Microbiomics and Functional Genomics Core
微生物组学和功能基因组学核心
基本信息
- 批准号:10395973
- 负责人:
- 金额:$ 26.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:ATAC-seqBase PairingBasic ScienceBioinformaticsBiological AssayCaliforniaCellsChIP-seqComplexComputational BiologyConsultConsultationsDataData AnalysesData SetDigestive System DisordersEnsureEnvironmental Risk FactorGene ExpressionGenetic PolymorphismGenomic medicineGenomicsGlassHigh-Throughput Nucleotide SequencingHuman ResourcesInflammatory Bowel DiseasesInfrastructureInstitutesInternationalLibrariesLiverLocationMedicineMetagenomicsMolecular GeneticsPathogenesisPreparationProceduresProcessProtocols documentationQuality ControlResearchResearch DesignResearch PersonnelResource SharingResourcesRibosomal RNASamplingServicesShotgun SequencingSignal PathwayStandardizationStatistical Data InterpretationSusceptibility GeneSystemTechniquesTechnologyTrainingTranslational ResearchUniversitiesValidationbasecostcost effectivedata visualizationdesignexome sequencingexperiencefunctional genomicsgenome sequencinggenomic dataglobal run on sequencinginnovationmembermiRNA expression profilingmicrobialmicrobial communitymicrobiomemicrobiome researchnext generation sequencingnon-alcoholic fatty liver diseaseresponseribosome profilingtooltranscriptome sequencingtranscriptomicswhole genome
项目摘要
Summary
Complex interactions between numerous specialized host cells in gut, liver and other locations, polymorphisms
of multiple susceptibility genes and their associated signaling pathways and functions, and a myriad of microbial
and other environmental factors are emerging as central to the pathogenesis of many of the most important
digestive diseases, as exemplified by inflammatory bowel disease (IBD) and non-alcoholic fatty liver disease
(NAFLD). It is becomingly increasingly evident that more comprehensive views of the players and interactions
are needed to unravel many of the most perplexing digestive diseases. Consequently, tools to characterize and
define multiple host and microbial cells and their gene expression responses are increasingly important and
essential for digestive diseases research. Most advanced among these tools are technologies based on high-
throughput sequencing, as it is now routinely possible to obtain hundreds of millions of base pairs of sequence
at modest costs. Next-generation sequencing technologies have revolutionized basic and translational research
in medicine over the last several years, and are in increasing demand in digestive diseases research.
Consequently, we have designed the Microbiomics and Functional Genomics Core to provide advanced
microbiomics and genomics services to Center members, and offer consultation and training in genomics
technologies to enhance the ability of members to implement these technologies in their research. Specifically,
the Core will: 1) Conduct sequencing-based assays for microbiomics and functional genomics; 2) Perform
bioinformatics analyses of sequencing-based assays; 3) Consult and advise in studies involving microbiomics
and functional genomics; and 4) Provide validated experimental protocols and training. The Core leverages
several established institutional shared resources, including the Center for Microbiome Innovation at the
University of California, San Diego (UCSD), the Genomics Center of the Institute for Genomic Medicine at UCSD,
and the UCSD Center for Computational Biology and Bioinformatics. This unique combination and integration of
outstanding existing resources will ensure that Center members have access to cutting-edge technologies for
studies involving microbiomics and functional genomics. The Core will be directed by internationally recognized
experts in microbiomics (Dr. Rob Knight) and functional genomics (Dr. Christopher Glass), and other Core
personnel are highly experienced in microbiome science, molecular genetics, bioinformatics and computational
biology. The Core has established rigorous procedures for quality control and data validation. Together, this
infrastructure and expertise will enable the Microbiomics and Functional Genomics Core to provide a range of
high quality and cost-effective microbiomics and functional genomics services that greatly enhance the ability of
Center members to advance digestive diseases research.
摘要
肠道、肝脏和其他位置的许多专门化宿主细胞之间的复杂相互作用,多态
多种易感基因及其相关的信号通路和功能,以及无数的微生物
而其他环境因素正在成为许多最重要的
消化系统疾病,如炎症性肠病(IBD)和非酒精性脂肪肝
(NAFLD)。越来越明显的是,对球员和互动的更全面的看法
是解开许多最令人困惑的消化系统疾病所必需的。因此,用来表征和分析
定义多个宿主和微生物细胞及其基因表达反应日益重要
对消化系统疾病的研究至关重要。这些工具中最先进的是基于高科技的技术
吞吐量测序,因为现在可以常规地获得数亿个碱基对的序列
花费不多。下一代测序技术已经彻底改变了基础研究和翻译研究
在过去的几年里,在医学上,对消化系统疾病的研究有越来越多的需求。
因此,我们设计了微生物和功能基因组核心,以提供先进的
为中心成员提供微生物学和基因组学服务,并提供基因组学咨询和培训
提高成员在其研究中实施这些技术的能力。具体来说,
核心将:1)进行基于测序的微生物和功能基因组学分析;2)执行
基于测序分析的生物信息学分析;3)在涉及微生物学的研究中提供咨询和建议
和功能基因组学;以及4)提供经过验证的实验方案和培训。核心利用
几个已建立的机构共享资源,包括位于
加州大学圣地亚哥分校(UCSD),加州大学圣地亚哥分校基因组医学研究所基因组学中心,
以及加州大学圣地亚哥分校计算生物学和生物信息学中心。这种独特的组合和集成
出色的现有资源将确保中心成员能够获得尖端技术
涉及微生物学和功能基因组学的研究。《核心》将由国际公认的导演
微生物学(Rob Knight博士)和功能基因组学(Christopher Glass博士)以及其他核心领域的专家
人员在微生物组科学、分子遗传学、生物信息学和计算机方面经验丰富。
生物学。核心建立了严格的质量控制程序和数据验证程序。总而言之,这
基础设施和专业知识将使微生物和功能基因组学核心能够提供一系列
高质量、高性价比的微生物和功能基因组学服务,大大增强了
中心成员推进消化系统疾病研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROB KNIGHT其他文献
ROB KNIGHT的其他文献
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{{ truncateString('ROB KNIGHT', 18)}}的其他基金
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10226176 - 财政年份:2019
- 资助金额:
$ 26.38万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10015205 - 财政年份:2019
- 资助金额:
$ 26.38万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10450189 - 财政年份:2019
- 资助金额:
$ 26.38万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10681220 - 财政年份:2019
- 资助金额:
$ 26.38万 - 项目类别:
Data Infrastructure and Molecular Atlas for Alzheimer's Disease: Connecting Exposome, Gut Microbiome, and Metabolome.
阿尔茨海默病的数据基础设施和分子图谱:连接暴露组、肠道微生物组和代谢组。
- 批准号:
10659795 - 财政年份:2019
- 资助金额:
$ 26.38万 - 项目类别:
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites
HIV CVD风险的综合分析:肠道菌群、免疫功能和代谢物
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9476675 - 财政年份:2018
- 资助金额:
$ 26.38万 - 项目类别:
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