Biobehavioral self-regulatory processes underlying real-time binge eating symptoms and obesity risk

摘要 这份以患者为导向的导师研究职业发展奖的申请书提出了培训和 旨在为应聘者提供建立成功职业生涯的基础的研究 独立调查员，在情感、神经认知和神经学机制方面具有专业知识 饮食精神病和肥胖症。候选人寻求在三个领域进行高级培训，每个领域 以她先前的知识和经验为基础，进行生态瞬时评估(EMA)和情感 饮食失调和肥胖：(1)饮食行为和肥胖的神经生物学机制， 包括功能磁共振成像(FMRI)方法；(2)自我控制的神经科学 与进食的关系；(3)多方法动态评估与干预的设计与分析 接近了。培训将由一个跨学科团队(导师和合作者)指导，并将包括 正式活动(如课程作业、研讨会)和非正式活动(如定向阅读、辅导会议) 在整个资助期内。研究计划利用了这些培训经验，并提出了多项 检查生物行为自我调节过程如何预测瞬间暴饮暴食和 短期体重变化。具体地说，这项研究将考察对食物的影响和注意力偏向的程度 线索和冲动(通过EMA、行为任务和功能磁共振成像测量)相互作用，预测实时暴饮暴食 75名有肥胖风险的成年人(即有肥胖风险的人)的症状和随后的体重变化 支持经常暴饮暴食的超重体重指数)。参与者将完成面试、自我评估 报告措施，一种包括反应抑制和延迟折扣任务的功能磁共振成像协议，为期两周 EMA方案，包括基于动态任务的注意力偏向测量，以及为期6个月的随访 评估体重变化的评估。重要的是，这项研究的结果将确定生物行为 暴饮暴食和肥胖风险的潜在机制，这将有助于了解新的预防和 干预措施。综上所述，这项拟议的研究将促进对暴饮暴食的理解 在肥胖背景下的精神病理学，并将为候选人未来的研究计划奠定基础。 该奖项提供的培训和指导将进一步促进候选人成功地成为 一名独立调查员，具有多方法流动战略方面的专门知识，以查明和 针对导致进食和体重失调的机制。

Abstract This application for a Mentored Patient-Oriented Research Career Development Award proposes training and research designed to provide the candidate with a foundation to establish a successful career as an independent investigator with expertise in affective, neurocognitive, and neurological mechanisms underlying eating psychopathology and obesity. The candidate seeks advanced training in three areas, each of which build upon her prior knowledge and experience with ecological momentary assessment (EMA) and emotion dysregulation in eating disorders and obesity: (1) neurobiological mechanisms of eating behavior and obesity, including functional magnetic resonance imaging (fMRI) methodology; (2) neuroscience of self-control in relation to eating; and (3) design and analysis of multi-method ambulatory assessment and intervention approaches. Training will be guided by an interdisciplinary team (mentors and collaborators) and will involve formal (e.g., coursework, workshops) and informal (e.g., directed readings, mentoring meetings) activities across the funding period. The research plan harnesses these training experiences and proposes a multi- method study to examine how biobehavioral self-regulatory processes predict momentary binge eating and short-term weight change. Specifically, this study will examine the extent to which affect, attention bias to food cues, and impulsivity (measured via EMA, behavioral tasks, and fMRI) interact to predict real-time binge eating symptoms and subsequent weight change among a sample of 75 adults at risk for obesity (i.e., those with overweight body mass index who endorse regular binge eating). Participants will complete interviews, self- report measures, an fMRI protocol that includes response inhibition and delay discounting tasks, a two-week EMA protocol that includes ambulatory task-based measurement of attention bias, and a six-month follow-up assessment to assess weight change. Importantly, results of this research will identify biobehavioral mechanisms underlying binge eating and obesity risk, which will help to inform novel prevention and interventions. Taken together, the proposed study will advance the understanding of binge eating psychopathology in the context of obesity, and will set the stage for the candidate's future program of research. The training and mentorship provided by the award will further facilitate the candidate's success in becoming an independent investigator, with particular expertise in multi-method ambulatory strategies to identify and target mechanisms contributing to eating and weight disorders.