Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
基本信息
- 批准号:10681220
- 负责人:
- 金额:$ 110.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-30 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAmericanAntimicrobial ResistanceBackBiocompatible MaterialsBiological AssayBiological MarkersChemicalsCommunicable DiseasesConsumptionDNA sequencingDataData SetDietDietary ComponentDisease ResistanceEnhancersGene ExpressionHumanImmune systemImmunityIndividualInfrastructureLaboratory StudyLiquid substanceMapsMass Spectrum AnalysisMetabolite InteractionMicrobeMineralsMiniaturizationNational Health and Nutrition Examination SurveyNutritional statusPharmaceutical PreparationsPhytochemicalPopulationProcessResearch PersonnelResistanceRobotSamplingSupplementationSystemTestingUnited StatesVisualVitaminsWorkburden of illnesscohortcostdata integrationdeep learningdietaryhuman subjectimmunological statusimprovedinsightmetabolomemicrobiomemouse modelnanolitre scalepreventpublic health relevanceside effecttranscriptome sequencing
项目摘要
Project Summary
Antimicrobial resistance is an increasing problem, and current drug pipelines are not keeping pace with the rise
of antimicrobial resistance. An alternative strategy is to boost host immunity. An often overlooked side-effect of
the vitamin and mineral supplementation projects of the 1940s is that these supplements greatly reduced
infectious disease burden. Recent work has shown that further gains may be possible, especially in adding
phytochemicals back to highly processed diets typically consumed in the United States. However, we lack a
fundamental understanding of how these components are processed by the microbiome, and how diet-derived
molecules, microbiome and host immune system work together to resist infectious disease.
A key barrier preventing us from making these discoveries is that each individual assay (microbiome, host
gene expression metabolome, dietary compounds) is expensive and highly multivariate. Three key insights that
enable the current project are the miniaturization of DNA and RNA sequencing assays on advanced nanoliter-
scale liquid handling robots, greatly reducing the cost, the combination of untargeted and targeted mass
spectrometry on the same samples in high throughput to enable discovery of a much greater chemical space,
and the ability to use explicitly spatial maps on multiple scales to integrate the dataset throughout the body and
enable both visual analytics and deep learning approaches based on spatial data. These breakthroughs will
provide a fundamentally new understanding of how dietary metabolites promote disease resistance, and will
allow us to develop a new infrastructure to integrate results from many investigators in different laboratories
studying various aspects of these systems. Additionally, the results will allow us to choose biomaterials and
biomarkers in human subjects that provide maximum information about internal nutritional and immune status.
Results will be tested against the NHANES and American Gut cohorts.
The results of this project will therefore be: 3D maps of mouse models showing how the microbiome, diet, and
host gene expression produce immunity; an infrastructure for creating and sharing these maps; and a
preliminary test of whether the results extend to large human populations.
项目总结
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding.
- DOI:10.1016/j.medj.2021.05.003
- 发表时间:2021-08-13
- 期刊:
- 影响因子:0
- 作者:Song SJ;Wang J;Martino C;Jiang L;Thompson WK;Shenhav L;McDonald D;Marotz C;Harris PR;Hernandez CD;Henderson N;Ackley E;Nardella D;Gillihan C;Montacuti V;Schweizer W;Jay M;Combellick J;Sun H;Garcia-Mantrana I;Gil Raga F;Collado MC;Rivera-Viñas JI;Campos-Rivera M;Ruiz-Calderon JF;Knight R;Dominguez-Bello MG
- 通讯作者:Dominguez-Bello MG
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ROB KNIGHT其他文献
ROB KNIGHT的其他文献
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{{ truncateString('ROB KNIGHT', 18)}}的其他基金
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10226176 - 财政年份:2019
- 资助金额:
$ 110.6万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10015205 - 财政年份:2019
- 资助金额:
$ 110.6万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10450189 - 财政年份:2019
- 资助金额:
$ 110.6万 - 项目类别:
Data Infrastructure and Molecular Atlas for Alzheimer's Disease: Connecting Exposome, Gut Microbiome, and Metabolome.
阿尔茨海默病的数据基础设施和分子图谱:连接暴露组、肠道微生物组和代谢组。
- 批准号:
10659795 - 财政年份:2019
- 资助金额:
$ 110.6万 - 项目类别:
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites
HIV CVD风险的综合分析:肠道菌群、免疫功能和代谢物
- 批准号:
9476675 - 财政年份:2018
- 资助金额:
$ 110.6万 - 项目类别:
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