Alzheimer's Gut Microbiome Project
阿尔茨海默氏症肠道微生物组项目
基本信息
- 批准号:10017837
- 负责人:
- 金额:$ 542.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3xTg-AD mouseAffectAlzheimer disease preventionAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease patientAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerAmericanAminesAnimal ModelBacteriaBehavior DisordersBile AcidsBiochemicalBiological ModelsBloodBrainBrain imagingCellsCentral Nervous System DiseasesChemicalsClinicalCognitionCognition DisordersCognitiveCommunicationCommunitiesComputational BiologyControlled Clinical TrialsDataData AnalysesData SetDementiaDepressed moodDevelopmentDietDiseaseDisease ProgressionEmotional disorderEnvironmental ExposureEtiologyFAIR principlesFailureFoodGenerationsGeneticGoalsHealthHeterogeneityHumanHuman MicrobiomeImageImmune systemImmunologicsInformaticsInfrastructureInterventionKnowledgeLeadLife StyleLinkLipidsManipulative TherapiesMediatingMental DepressionMental disordersMetabolicMetabolismMetagenomicsMethodologyMicrobeMultiple SclerosisMusNervous system structureNeurobehavioral ManifestationsNeurodegenerative DisordersNeurotransmittersParkinson DiseasePathogenesisPathologyPatientsPeripheralPersonsPharmacologyPhenotypePlayPre-Clinical ModelProcessResearchResourcesRoleSchizophreniaSymptomsSystems BiologyTechnologyTranslationsViralVolatile Fatty AcidsWorkXenobioticsautism spectrum disorderbasebiobankcohortcytotoxicdeep learningdisease heterogeneitydisease phenotypedrug developmentendophenotypefecal metabolomegut bacteriagut microbiomegut-brain axisimprovedinsightmetabolomemetabolomicsmicrobiomemicrobiome alterationmicrobiome compositionmicrobiome researchmultidisciplinarynervous system disorderneuropsychiatric disorderneuropsychiatric symptomnew therapeutic targetnovel markernovel strategiesnovel therapeuticsopen dataoutcome forecastphenotypic biomarkerpre-clinicalprecision medicinepreventprogramspublic health relevancerepositoryresponsesocioeconomicssymposium
项目摘要
ABSTRACT – Overall
Behavioral, emotional and cognitive disorders have been historically studied as diseases of the central nervous
system (CNS). However, emerging data suggests a gut-brain connection in a variety of diseases that affect the
brain. Our own data and others’ suggests a gut-brain connection in Alzheimer’s disease (AD), a progressive
neurodegenerative disorder that is the leading cause of dementia. There are currently no therapies to prevent
or slow AD progression, causing a huge socioeconomic burden and highlighting our incomplete knowledge.
Given an emerging role for gut microbiome and hypotheses implicating viral and bacterial contributions to AD
pathogenesis, defining the bidirectional biochemical communication between the brain and the gut will improve
understanding of neurodegenerative and psychiatric diseases. Indeed, it is crucial to study the brain not in
isolation, but in the context of peripheral influences including diet, lifestyle, and microbiome. In this proposal we
build on large initiatives and infrastructures co-established by our multi-disciplinary team including: The
American Gut Project, The AD Metabolomics Consortium, Alzheimer’s Disease Research Centers (ADRCs),
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), The National
Alzheimer’s Coordinating Center (NACC) and centers of excellence in informatics and systems biology. We
aim to define the role of gut microbiome in AD pathogenesis and biochemical axis of communication between
gut and brain. Aim 1: Examine the association between the gut microbiome and AD phenotypes. Aim 2:
Define the biochemical axis of communication between the gut microbiome and the brain and identify
metabolites that contribute to AD endophenotypes. Aim 3: Examine mechanistic links between the
activity of the gut microbiome and AD pathogenesis, and identify new approaches for AD prevention
that target the gut-brain axis. These aims will be enabled three projects supported by an Omics and
Technology Core, a Computational and Systems Biology Core, and an Administrative Core that provides data
and biorepository infrastructure. Project 1 will define changes in gut microbiome and metabolome across the
AD trajectory; Project 2 leverages three existing clinical trials of controlled diets to examine dietary effects on
gut microbiome, metabolome, cognition and brain imaging; Project 3 examines mechanism by defining gut-
brain communication and microbiome-based interventions in animal models of AD. In this U19 we will create
an unprecedented, high-quality dataset and resources specifically for the AD research community, and make
these available under open science, FAIR (findable, accessible, interoperable, reusable) data principles. With
our cross-disciplinary team of experts in clinical AD, gut microbiome research, imaging, metabolomics,
informatics, deep learning and systems biology, this effort will yield novel biomarkers for AD progression and
prognosis, and insight into mechanisms opening the door to development of transformative options for AD.
摘要-总体
行为、情绪和认知障碍在历史上一直作为中枢神经系统疾病进行研究
系统(CNS)。然而,新出现的数据表明,在各种疾病中,肠-脑的联系会影响大脑的功能。
个脑袋我们自己的数据和其他人的数据表明,阿尔茨海默病(AD)中存在肠-脑联系,
神经退行性疾病是痴呆症的主要原因。目前没有治疗方法可以预防
或缓慢的AD进展,造成巨大的社会经济负担,并突出我们的知识不完整。
鉴于肠道微生物组的新作用以及涉及病毒和细菌对AD的贡献的假设
发病机制,定义大脑和肠道之间的双向生化通讯将改善
了解神经退行性疾病和精神疾病。事实上,研究大脑是至关重要的,
隔离,但在周边影响的背景下,包括饮食,生活方式和微生物。在本提案中,我们
以我们的多学科团队共同建立的大型计划和基础设施为基础,包括:
美国肠道项目,AD代谢组学联盟,阿尔茨海默病研究中心(ADRC),
国家阿尔茨海默病和相关痴呆症中央储存库(NCRAD),国家
阿尔茨海默氏症协调中心(NACC)和信息学和系统生物学卓越中心。我们
目的是确定肠道微生物组在AD发病机制中的作用以及AD与肠道微生物之间的生物化学交流轴。
肠道和大脑。目的1:检查肠道微生物组与AD表型之间的关联。目标二:
定义肠道微生物组和大脑之间的生物化学交流轴,
导致AD内表型的代谢物。目标3:审查
肠道微生物组的活动和AD发病机制,并确定预防AD的新方法
以肠脑轴为目标。这些目标将使三个项目的支持下,一个组学和
技术核心,计算和系统生物学核心,以及提供数据的管理核心
和生物储存库的基础设施。项目1将定义整个研究期间肠道微生物组和代谢组的变化。
AD轨迹;项目2利用现有的三项控制饮食的临床试验来检查饮食对AD的影响。
肠道微生物组、代谢组、认知和大脑成像;项目3通过定义肠道来研究机制
脑通信和基于微生物群的干预AD动物模型。在这个U19中,我们将创建
一个前所未有的,高质量的数据集和资源,专门为AD研究界,并使
这些都是在开放科学、公平(可发现、可访问、可互操作、可重用)数据原则下提供的。与
我们的跨学科专家团队在临床AD,肠道微生物组研究,成像,代谢组学,
信息学、深度学习和系统生物学,这项工作将产生新的AD进展生物标志物,
预后,并深入了解机制,为AD的转型选择的发展打开大门。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROB KNIGHT其他文献
ROB KNIGHT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROB KNIGHT', 18)}}的其他基金
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10226176 - 财政年份:2019
- 资助金额:
$ 542.41万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10015205 - 财政年份:2019
- 资助金额:
$ 542.41万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10450189 - 财政年份:2019
- 资助金额:
$ 542.41万 - 项目类别:
Mapping host-microbe-metabolite interactions in 3D to find diet-derived enhancers of immunity
绘制 3D 宿主-微生物-代谢物相互作用图,寻找饮食来源的免疫增强剂
- 批准号:
10681220 - 财政年份:2019
- 资助金额:
$ 542.41万 - 项目类别:
Data Infrastructure and Molecular Atlas for Alzheimer's Disease: Connecting Exposome, Gut Microbiome, and Metabolome.
阿尔茨海默病的数据基础设施和分子图谱:连接暴露组、肠道微生物组和代谢组。
- 批准号:
10659795 - 财政年份:2019
- 资助金额:
$ 542.41万 - 项目类别:
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites
HIV CVD风险的综合分析:肠道菌群、免疫功能和代谢物
- 批准号:
9476675 - 财政年份:2018
- 资助金额:
$ 542.41万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 542.41万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 542.41万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 542.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 542.41万 - 项目类别:
Studentship