this new environment can be challenging, as it requires grounding not just in biology, but also in mathematics, computation and statistics. This application requests support for a pre-doctoral training program designed to produce Ph.D.s with sufficient skills in fundamental biology, mathematical and computational modeling, and data science to attack these challenges head on. The program is built upon a free-standing, interdisciplinary Ph.D. program that has been developed and refined over the past dozen years, and offers training at the interface between the biological sciences and mathematics, computer science, physics and engineering. Eight pre- doctoral trainee slots are requested, for appointments intended to last two years each. Highlights of the proposed program include an extensive didactic curriculum; a focus on critical thinking skills; an emphasis on collaboration and collaborative learning; close mentoring, opportunities to develop multiple career skills; and active student involvement. The 31 program faculty members come from 14 different departments in five schools at the University of California, Irvine, and conduct research on diverse topics within biology and medicine. The program enjoys strong campus support, and an administrative and intellectual home within the UCI Center for Complex Biological Systems, a National Center for Systems Biology with a long- standing commitment to promoting interdisciplinary education at all academic levels. The proposed program will prepare trainees for careers in biomedical research, teaching, and communication in both academic and non-academic settings.